Harborview Medical Center

About: Harborview Medical Center is a healthcare organization based out in Seattle, Washington, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 2476 authors who have published 2826 publications receiving 124680 citations.

Incidence and Outcomes of Acute Lung Injury

Abstract: BACKGROUND Acute lung injury is a critical illness syndrome consisting of acute hypoxemic respiratory failure with bilateral pulmonary infiltrates that are not attributed to left atrial hypertension. Despite recent advances in our understanding of the mechanism and treatment of acute lung injury, its incidence and outcomes in the United States have been unclear. METHODS We conducted a prospective, population-based, cohort study in 21 hospitals in and around King County, Washington, from April 1999 through July 2000, using a validated screening protocol to identify patients who met the consensus criteria for acute lung injury. RESULTS A total of 1113 King County residents undergoing mechanical ventilation met the criteria for acute lung injury and were 15 years of age or older. On the basis of this figure, the crude incidence of acute lung injury was 78.9 per 100,000 person-years and the age-adjusted incidence was 86.2 per 100,000 person-years. The in-hospital mortality rate was 38.5 percent. The incidence of acute lung injury increased with age from 16 per 100,000 person-years for those 15 through 19 years of age to 306 per 100,000 person-years for those 75 through 84 years of age. Mortality increased with age from 24 percent for patients 15 through 19 years of age to 60 percent for patients 85 years of age or older (P<0.001). We estimate that each year in the United States there are 190,600 cases of acute lung injury, which are associated with 74,500 deaths and 3.6 million hospital days. CONCLUSIONS Acute lung injury has a substantial impact on public health, with an incidence in the United States that is considerably higher than previous reports have suggested.

Matrix metalloproteinases as modulators of inflammation and innate immunity

Abstract: As their name implies, matrix metalloproteinases are thought to be responsible for the turnover and degradation of the extracellular matrix. However, matrix degradation is neither the sole nor the main function of these proteinases. Indeed, as we discuss here, recent findings indicate that matrix metalloproteinases act on pro-inflammatory cytokines, chemokines and other proteins to regulate varied aspects of inflammation and immunity.

The MOS 36-Item Short Form Health Survey: reliability, validity, and preliminary findings in schizophrenic outpatients.

Abstract: Objectives The authors test the reliability and validity of the Medical Outcomes Study Short Form 36-Item Health Survey (SF-36) as a written, self-administered survey in outpatients with chronic schizophrenia. Methods Thirty-six schizophrenic outpatients completed a written and oral form of the SF-36. A psychiatrist rated the patients using the Brief Psychiatric Rating Scale to determine severity of psychopathology. Cognitive functioning and academic achievement were also assessed. Internal consistency, test-retest reliability, concurrent and discriminative validity of the oral and written versions were determined. Results The SF-36 in both forms was shown to have good internal consistency, stability, and concurrent validity. The mental health SF-36 subscales had poor discriminant validity, compared with the physical functioning scale that demonstrated good discriminant validity. Conclusions The validity of using the written form of the SF-36 on a sample of patients with chronic mental illness was demonstrated. The SF-36 appears to be an appropriate outcome measure for changes in physical and role functioning in consumers of outpatient mental health programs.

Fracture and Dislocation Classification Compendium-2018

Abstract: From the *Department of Orthopaedic Surgery, McGovern Medical School, University of Texas Health Sciences Center at Houston, ** Department of Orthopaedic Surgery, Zuckerberg San Francisco General Hospitial, University of California, San Francisco; *** Department of Orthopaedic Surgery, Harborview Medical Center, Seattle, **** University of Iowa Department of Orthopaedics and Rehabilitation, Iowa City, ***** Department of Orthopaedic Surgery; University of Louisville School of Medicine Disclosure: The authors report no conflicts of interest. Material presented in this Compendium is based on the Comprehensive Classification of Fractures of Long Bones by M.E. Müller, J. Nazarian, P. Koch and J. Schatzker, Springer-Verlag, Berlin, 1990. The Orthopaedic Trauma Association is indebted to Professor Maurice Müller for allowing use of the system. Correspondence: James F. Kellam, Department of Orthopaedic Surgery, McGovern Medical School, University of Texas Health Sciences Center at Houston, 6431 Fannin Street, MSB 6.146, Houston Texas, 77030 (e-mail: James.F.Kellam@uth.tmc.edu) Copyright © 2017 by AO Foundation, Davos, Switzerland; Orthopaedic Trauma Association, IL, US To encourage the use of this classification and this fracture classification compendium, the figures may be reproduced and the classification may be used for research, educational and or medical purposes without the need to request permission from the OTA, AO Foundation or the publisher. It cannot be used commercially or for-profit without permission. Foreword

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons

Abstract: Neuropeptide Y (NPY) stimulates food intake and promotes weight gain, whereas melanocortins have the opposite effect. Yet both peptides are synthesized in the arcuate nucleus, a hypothalamic area involved in energy homeostasis. We report here that mRNA encoding NPY and the melanocortin precursor, proopiomelanocortin (POMC) are expressed in adjacent, but distinct, subpopulations of arcuate nucleus neurons. Moreover, these NPY neurons coexpress mRNA encoding Agouti-related protein (Agrp), an endogenous melanocortin receptor antagonist, and fasting increases the expression of both of these mRNA species. Our findings suggest that hypothalamic NPY/Agrp neurons constitute a unique cell type that is activated by fasting to stimulate food intake via a simultaneous increase of NPY and decrease of melanocortin.