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Institution

Hellenic Military Academy

EducationVoula, Greece
About: Hellenic Military Academy is a education organization based out in Voula, Greece. It is known for research contribution in the topics: Complex space & Jacobi operator. The organization has 36 authors who have published 97 publications receiving 541 citations.


Papers
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Journal ArticleDOI
TL;DR: Two potent direct inhibitors of TNF function with low micromolar IC50 values and minimal toxicity even at high concentrations are identified and could serve as lead compounds for the development of novel treatments for inflammatory and autoimmune diseases.
Abstract: An in silico drug discovery pipeline for the virtual screening of plant-origin natural products (NPs) was developed to explore new direct inhibitors of TNF and its close relative receptor activator of nuclear factor kappa-B ligand (RANKL), both representing attractive therapeutic targets for many chronic inflammatory conditions. Direct TNF inhibition through identification of potent small molecules is a highly desired goal; however, it is often hampered by severe limitations. Our approach yielded a priority list of 15 NPs as potential direct TNF inhibitors that were subsequently tested in vitro against TNF and RANKL. We thus identified two potent direct inhibitors of TNF function with low micromolar IC50 values and minimal toxicity even at high concentrations. Most importantly, one of them (A11) was proved to be a dual inhibitor of both TNF and RANKL. Extended molecular dynamics simulations with the fully automated EnalosMD suite rationalized the mode of action of the compounds at the molecular level. To our knowledge, these compounds constitute the first NP TNF inhibitors, one of which being the first NP small-molecule dual inhibitor of TNF and RANKL, and could serve as lead compounds for the development of novel treatments for inflammatory and autoimmune diseases.

15 citations

Proceedings ArticleDOI
23 Oct 1996
TL;DR: This approach to off-line optical character recognition for hand-written or printed characters using for feature extraction and classification biorthogonal discrete wavelet transform achieves great recognition accuracy and font insensitivity requiring only a small training set of characters.
Abstract: We present an approach to off-line optical character recognition for hand-written or printed characters using for feature extraction and classification biorthogonal discrete wavelet transform. Our aim is to optimize character recognition methods independently of printing styles, writing styles and fonts used. Characters are identified with their contours, thus characterized from their curvature function. Curvature function is used for feature extraction while classification is accomplished by LVQ algorithms. This method achieves great recognition accuracy and font insensitivity requiring only a small training set of characters.

13 citations

Journal ArticleDOI
TL;DR: It was concluded that DAT can be a potential tool to evaluate the dribbling performance in young soccer players and can differentiate the dribbled skill between groups.
Abstract: The present study examined the construct validity and reliability of a new dribbling agility test (DAT) that incorporates reactive agility and multiple change of direction. To check its' validity, (a) DAT was performed by four groups (under 10, under 12, under 14 and under 16 yrs) of young soccer players (n = 125 in each group) and (b) a regression analysis was conducted to define the best DAT predictors. The reliability of DAT was assessed with repeated measurements. This test can differentiate the dribbling skill between groups (p < 0.01). Furthermore, 68% of the observed variance in DAT was explained by zigzag dribbling test, Illinois agility test, reaction time and running speed. The test-retest reliability was high in all groups (ICC = 0.77 - 0.90, p < 0.01). It was concluded that DAT can be a potential tool to evaluate the dribbling performance in young soccer players.

13 citations

Book ChapterDOI
11 Sep 2017
TL;DR: This chapter proposes a generic and flexible protocol for VGI data collection, which can be applied to new as well as to existing projects regardless of the specific type of geospatial information collected.
Abstract: Volunteered Geographic Information (VGI) has become a rich and well established source of geospatial data. From the popular OpenStreetMap (OSM) to many citizen science projects and social network platforms, the amount of geographically referenced information that is constantly being generated by citizens is burgeoning. The main issue that continues to hamper the full exploitation of VGI lies in its quality, which is by its nature typically undocumented and can range from very high quality to very poor. A crucial step towards improving VGI quality, which impacts on VGI usability, is the development and adoption of protocols, guidelines and best practices to assist users when collecting VGI. This chapter proposes a generic and flexible protocol for VGI data collection, which can be applied to new as well as to existing projects regardless of the specific type of geospatial information collected. The protocol is meant to balance the contrasting needs of providing VGI contributors with precise and detailed instructions while maintaining and growing the enthusiasm and motivation of contributors. Two real-world applications of the protocol are presented, which guide the collection of VGI in respectively the generation and updating of thematic information in a topographic building database; and the uploading of geotagged photographs for the improvement of land use and land cover maps. Technology is highlighted as a key factor in determining the success of the protocol implementation.

10 citations

Proceedings Article
27 Jan 2010
TL;DR: This work presents a methodology for the development of dynamic virtual reality applications for commercial use, where the owner can dynamically upload and manage its own products online (description, prices, multimedia material).
Abstract: This work presents a methodology for the development of dynamic virtual reality applications for commercial use. Through a combination of state of the art technologies and methods, thee-dimensional representations of the real world (stores, buildings, etc) result in being independent of the objects they embody. The location and allocation of the objects in the virtual world and all information about them are dynamically set by administrators. These users in a "What You See Is What You Get" (WYSIWYG) web environment can add/change/rearrange the objects in the virtual world, along with the information about them. This methodology has been implemented with the combination of common software for developing 3D models, JavaScript, a custom .net web application and an XML data source. A paradigm of a virtual store is presented, where the owner can dynamically upload and manage its own products online (description, prices, multimedia material).

10 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20233
20227
202111
202012
20195
20186