Heritage Institute of Technology

About: Heritage Institute of Technology is a based out in . It is known for research contribution in the topics: Support vector machine & Transconductance. The organization has 581 authors who have published 1045 publications receiving 8345 citations.

Biomarker identification using next generation sequencing data of RNA

Abstract: Over the years, numerous studies have been performed in order to identify messenger RNAs (mRNAs) that are differentially expressed at different biological conditions for various diseases including cancer. In this regard, getting complete and noiseless data were always very challenging in previous technological set-up. While the inception of Next-Generation Sequencing (NGS) technology revolutionized the genome research, especially in the field of mRNA expression profile analysis. Here such data of breast cancer is used from The Cancer Genome Atlas (TCGA) to identify the cancer biomarkers. For this purpose, data have been preprocessed using statistical test and fold change concepts so that significant number of differentially expressed up and down regulated mRNAs can be recognized. Thereafter, wrapper based feature selection approach using Particle Swarm Optimization (PSO) and Support Vector Machine (SVM) has been applied on such preprocessed dataset to identify the potential mRNAs as biomarkers. Identified top 10 biomarkers are COMP, LRRC15, CTHRC1, CILP2, FOXF1, FIGF, PRDM16, LMX1B, IRX5 and LEPREL1. The quantitative results of the proposed method have been demonstrated in comparison with other state-of-the-art methods. Finally, enrichment analysis and the KEGG pathway analysis have also been conducted for the selected mRNAs.

Evaluating the anti-microbial effect of eugenol extracted from ocimum sanctum

Abstract: Eugenol is a phytochemical present in herbal and medicinal plants. It possess anti tubercular, anti-inflammatory, anti-mutagenic properties. Commercial or synthesised eugenol is used extensively in the market nowadays. The aim is to evaluate the anti-microbial property of eugenol extracted from both the powder and leaf samples of Ocimum sanctum (tulsi) and to have a comparative analysis of the synthetic eugenol and the naturally extracted eugenol from tulsi leaves. The eugenol is extracted from tulsi leaves by steam distillation. For quantitative analysis of the natural eugenol, HPLC and UV Spectroscopy are performed with commercial eugenol as the reference. While Raman Spectroscopy is performed for qualitative analysis of the constituents of tulsi leaves. Membrane casting is done with eugenol as the core ingredient and porosity of the membrane is checked by SEM. Further microbial assay is performed to evaluate the effect of eugenol. From the results it can be concluded that the eugenol extracted from the powder and fresh leaves of tulsi has anti-microbial effect and the membrane composed of eugenol has the capability to retain the eugenol. Keywords: Ocimum sanctum, eugenol, anti-microbial, membrane,anti-microbial.

Fisher information: quantum uncertainty relation

Abstract: The paper deals with the reformulation of quantum uncertainty relation involving position and momentum of a particle on the basis of the Kerridge measure of inaccuracy and the Fisher information.

Optimal Blending of PbSe and CdSe in Polycrystalline PbCdSe Nanocomposite Film: Improved Carrier Multiplication and Enhanced Photoconversion Efficiency.

Abstract: The present work reports galvanostatic electro-co-deposition of n-PbCdSe semiconductor (SC) films on FTO substrate from the respective precursors. Self-designed matrices were formulated at variable...