Harbin Engineering University

About: Harbin Engineering University is a education organization based out in Harbin, Heilongjiang, China. It is known for research contribution in the topics: Control theory & Microstructure. The organization has 31149 authors who have published 27940 publications receiving 276787 citations. The organization is also known as: HEU.

Stimuli responsive drug delivery application of polymer and silica in biomedicine.

Abstract: In the last decade, using polymer and mesoporous silica materials as efficient drug delivery carriers has attracted great attention. Although the development and application of them involves some inevitable barriers, such as chronic toxicities, long-term stability, understanding of the biological fate and physiochemical properties, biodistribution, effect in the biological environment, circulation properties and targeting efficacy in vivo. The construction of stimuli responsive drug carriers using biologically safe materials, followed by hydrophilic modification, bioconjugation, targeting functionalization, and detailed safety analysis in small/large animal models may be the best way to overcome these barriers. Huge progress has been made in stimuli responsive drug delivery systems based on polymer and mesoporous silica materials, mainly including pH-, thermo-, light-, enzyme-, redox-, magnetic field- and ultrasound-responsive drug delivery systems, all of which are highlighted in this review.

Yolk-Structured Upconversion Nanoparticles with Biodegradable Silica Shell for FRET Sensing of Drug Release and Imaging-Guided Chemotherapy

Abstract: Silica related nanovehicles are being widely studied for bioapplication, while the use in vivo has been restricted due to the biodegradation reluctance. Herein, a facile Mn-doping method was used to endow the upconversion nanoparticles (UCNPs) with a biodegradable shell, simply by transforming mesoporous silica coated UCNPs (UCNPs@mSiO2) to Mn-doped upconversion nanocapsules (Mn-UCNCs). The yolk-structured Mn-UCNCs have huge internal space, which is greatly beneficial for DOX (a chemotherapeutic agent) storage. Furthermore, the Mn-doped nanoshell is responsive to mild reductive and acidic tumor condition, which enables the biodegradation of the silica shell in tumor sites and further accelerates the breakup of Si–O–Si bonds within the silica framework. This tumor-sensitive degradation of the shell not only facilitates DOX release in the tumor location but also allows faster nanoparticle diffusion and deeper tumor penetration, thus realizing efficient particle distribution and improved chemotherapy. Moreov...