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Institution

Heart and Diabetes Center North Rhine-Westphalia

HealthcareBad Oeynhausen, Germany
About: Heart and Diabetes Center North Rhine-Westphalia is a healthcare organization based out in Bad Oeynhausen, Germany. It is known for research contribution in the topics: Vitamin D and neurology & Heart failure. The organization has 288 authors who have published 357 publications receiving 9276 citations.


Papers
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Journal ArticleDOI
TL;DR: Impacts on inflammation and metabolic dysregulation display the complex interplay between breathing disorders and evolution and progression of atrial fibrillation.
Abstract: This review illustrates the importance of sleep disordered breathing in evolution and progression of atrial fibrillation. While in early years associations were mainly attributed to the impact of hypoxemia and hypertension, nowadays multiple, additional pathways have been investigated or are currently under investigation. Sleep disordered breathing has been shown to have a direct impact on mechanical and electrical remodeling. In addition hypercapnia and negative intrathoracic pressure seem to alter atrial electrophysiology. Finally, impacts on inflammation and metabolic dysregulation display the complex interplay between breathing disorders and evolution and progression of atrial fibrillation.

3 citations

Journal ArticleDOI
TL;DR: Thorax diameter or defect diameter of giant omphaloceles is not predictive for fetal outcome and perinatal care of these abdominal wall defects still remains a multidisciplinary challenge, but the outcome of giant OmphaloCEles is favorable at experienced centers.
Abstract: To investigate the relationship between the thorax diameter and defect diameter of giant omphaloceles as a predictor for fetal outcome. In a retrospective study, 17 fetuses with isolated giant omphaloceles were included for evaluation. The anterior–posterior thorax diameter and the defect diameter were measured from ultrasound images. For analysis, the thorax-to-head ratio (T/HC), the defect diameter-to-head ratio (DD/HC), and the quotient of the defect diameter and the thorax diameter (DD/T) were calculated. The days of ventilation (t ventilation), the duration until hospital discharge (t hospital), and the type of treatment were recorded as outcome parameters. No relationship was found between the calculated ratios (T/HC, DD/HC, or DD/T) and neither t hospital (r = −0.418, p = 0.095; r = −0.153, p = 0.556; and r = −0.023, p = 0.929; respectively) nor t ventilation (r = −0.391, p = 0.121; r = 0.041, p = 0.875; and r = 0.121, p = 0.645, respectively). The type of postnatal treatment was not associated with the three calculated ratios or t hospital (r = 0.155, p = 0.553; r = 0.019, p = 0.942; and r = 0.012, p = 0.965; r = −0.009, p = 0.973, respectively). In 53% of cases, t hospital was delayed due to additional and independent postnatal complications. Thorax diameter or defect diameter of giant omphaloceles is not predictive for fetal outcome. The perinatal care of these abdominal wall defects still remains a multidisciplinary challenge, but the outcome of giant omphaloceles is favorable at experienced centers.

3 citations

Journal ArticleDOI
02 Jul 2018-PLOS ONE
TL;DR: Atrial radial PS and TTPS determinations are possible in the fetus, and the transverse FCV is best suited for these.
Abstract: Aims To determine if atrial tissue deformation (peak strain, PS) and time to peak strain (TTPS) can be assessed in the fetus, with identification of best echocardiographic plane. Materials and methods Pulsed-wave tissue Doppler study of a longitudinal and a transverse four-chamber view (FCV) in each of 20 healthy fetuses. Determination of PS and TTPS in regions of interest (ROI), viz., lateral walls of the right and left atria (RA, LA); comparison of values depending on section plane, with results-based discussion of the physiology of fetal atrial deformation and of possible clinical uses. Results PS and TTPS could be determined on transverse FCV in 91% of subjects and in 61% on longitudinal FCV. Transverse PS and TTPS were significantly higher than longitudinal (p = 0.0001). Transverse PS was significantly higher in RA than in LA (26.9% vs. 17.3%, p = 0.034), and transverse TTPS was significantly shorter in RA than in LA (p = 0.034). Conclusion Atrial radial PS and TTPS determinations are possible in the fetus. The transverse FCV is best suited for these. The highest PS values and shortest TTPS values are found in ROI representing the RA. Our findings may contribute to detailed intrauterine assessment of atrial and ventricular myocardial function.

3 citations

Journal Article
TL;DR: In this paper, a prospective trial utilizing positron emission tomography (PET) was conducted as an attempt to correlate quantified myocardial blood flow (MBF) to clinical improvement following percutaneous Myocardial revascularization (PMR) in patients with persistent refractory angina due to end-stage coronary artery disease.
Abstract: BACKGROUND: Reportedly, patients with persistent refractory angina due to end-stage coronary artery disease (CAD) not amenable to traditional revascularization techniques have experienced symptomatic relief following laser revascularization, either surgical transmyocardial revascularization (TMR) or percutaneous myocardial revascularization (PMR). In spite of several hypotheses (i.e., channel patency, placebo effect, denervation, neoangiogenesis), the mechanism of action and the benefit remains controversial. METHODS: A prospective trial utilizing positron emission tomography (PET) was conducted as an attempt to correlate quantified myocardial blood flow (MBF) to clinical improvement following PMR. Thirteen consecutive patients with angina class > II in spite of maximal medical treatment underwent PMR with a holmium: yttrium-aluminum-garnet (Ho:YAG) laser. MBF at rest and under hyperemia was assessed by [(13)N]ammonia PET at baseline, 3 and 6 months following PMR. RESULTS: Mean angina class and exercise tolerance time improved at 6 months compared with baseline (P < 0.001). The clinical results were accompanied with an improvement in hyperemic MBF (P = 0.05) and a reduction in minimal coronary resistance (MCR; P < 0.05) in PMR-treated segments. Opposite effects, reduced hyperemic MBF and increased MCR, were observed in nontreated segments. The increase in MCR in nontreated segments revealed the favorable therapeutic impact achieved in PMR-treated segments. CONCLUSION: The results of this trial utilizing a quantitative technique to quantify myocardial perfusion link clinical improvement post-PMR to neoangiogenesis and consistently improved microcirculation.

3 citations

Journal ArticleDOI
TL;DR: This approach is a simple alternative technique that can be used when anatomic prosthetic valve implantation is not feasible, and evasion of extensive debridement, implantation of an adequately sized prosthesis, and prosthetic material availability.

3 citations


Authors

Showing all 303 results

NameH-indexPapersCitations
Jan Gummert5529010570
Armin Zittermann5425212697
Dieter Horstkotte4545710554
Andreas Koster411905602
Reiner Körfer392405546
Jan D. Schmitto382965560
Reiner Koerfer381905844
Philipp Beerbaum381474769
Jochen Börgermann351473814
Jens Dreier351143472
Tanja K. Rudolph351183780
Joachim Kuhn351424226
Christian Götting351094349
Aly El-Banayosy341424652
Olaf Oldenburg341844736
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20231
202229
202121
202022
201916
201820