Institution
Helsinki Institute for Information Technology
Facility•Espoo, Finland•
About: Helsinki Institute for Information Technology is a facility organization based out in Espoo, Finland. It is known for research contribution in the topics: Population & Bayesian network. The organization has 630 authors who have published 1962 publications receiving 63426 citations.
Papers published on a yearly basis
Papers
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TL;DR: Women aged below 30 and from the most deprived areas were at highest risk of depression and most likely to receive antidepressant treatment and more than one in eight women received antidepressant treatment in this period.
Abstract: Objectives To investigate how depression is recognised in the year after child birth and treatment given in clinical practice. Design Cohort study based on UK primary care electronic health records. Setting Primary care. Participants Women who have given live birth between 2000 and 2013. Outcomes Prevalence of postnatal depression, depression diagnoses, depressive symptoms, antidepressant and non-pharmacological treatment within a year after birth. Results Of 206 517 women, 23 623 (11%) had a record of depressive diagnosis or symptoms in the year after delivery and more than one in eight women received antidepressant treatment. Recording and treatment peaked 6–8 weeks after delivery. Initiation of selective serotonin reuptake inhibitors (SSRI) treatment has become earlier in the more recent years. Thus, the initiation rate of SSRI treatment per 100 pregnancies (95% CI) at 8 weeks were 2.6 (2.5 to 2.8) in 2000–2004, increasing to 3.0 (2.9 to 3.1) in 2005–2009 and 3.8 (3.6 to 3.9) in 2010–2013. The overall rate of initiation of SSRI within the year after delivery, however, has not changed noticeably. A third of the women had at least one record suggestive of depression at any time prior to delivery and of these one in four received SSRI treatment in the year after delivery. Younger women were most likely to have records of depression and depressive symptoms. (Relative risk for postnatal depression: age 15–19: 1.92 (1.76 to 2.10), age 20–24: 1.49 (1.39 to 1.59) versus age 30–34). The risk of depression, postnatal depression and depressive symptoms increased with increasing social deprivation. Conclusions More than 1 in 10 women had electronic health records indicating depression diagnoses or depressive symptoms within a year after delivery and more than one in eight women received antidepressant treatment in this period. Women aged below 30 and from the most deprived areas were at highest risk of depression and most likely to receive antidepressant treatment.
24 citations
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TL;DR: This paper shows, using different metabolomics measurement batches as the views so that the ground truth is known, that the metabolite identities can be reliably matched by a consensus of several matching solutions.
Abstract: Multi-view learning studies how several views, different feature representations, of the same objects could be best utilized in learning. In other words, multi-view learning is analysis of co-occurrence data, where the observations are co-occurrences of samples in the views. Standard multi-view learning such as joint density modeling cannot be done in the absence of co-occurrence, when the views are observed separately and the identities of objects are not known. As a practical example, joint analysis of mRNA and protein concentrations requires mapping between genes and proteins. We introduce a data-driven approach for learning the correspondence of the observations in the different views, in order to enable joint analysis also in the absence of known co-occurrence. The method finds a matching that maximizes statistical dependency between the views, which is particularly suitable for multi-view methods such as canonical correlation analysis which has the same objective. We apply the method to translational metabolomics, to identify differences and commonalities in metabolic processes in different species or tissues. The metabolite identities and roles in the different species are not generally known, and it is necessary to search for a matching. In this paper we show, using different metabolomics measurement batches as the views so that the ground truth is known, that the metabolite identities can be reliably matched by a consensus of several matching solutions.
23 citations
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08 Jun 2015TL;DR: This work proposes a proxy-based key establishment protocol for the IoT, which enables any two unknown high resource constrained devices to initiate secure E2E communication and demonstrates the applicability of the solution in constrained IoT devices by providing performance and security analysis.
Abstract: The Internet of Things (IoT) drives the world towards an always connected paradigm by interconnecting wide ranges of network devices irrespective of their resource capabilities and local networks. This would inevitably enhance the requirements of constructing dynamic and secure end-to-end (E2E)connections among the heterogenous network devices with imbalanced resource profiles and less or no previous knowledge about each other. The device constraints and the dynamic link creations make it challenging to use pre-shared keys for every secure E2E communication scenario in IoT. We propose a proxy-based key establishment protocol for the IoT, which enables any two unknown high resource constrained devices to initiate secure E2E communication. The high constrained devices should be legitimate and maintain secured connections with the neighbouring less constrained devices in the local networks, in which they are deployed. The less constrained devices are performing as the proxies and collaboratively advocate the expensive cryptographic operations during the session key computation. Finally, we demonstrate the applicability of our solution in constrained IoT devices by providing performance and security analysis.
23 citations
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20 Sep 2004TL;DR: This work applies topic modelling to an online financial newspaper data and shows that some of the trends in the topics are consistent with common understanding.
Abstract: Topic-based search engines are an alternative to simple keyword search engines that are common in today's intranets. The temporal behaviour of the topics in a topic model based search engine can be used for trend analysis, which is an important research goal on its own. We apply topic modelling to an online financial newspaper data and show that some of the trends in the topics are consistent with common understanding.
23 citations
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TL;DR: It is shown that useful predictors can be learned under powerful differential privacy guarantees, and even from moderately-sized data sets, by demonstrating significant improvements in the accuracy of private drug sensitivity prediction with a new robust private regression method.
Abstract: Users of a personalised recommendation system face a dilemma: recommendations can be improved by learning from data, but only if other users are willing to share their private information. Good personalised predictions are vitally important in precision medicine, but genomic information on which the predictions are based is also particularly sensitive, as it directly identifies the patients and hence cannot easily be anonymised. Differential privacy has emerged as a potentially promising solution: privacy is considered sufficient if presence of individual patients cannot be distinguished. However, differentially private learning with current methods does not improve predictions with feasible data sizes and dimensionalities. We show that useful predictors can be learned under powerful differential privacy guarantees, and even from moderately-sized data sets, by demonstrating significant improvements in the accuracy of private drug sensitivity prediction with a new robust private regression method. Our method matches the predictive accuracy of the state-of-the-art non-private lasso regression using only 4x more samples under relatively strong differential privacy guarantees. Good performance with limited data is achieved by limiting the sharing of private information by decreasing the dimensionality and by projecting outliers to fit tighter bounds, therefore needing to add less noise for equal privacy. The proposed differentially private regression method combines theoretical appeal and asymptotic efficiency with good prediction accuracy even with moderate-sized data. As already the simple-to-implement method shows promise on the challenging genomic data, we anticipate rapid progress towards practical applications in many fields. This article was reviewed by Zoltan Gaspari and David Kreil.
23 citations
Authors
Showing all 632 results
Name | H-index | Papers | Citations |
---|---|---|---|
Dimitri P. Bertsekas | 94 | 332 | 85939 |
Olli Kallioniemi | 90 | 353 | 42021 |
Heikki Mannila | 72 | 295 | 26500 |
Jukka Corander | 66 | 411 | 17220 |
Jaakko Kangasjärvi | 62 | 146 | 17096 |
Aapo Hyvärinen | 61 | 301 | 44146 |
Samuel Kaski | 58 | 522 | 14180 |
Nadarajah Asokan | 58 | 327 | 11947 |
Aristides Gionis | 58 | 292 | 19300 |
Hannu Toivonen | 56 | 192 | 19316 |
Nicola Zamboni | 53 | 128 | 11397 |
Jorma Rissanen | 52 | 151 | 22720 |
Tero Aittokallio | 52 | 271 | 8689 |
Juha Veijola | 52 | 261 | 19588 |
Juho Hamari | 51 | 176 | 16631 |