Henan Normal University

About: Henan Normal University is a education organization based out in Xinxiang, China. It is known for research contribution in the topics: Catalysis & Ionic liquid. The organization has 10863 authors who have published 11077 publications receiving 166773 citations.

Monitoring the Fluctuation of Hydrogen Peroxide in Diabetes and Its Complications with a Novel Near-Infrared Fluorescent Probe

Abstract: Diabetes is one of the metabolic diseases marked by hyperglycemia and is often accompanied by the occurrence of some complications. As a biomarker of oxidative stress, hydrogen peroxide (H2O2) has close association with the occurrence and development of diabetes and its complications. Unfortunately, there is no fluorescent probe reported for imaging H2O2 in diabetic mice. Here, a novel near-infrared (NIR) fluorescent probe named QX-B was designed and synthesized to detect H2O2. For the probe, the quinolinium-xanthene dye is used as the fluorophore and borate ester is chosen as the response group. After the addition of H2O2, a strong NIR fluorescence signal at 772 nm is observed. The probe not only shows high sensitivity with 10-fold enhancement but also displays excellent selectivity to H2O2 over other possible interfering species. In the meantime, the possible response mechanism of QX-B toward H2O2 was proposed and verified by the high-performance liquid chromatography (HPLC) experiment, mass spectra (MS) experiment, and density functional theory (DFT) calculation. Furthermore, based on the low cell cytotoxicity of QX-B, it has been applied in imaging exogenous and endogenous H2O2 in HeLa cells, HCT116 cells, 4T1 cells, and zebrafish successfully. More importantly, inspired by the performance of NIR fluorescence, QX-B has been used in monitoring H2O2 in diabetic mice for the first time. This provides very important information for the diagnosis and treatment of diabetes and its complications.

Hierarchical Porous Double-Shelled Electrocatalyst with Tailored Lattice Alkalinity toward Bifunctional Oxygen Reactions for Metal–Air Batteries

Abstract: Increasing both catalytic site accessibility and intrinsic activity of multishelled materials is critical to boost its efficiency for bifunctional oxygen electrocatalysis and initiate its application in metal–air batteries. Herein, a hierarchical porous double-shelled (Mg,Co)3O4 electrocatalyst with controllable Mg substitution is synthesized via a proposed in situ coordinating process. The hierarchical porosity optimizes the availability of active sites and broadens diffusion channels for oxygen species. Meanwhile, Mg substitution greatly increases electrical conductivity and realizes novel insight of tailoring lattice alkalinity. Specifically, Mg substitution positively influences oxygen electrocatalysis by inducing lattice buffer zones that promote hydroxyl detachment from nearby catalytic sites. As a result, the final hybrid of (Mg,Co)3O4 encapsulated in N-doped graphitized carbon affords superior bifunctional oxygen electrocatalytic activities, outperforming state-of-the-art noble-metal benchmarks. W...