Heritage Institute of Technology

About: Heritage Institute of Technology is a based out in . It is known for research contribution in the topics: Support vector machine & Transconductance. The organization has 581 authors who have published 1045 publications receiving 8345 citations.

Wireless Sensor Networks and Its Routing Protocols: A Comparative Study

Abstract: Wireless sensor networks with hundreds to thousands of sensor nodes can collect information from an un attendant environment and transmit the collected information to a specific user depending on user end application. These sensor nodes have some constraints due to limited energy, storage capacity and computing power. Data sre routed from one node to another using different routing protocols. There are a number of routing protocols for wireless sensor network. In this review article, we discuss the architecture of the wireless sensor network. Further, we categorize the routing protocols according to some factors and summarize on their mode of operation. At the end, we put up a comparative study on these protocols.

Characterization of nimbidiol as a potent intestinal disaccharidase and glucoamylase inhibitor present in Azadirachta indica (neem) useful for the treatment of diabetes

Abstract: Azadirachta indica, used in antidiabetic herbal drugs, was reported to contain α-glucosidase inhibitor. Bioassay guided purification characterized the inhibitor as nimbidiol (a diterpenoid), present in root and stem-bark of the tree. Nimbidiol inhibited intestinal (mammalian) maltase-glucoamylase, sucrase-isomaltase, lactase, trehalase and fungal α-glucosidases. Nimbidiol showed a mixed competitive inhibition on intestinal carbohydrases. IC50, Ki and Ki' (µM) were 1.35 ± 0.12, 0.08 ± 0.01, 0.25 ± 0.11, respectively, for maltase-glucoamylase (maltotetraose as substrate). Nimbidiol was more potent inhibitor of isomaltase (IC50 0.85 ± 0.035 µM), lactase (IC50 20 ± 1.33 µM) and trehalase (IC50 30 ± 1.75 µM) than acarbose, voglibose, salacinol, kotalanol and mangiferin. Ki and Ki' values (µM) for intestinal sucrase were 0.7 ± 0.12 and 1.44 ± 0.65, respectively. Development of nimbidiol as an antidiabetic drug appears to be promising because of broad inhibition spectrum of intestinal glucosidases and easy synthesis of the molecule.