Harbin Engineering University

About: Harbin Engineering University is a education organization based out in Harbin, Heilongjiang, China. It is known for research contribution in the topics: Control theory & Computer science. The organization has 31149 authors who have published 27940 publications receiving 276787 citations. The organization is also known as: HEU.

Multifunctional UCNPs@PDA-ICG nanocomposites for upconversion imaging and combined photothermal/photodynamic therapy with enhanced antitumor efficacy

Abstract: Integrated theranostic nanosystems that combine therapeutic methods with suitable medical imaging modality are highly needed in the improvement of cancer theranostic approaches. Herein, polydopamine (PDA)-shelled NaYF4:Yb,Er@NaYF4:Yb nanoparticles (UCNPs) capable of loading indocyanine green (ICG) molecules via electrostatic adsorption, hydrophobic interaction and π–π stacking were successfully designed and synthesized (UCNPs@PDA-ICG, denoted as UPI) for upconversion imaging and combined photothermal/photodynamic therapy (PTT/PDT) with enhanced antitumor efficacy. We have found that ICG in this novel anticancer nanoplatform can be triggered impressively by 808-nm irradiation to produce both a photothermal effect and cytotoxic reactive oxygen species (ROS), thus achieving a good PTT/PDT synergistic effect. Notably, compared with free ICG molecules, UPI nanocomposites show much higher photostability and thermal stability. Both in vitro and in vivo experiments show that the as-obtained UPI can ablate cancer cells effectively with 808-nm irradiation, revealing their great potential as a NIR-mediated dual-modal therapeutic platform. Meanwhile, the core of UCNPs can be used for UCL imaging. All these results demonstrate great potentiality of UPI as a novel type of theranostic agent for the treatment of tumors.

Fe2O3/TiO2 Tube-like Nanostructures: Synthesis, Structural Transformation and the Enhanced Sensing Properties

Abstract: The paper describes for the first time the successful synthesis of Fe2O3/TiO2 tube-like nanostructures, in which TiO2 shell is of quasi-single crystalline characteristic and its thickness can be controlled through adjusting the added amount of aqueous Ti(SO4)2 solution. The characterization of samples obtained at different stages using transmission electron microscope indicates that the outer TiO2 shell is changed gradually from amorphous and polycrystalline phase into quasi-single crystal under thermal actions through the Ostwald ripening process, accompanying the corrosion of the central parts of Fe2O3 nanorods, and the formation of small particles separating each other, leading to the special core/shell nanorods. Furthermore, Fe2O3/TiO2 tube-like nanostructures can be transformed into Fe2TiO5 nanostructures after they are thermally treated at higher temperatures. Those nanostructures exhibit enhanced ethanol sensing properties with respect to the monocomponent. Our results imply that not only hollow na...