scispace - formally typeset
Search or ask a question
Institution

Harold Grinspoon Foundation

About: Harold Grinspoon Foundation is a based out in . It is known for research contribution in the topics: Tinnitus & Presbycusis. The organization has 19 authors who have published 11 publications receiving 198 citations.

Papers
More filters
Journal ArticleDOI
TL;DR: In this article, the authors measured the branchings of very neutron-rich nuclides in the Co-Zn region at the National Superconducting Cyclotron Laboratory using the NSCL {beta}-counting station in conjunction with the neutron detector NERO.
Abstract: The {beta} decays of very neutron-rich nuclides in the Co-Zn region were studied experimentally at the National Superconducting Cyclotron Laboratory using the NSCL {beta}-counting station in conjunction with the neutron detector NERO. We measured the branchings for {beta}-delayed neutron emission (P{sub n} values) for {sup 74}Co (18{+-}15%) and {sup 75-77}Ni (10{+-}2.8%, 14{+-}3.6%, and 30{+-}24%, respectively) for the first time, and remeasured the P{sub n} values of {sup 77-79}Cu, {sup 79,81}Zn, and {sup 82}Ga. For {sup 77-79}Cu and for {sup 81}Zn we obtain significantly larger P{sub n} values compared to previous work. While the new half-lives for the Ni isotopes from this experiment had been reported before, we present here in addition the first half-life measurements of {sup 75}Co (30{+-}11 ms) and {sup 80}Cu (170{sub -50}{sup +110} ms). Our results are compared with theoretical predictions, and their impact on various types of models for the astrophysical rapid neutron-capture process (r-process) is explored. We find that with our new data, the classical r-process model is better able to reproduce the A=78-80 abundance pattern inferred from the solar abundances. The new data also influence r-process models based on the neutrino-driven high-entropy winds in core collapse supernovae.

59 citations

Journal ArticleDOI
TL;DR: Tinnitus has a relevant impact on the lives of the elderly; there was no correlation between the level of hearing loss and thelevel of patient dissatisfaction caused by tinnitus; and presbycusis was the most common finding in the audiometric tests.
Abstract: Summary Population aging it is a current reality in Brazil and tinnitus appears as a very prevalent symptom, having a high impact on the quality of life of elderly patients. Aim to evaluate and to characterize tinnitus in this group. Materials and Methods A research questionnaire randomly given to 100 elderly patients in a tertiary hospital, asking about tinnitus characteristics, its impact on the life of the patient, and personal medical history. Results 61% of the participants were female, average age average was 69.53 years. Conclusions Tinnitus has a relevant impact on the lives of the elderly; there was no correlation between the level of hearing loss and the level of patient dissatisfaction caused by tinnitus; and presbycusis was the most common finding in the audiometric tests.

42 citations

Journal ArticleDOI
TL;DR: Tinnitus has a relevant impact on the lives of the elderly; there was no correlation between the level of hearing loss and thelevel of patient dissatisfaction caused by tinnitus; and presbycusis was the most common finding in the audiometric tests.
Abstract: Population aging it is a current reality in Brazil and tinnitus appears as a very prevalent symptom, having a high impact on the quality of life of elderly patients AIM: to evaluate and to characterize tinnitus in this group MATERIALS AND METHODS: A research questionnaire randomly given to 100 elderly patients in a tertiary hospital, asking about tinnitus characteristics, its impact on the life of the patient, and personal medical history RESULTS: 61% of the participants were female, average age average was 6953 years The results associated with tinnitus features were: no-pulsatile 76%, continuous 54%, bilateral 57%, recent 62% and alone 83%;32,5% had emotional disorders, 318% had sleep disorders, 225% had difficulties concentration and 132% had social problems; 39% classified their tinnitus in moderate; 35% had intense tinnitus and 26% considered it a mild one: as to comorbidities: relation with neurotology symptoms and hypertension; as for associations with audiometry findings: descending, sensorineural and symmetrical curves prevailed CONCLUSIONS: Tinnitus has a relevant impact on the lives of the elderly; there was no correlation between the level of hearing loss and the level of patient dissatisfaction caused by tinnitus; and presbycusis was the most common finding in the audiometric tests

33 citations

Journal ArticleDOI
TL;DR: As anormalidades musculoesqueleticas em pacientes submetidos a hemodialise sao numerosas e frequentes, sendo mais prevalentes naqueles em tratamento dialitico de longa duracao.
Abstract: As anormalidades musculoesqueleticas em pacientes submetidos a hemodialise sao numerosas e frequentes, sendo mais prevalentes naqueles em tratamento dialitico de longa duracao. A artralgia e o sintoma mais comum, ocorrendo em mais de 70% dos pacientes. O hiperparatireoidismo secundario e a principal causa da doenca renal ossea, e as manifestacoes clinicas sao: dor ossea, artralgia e prurido. A amiloidose, decorrente da deposicao de proteina b2-microglobulina nos tecidos, manifesta-se pela presenca de ombro doloroso, sindrome do tunel do carpo, dedo em gatilho, ruptura espontânea de tendao e fratura patologica. Outras manifestacoes musculoesqueleticas observadas sao a artrite induzida por cristais, necrose avascular, artrite septica, fraqueza muscular e caibras musculares.

28 citations

Journal ArticleDOI
TL;DR: The low prevalence of PPD reaction in this Brazilian population, mainly in chronic patients, with the worst performance among RA patients, showed that the test has limited value for diagnosis of tuberculosis infection in candidates to infliximab therapy.
Abstract: OBJECTIVE: To identify tuberculosis infection in rheumatic patients on infliximab by use of PPD testing prior to immunobiologic therapy. METHODS: This study comprised 157 patients undergoing infliximab treatment and 734 other patients undergoing laboratory screening for tuberculosis infection originating from several services. The Mantoux technique was used for PPD testing, and an induration of at least 5 mm was considered reactive status. RESULTS: In the infliximab group, 13% of the patients reacted to PPD, while, in the other group, 27% of the patients reacted to PPD (χ2 = 13; P = 0.0003). These patients were divided into categories: adults with chronic diseases, PPD reactivity of 22%; and other controls, PPD reactivity of 31%. This shows the heterogeneous response of that population (χ2 = 7; P < 0.009). In the infliximab group, subdivided according to pathologies [rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic arthritis (PA)], different reactivity rates were observed, the lowest value occurring among RA patients: (RA x AS: OR = 0.13; CI: 0.03-0.47; χ2 = 12; P = 0.0004) and (RA x PA: OR = 0.16; CI: 0.02-1.04; χ2Yates corrected = 3.6; P = 0.05). The PPD reactivity in the RA subgroup (4%) was also lower as compared with that of the chronic patients group (22%) (OR = 0.16; CI: 0.05-0.49; χ2 = 14; P = 0.0002), even when reclassified into four subgroups: rheumatology (OR = 0.19; CI: 0.04-0.72), kidney transplantation (OR = 0.16; CI: 0.05-0.51), infectology (OR = 0.21; CI: 0.05-0.75), and other conditions (OR = 0.13; CI: 0.04-0.44). CONCLUSION: The low prevalence of PPD reaction in this Brazilian population, mainly in chronic patients, with the worst performance among RA patients, shwoed that the test has limited value for diagnosis of tuberculosis infection in candidates to infliximab therapy

19 citations


Network Information
Related Institutions (5)
Hospital de Base
1K papers, 14.5K citations

83% related

Faculdade de Medicina de Marília
799 papers, 7.6K citations

82% related

Faculdade de Medicina de São José do Rio Preto
1.8K papers, 24.7K citations

81% related

Pontifícia Universidade Católica de Campinas
3.8K papers, 30.3K citations

79% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20132
20112
20102
20093
20052