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Institution

Heart and Diabetes Center North Rhine-Westphalia

HealthcareBad Oeynhausen, Germany
About: Heart and Diabetes Center North Rhine-Westphalia is a healthcare organization based out in Bad Oeynhausen, Germany. It is known for research contribution in the topics: Vitamin D and neurology & Heart failure. The organization has 288 authors who have published 357 publications receiving 9276 citations.


Papers
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Journal ArticleDOI
23 Dec 2015-PLOS ONE
TL;DR: A sensitive and specific UPLC-MRM MS assay for the quick and specific measurement of dabigatran and rivaroxaban in human plasma has a much better selectivity than classical functional assays measuring activities of various coagulation factors which are susceptible to interference by other coagulant drugs.
Abstract: Introduction The fast, precise, and accurate measurement of the new generation of oral anticoagulants such as dabigatran and rivaroxaban in patients’ plasma my provide important information in different clinical circumstances such as in the case of suspicion of overdose, when patients switch from existing oral anticoagulant, in patients with hepatic or renal impairment, by concomitant use of interaction drugs, or to assess anticoagulant concentration in patients’ blood before major surgery.

35 citations

Journal ArticleDOI
TL;DR: Centrifugal continuous flow pumps are currently the state of the art in left ventricular assist device therapy and the results after implantation of the HVAD® and the HeartMate 3® are compared.
Abstract: Aims Centrifugal continuous flow pumps are currently the state of the art in left ventricular assist device therapy. This study was conducted to compare the results after implantation of the HVAD® and the HeartMate 3®. Methods and results We retrospectively analysed preoperative and post-operative patient data of all 106 patients, who received a HeartMate 3 (HM3) at our centre between 2014 and 2018. A total of 392 patients receiving a sintered HVAD® served as controls. Patient matching was performed for age, sex, Interagency Registry for Mechanically Assisted Circulatory Support level at the time of implant, perioperative right heart failure, and implantation strategy, that is, bridge to transplant or destination therapy, as well as preoperative renal function, that is, as indicated by serum creatinine levels. A total of 79 matched pairs could be identified. During a median follow-up of 15.3 months (range: 0-30 months), 23 (29.1%) and 19 (24.1%) patients died in the HVAD and HM3 groups, respectively, with a hazard ratio for mortality of 0.84 [95% confidence interval (CI): 0.46-1.54; P = 0.568]. Freedom from cerebrovascular events did not differ significantly between study groups, with a hazard ratio of 0.57 (95% CI: 0.23-1.45; P = 0.241). The risk of driveline infection was significantly lower in the HM3 (n = 33) than in the HVAD (n = 55) group (hazard ratio = 0.54; 95% CI: 0.35-0.84; P = 0.006). Eight HVAD, but no HM3, patients developed a pump thrombosis during follow-up (P = 0.148). Conclusions Performance of both currently used centrifugal left ventricular assist device systems is comparable in terms of short-term patient survival and freedom from cerebrovascular events. In our single-centre experience, HM3 patients less frequently develop driveline infections and no pump thrombosis, which requires further evaluation.

34 citations

Journal ArticleDOI
TL;DR: The extent of allowed physical activity is dependant on the size of the left atrium and severity of the valve defect as mentioned in this paper, and the severity of aortic valve regurgitation.
Abstract: Physical check-ups among athletes with valvular heart disease are of significant relevance. In athletes with mitral valve stenosis the extent of allowed physical activity is dependant on the size of the left atrium and the severity of the valve defect. Patients with mild-to-moderate mitral valve regurgitation can participate in all types of sport associated with low and moderate isometric stress and moderate dynamic stress. Patients under anticoagulation should not participate in any type of contact sport. Asymptomatic athletes with mild aortic valve stenosis can take part in all types of sport, as long as left ventricular function and size are normal, a normal response to exercise at the level performed during athletic activities is present and there are no arrhythmias. Asymptomatic athletes with moderate aortic valve stenosis should only take part in sports with low dynamic and static stress. Aortic valve regurgitation is often present due to connective tissue disease of a bicuspid valve. Athletes with mild aortic valve regurgitation, with normal end diastolic left ventricular size and systolic function can participate in all types of sport. A mitral valve prolapse is often associated with structural diseases of the myocardium and endocardium. In patients with mitral valve prolapse Holter-ECG monitoring should also be performed to detect significant arrhythmias. All athletes with known valvular heart disease, a previous history of infective endocarditis and valve surgery should receive endocarditis prophylaxis before dental, oral, respiratory, intestinal and genitourinary procedures associated with bacteraemia. Sport activities have to be avoided during active infection with fever.

34 citations

Journal ArticleDOI
TL;DR: Sleep-disordered breathing (SDB) has a prognostic impact in patients with cardiac diseases and seems to be associated with chronic inflammation, which may be linked to CAD progression and/or acute coronary events.
Abstract: Sleep-disordered breathing (SDB) has a prognostic impact in patients with cardiac diseases We included 257 patients with preserved left ventricular function and angiographically proven coronary artery disease (CAD) All patients underwent cardiorespiratory polygraphy In 251 patients high-sensitive C-reactive protein and fibrinogen were measured SDB was documented in 188 patients (apnea-hypopnea-index [AHI] 164± 19/h): 58 patients presented central sleep apnea (CSA) and 130 patients obstructive sleep apnea (OSA) All patients (73%) with SDB had higher blood fibrinogen levels than those without SDB (p = 001) We found 197 patients with CRP-values below the cut-off of 05 mg/dl (group 1) and 54 patients with no active infection but CRP>05 mg/dl (group 2) Severity of SDB was significantly higher in group 2 (p = 001) SDB has a high prevalence in CAD patients and seems to be associated with chronic inflammation, which may be linked to CAD progression and/or acute coronary events

34 citations

Journal ArticleDOI
TL;DR: The results indicate that changes of Bruch membrane can be associated with choroidal alterations, which are most pronounced in the presence of advanced disease.

34 citations


Authors

Showing all 303 results

NameH-indexPapersCitations
Jan Gummert5529010570
Armin Zittermann5425212697
Dieter Horstkotte4545710554
Andreas Koster411905602
Reiner Körfer392405546
Jan D. Schmitto382965560
Reiner Koerfer381905844
Philipp Beerbaum381474769
Jochen Börgermann351473814
Jens Dreier351143472
Tanja K. Rudolph351183780
Joachim Kuhn351424226
Christian Götting351094349
Aly El-Banayosy341424652
Olaf Oldenburg341844736
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20231
202229
202121
202022
201916
201820