Institution
Hebei Normal University of Science and Technology
Education•Qinhuangdao, China•
About: Hebei Normal University of Science and Technology is a education organization based out in Qinhuangdao, China. It is known for research contribution in the topics: Phosphor & Photoluminescence excitation. The organization has 2079 authors who have published 1496 publications receiving 14827 citations.
Papers published on a yearly basis
Papers
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TL;DR: Two monoclonal antibodies isolated from a patient with COVID-19 are shown to interfere with SARS-CoV-2–receptor binding, and one displays potent action against this virus in vitro and in a rhesus macaque model.
Abstract: An outbreak of coronavirus disease 2019 (COVID-19)1-3, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)4, has spread globally. Countermeasures are needed to treat and prevent further dissemination of the virus. Here we report the isolation of two specific human monoclonal antibodies (termed CA1 and CB6) from a patient convalescing from COVID-19. CA1 and CB6 demonstrated potent SARS-CoV-2-specific neutralization activity in vitro. In addition, CB6 inhibited infection with SARS-CoV-2 in rhesus monkeys in both prophylactic and treatment settings. We also performed structural studies, which revealed that CB6 recognizes an epitope that overlaps with angiotensin-converting enzyme 2 (ACE2)-binding sites in the SARS-CoV-2 receptor-binding domain, and thereby interferes with virus-receptor interactions by both steric hindrance and direct competition for interface residues. Our results suggest that CB6 deserves further study as a candidate for translation to the clinic.
1,141 citations
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TL;DR: The aim of this paper was to summarize the recent investigations and findings regarding in vitro and animal model studies on the anti-inflammatory effects of fruits, vegetables, and food legumes and phytochemicals are discussed as the natural promotion strategy for the improvement of human health status.
Abstract: Inflammation is the first biological response of the immune system to infection, injury or irritation. Evidence suggests that the anti-inflammatory effect is mediated through the regulation of various inflammatory cytokines, such as nitric oxide, interleukins, tumor necrosis factor alpha-α, interferon gamma-γ as well as noncytokine mediator, prostaglandin E2. Fruits, vegetables, and food legumes contain high levels of phytochemicals that show anti-inflammatory effect, but their mechanisms of actions have not been completely identified. The aim of this paper was to summarize the recent investigations and findings regarding in vitro and animal model studies on the anti-inflammatory effects of fruits, vegetables, and food legumes. Specific cytokines released for specific type of physiological event might shed some light on the specific use of each source of phytochemicals that can benefit to counter the inflammatory response. As natural modulators of proinflammatory gene expressions, phytochemical from fruits, vegetables, and food legumes could be incorporated into novel bioactive anti-inflammatory formulations of various nutraceuticals and pharmaceuticals. Finally, these phytochemicals are discussed as the natural promotion strategy for the improvement of human health status. The phenolics and triterpenoids in fruits and vegetables showed higher anti-inflammatory activity than other compounds. In food legumes, lectins and peptides had anti-inflammatory activity in most cases. However, there are lack of human study data on the anti-inflammatory activity of phytochemicals from fruits, vegetables, and food legumes.
275 citations
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TL;DR: In this article, the authors present an overview on the production technologies of β-glucan, such as extraction, isolation, purification technologies from different sources, for instance yeast, fungi, bacteria, and cereal, aiming its optimization for more effective production processes.
260 citations
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TL;DR: Of these, β-Gal and α- l -Af may be more closely related to the storability of apples than PG and PME, especially when fruit ripening and softening begin, and were obviously regulated by ethylene and 0 °C.
197 citations
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TL;DR: In this paper, a review summarizes the extraction, purification, quantification, and structural characterization of β-glucans from mushrooms, along with chemical and biological activities from this compound from mushrooms.
190 citations
Authors
Showing all 2082 results
Name | H-index | Papers | Citations |
---|---|---|---|
Bin Du | 19 | 40 | 1463 |
X.Y. Zhang | 18 | 105 | 1272 |
Zhi-wei Zhang | 17 | 82 | 927 |
S. F. Li | 17 | 28 | 769 |
Guojing Wang | 17 | 42 | 765 |
Ming Fang | 16 | 36 | 631 |
Xinwu Ba | 16 | 72 | 770 |
Xiufeng Lang | 16 | 25 | 909 |
Bo Wang | 15 | 158 | 1019 |
Xian-Fu Zhang | 14 | 23 | 611 |
Dong-jun Wang | 13 | 31 | 453 |
Chunlei Guo | 13 | 17 | 483 |
Shudi Lu | 11 | 25 | 348 |
Ya-jie Han | 11 | 40 | 367 |
Lei Shi | 11 | 36 | 361 |