Institution
Hokkaido University
Education•Sapporo, Hokkaidô, Japan•
About: Hokkaido University is a education organization based out in Sapporo, Hokkaidô, Japan. It is known for research contribution in the topics: Population & Catalysis. The organization has 53925 authors who have published 115403 publications receiving 2651647 citations. The organization is also known as: Hokudai & Hokkaidō daigaku.
Topics: Population, Catalysis, Gene, Transplantation, Virus
Papers published on a yearly basis
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United States Department of Health and Human Services1, Ludwig Maximilian University of Munich2, University of Göttingen3, University of Bonn4, Charité5, Dokkyo Medical University6, University of Barcelona7, Karolinska University Hospital8, State University of Campinas9, Medical University of Graz10, University of California, San Diego11, Mayo Clinic12, Paris Diderot University13, McGill University Health Centre14, University of Queensland15, National Taiwan University16, University Hospital of Basel17, University of Adelaide18, Newcastle University19, Douglas Mental Health University Institute20, Poznan University of Medical Sciences21, Geneva College22, French Institute of Health and Medical Research23, University of New South Wales24, Neuroscience Research Australia25, Dalhousie University26, Johns Hopkins University27, Osaka University28, University of Lorraine29, Goethe University Frankfurt30, Hokkaido University31, Karolinska Institutet32, University of Gothenburg33, Veterans Health Administration34, University of Antioquia35, University of Calgary36, University of Cagliari37, Aarhus University38, University of Cincinnati39, University of Naples Federico II40, University of Salerno41, Nagoya University42, Harvard University43, Dresden University of Technology44, Montreal Neurological Institute and Hospital45, United States Department of Veterans Affairs46, National Institutes of Health47, Roy J. and Lucille A. Carver College of Medicine48, University of Iowa49, Heidelberg University50, University of Toronto51, RIKEN Brain Science Institute52
TL;DR: A genome-wide association study of lithium response in 2,563 patients collected by 22 participating sites from the International Consortium on Lithium Genetics (ConLiGen); the largest attempted so far finds a single locus of four linked SNPs on chromosome 21 met genome- wide significance criteria for association with lithium response.
258 citations
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TL;DR: In this article, a ring-opening polymerization of δ-valerolactone and e-caprolactone (e-CL) using 3-phenyl-1-propanol (PPA) as initiator and diphenyl phosphate (DPP) as the catalyst in toluene at room temperature with the [δ-VL or e-CL] 0/[PPA]0/[DPP] ratio of 50/1/1 homogeneously proceeded to afford poly(α-βαβββ ββ
Abstract: The ring-opening polymerization of δ-valerolactone (δ-VL) and e-caprolactone (e-CL) using 3-phenyl-1-propanol (PPA) as the initiator and diphenyl phosphate (DPP) as the catalyst in toluene at room temperature with the [δ-VL or e-CL]0/[PPA]0/[DPP] ratio of 50/1/1 homogeneously proceeded to afford poly(δ-valerolactone) (PVL) and poly(e-caprolactone) (PCL) with narrow polydispersity indices. The molecular weights determined from a 1H NMR analysis (PVL, Mn,NMR = 5170 g mol−1 and PCL, Mn,NMR = 5920 g mol−1) showed good agreement with those estimated from the initial ratio of [δ-VL or e-CL]0/[PPA]0 and monomer conversions (PVL, Mn,theo = 4890 g mol−1 and PCL, Mn,theo = 5680 g mol−1). The 1H NMR, SEC, and MALDI-TOF MS measurements of the obtained PVL and PCL clearly indicated the presence of the initiator residue at the chain end, confirming that the DPP-catalyzed ROP of lactones proceeded through an activated monomer mechanism. The kinetic and chain extension experiments confirmed the controlled/living nature f...
258 citations
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TL;DR: The muscarinic system can influence hippocampal functions by controlling different subsets of inhibitory synapses through the two distinct mechanisms, namely a cannabinoid‐dependent and cannabinoid‐independent mechanism.
Abstract: The cholinergic system in the CNS plays important roles in higher brain functions, primarily through muscarinic acetylcholine receptors. At cellular levels, muscarinic activation produces various effects including modulation of synaptic transmission. Here we report that muscarinic activation suppresses hippocampal inhibitory transmission through two distinct mechanisms, namely a cannabinoid-dependent and cannabinoid-independent mechanism. We made paired whole-cell recordings from cultured hippocampal neurons of rats and mice, and monitored inhibitory postsynaptic currents (IPSCs). When cannabinoid receptor type 1 (CB1) was blocked, oxotremorine M (oxo-M), a muscarinic agonist, suppressed IPSCs in a subset of neuron pairs. This suppression was associated with an increase in paired-pulse ratio, blocked by the M(2)-preferring antagonist gallamine, and was totally absent in neuron pairs from M(2)-knockout mice. When CB1 receptors were not blocked, oxo-M suppressed IPSCs in a gallamine-resistant manner in cannabinoid-sensitive pairs. This suppression was associated with an increase in paired-pulse ratio, blocked by the CB1 antagonist AM281, and was completely eliminated in neuron pairs from M(1)/M(3)-compound-knockout mice. Our immunohistochemical examination showed that M(2) and CB1 receptors were present at inhibitory presynaptic terminals of mostly different origins. These results indicate that two distinct mechanisms mediate the muscarinic suppression. In a subset of synapses, activation of M(2) receptors at presynaptic terminals suppresses GABA release directly. In contrast, in a different subset of synapses, activation of M(1)/M(3) receptors causes endocannabinoid production and subsequent suppression of GABA release by activating presynaptic CB1 receptors. Thus, the muscarinic system can influence hippocampal functions by controlling different subsets of inhibitory synapses through the two distinct mechanisms.
258 citations
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TL;DR: New methods for retrieving tropospheric ozone column depth and absorbing aerosol from the Earth Probe-Total Ozone Mapping Spectrometer (EP/TOMS) are used to follow pollution and to determine interannual variability and trends.
Abstract: New methods for retrieving tropospheric ozone column depth and absorbing aerosol (smoke and dust) from the Earth Probe–Total Ozone Mapping Spectrometer (EP/TOMS) are used to follow pollution and to determine interannual variability and trends. During intense fires over Indonesia (August to November 1997), ozone plumes, decoupled from the smoke below, extended as far as India. This ozone overlay a regional ozone increase triggered by atmospheric responses to the El Nino and Indian Ocean Dipole. Tropospheric ozone and smoke aerosol measurements from the Nimbus 7 TOMS instrument show El Nino signals but no tropospheric ozone trend in the 1980s. Offsets between smoke and ozone seasonal maxima point to multiple factors determining tropical tropospheric ozone variability.
258 citations
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TL;DR: Members of the highly diverse Miscellaneous Crenarchaeotal Group (MCG) are globally distributed in various marine and continental habitats and their high diversity and widespread distribution in subsurface sediments indicates that this group is globally important in sedimentary processes.
Abstract: Members of the highly diverse Miscellaneous Crenarchaeotal Group (MCG) are globally distributed in various marine and continental habitats In this study, we applied a polyphasic approach (rRNA slot blot hybridization, quantitative PCR (qPCR) and catalyzed reporter deposition FISH) using newly developed probes and primers for the in situ detection and quantification of MCG crenarchaeota in diverse types of marine sediments and microbial mats In general, abundance of MCG (cocci, 04 μm) relative to other archaea was highest (12–100%) in anoxic, low-energy environments characterized by deeper sulfate depletion and lower microbial respiration rates (P=006 for slot blot and P=005 for qPCR) When studied in high depth resolution in the White Oak River estuary and Hydrate Ridge methane seeps, changes in MCG abundance relative to total archaea and MCG phylogenetic composition did not correlate with changes in sulfate reduction or methane oxidation with depth In addition, MCG abundance did not vary significantly (P>01) between seep sites (with high rates of methanotrophy) and non-seep sites (with low rates of methanotrophy) This suggests that MCG are likely not methanotrophs MCG crenarchaeota are highly diverse and contain 17 subgroups, with a range of intragroup similarity of 82 to 94% This high diversity and widespread distribution in subsurface sediments indicates that this group is globally important in sedimentary processes
258 citations
Authors
Showing all 54156 results
Name | H-index | Papers | Citations |
---|---|---|---|
Shizuo Akira | 261 | 1308 | 320561 |
Yi Cui | 220 | 1015 | 199725 |
John F. Hartwig | 145 | 714 | 66472 |
Yoshihiro Kawaoka | 139 | 883 | 75087 |
David Y. Graham | 138 | 1047 | 80886 |
Takashi Kadowaki | 137 | 873 | 89729 |
Kazunari Domen | 130 | 908 | 77964 |
Susumu Kitagawa | 125 | 809 | 69594 |
Toshikazu Nakamura | 121 | 732 | 51374 |
Toshio Hirano | 120 | 401 | 55721 |
Li-Jun Wan | 113 | 639 | 52128 |
Wenbin Lin | 113 | 474 | 56786 |
Xiaoming Li | 113 | 1932 | 72445 |
Jinhua Ye | 112 | 658 | 49496 |
Terence Tao | 111 | 606 | 94316 |