Institution
Hokkaido University
Education•Sapporo, Hokkaidô, Japan•
About: Hokkaido University is a education organization based out in Sapporo, Hokkaidô, Japan. It is known for research contribution in the topics: Population & Catalysis. The organization has 53925 authors who have published 115403 publications receiving 2651647 citations. The organization is also known as: Hokudai & Hokkaidō daigaku.
Topics: Population, Catalysis, Gene, Transplantation, Virus
Papers published on a yearly basis
Papers
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TL;DR: Structural studies have uncovered the conserved specific interactions between autophagic receptors and Atg8‐family proteins through WXXL‐like sequences, which are termed the Atg 8‐family interacting motif (AIM) and may link the target–receptor complex to Autophagic membranes and/or their forming machineries.
472 citations
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Ludwig Maximilian University of Munich1, University of Cambridge2, University of Hyderabad3, Katholieke Universiteit Leuven4, Massachusetts Institute of Technology5, University of Antwerp6, Indian Institute of Science7, Yantai University8, University of Vigo9, King Abdullah University of Science and Technology10, Nanjing University of Science and Technology11, Lawrence Berkeley National Laboratory12, University of California, Berkeley13, Nanyang Technological University14, Soochow University (Suzhou)15, Technische Universität München16, ETH Zurich17, Lund University18, Hokkaido University19, Chinese Academy of Sciences20, University of California, Santa Cruz21, Beijing Institute of Technology22, City University of Hong Kong23, University of Texas at Austin24, Indian Association for the Cultivation of Science25, San Diego State University26, University of Washington27, Texas A&M University28, Bilkent University29, James I University30, Max Planck Society31, National Renewable Energy Laboratory32, University of Valencia33, Shanghai Jiao Tong University34, Istituto Italiano di Tecnologia35, Swiss Federal Laboratories for Materials Science and Technology36, University of Notre Dame37, Monash University, Clayton campus38, Imperial College London39
TL;DR: A comprehensive review of metal-halide perovskite nanocrystals can be found in this article, where researchers having expertise in different fields (chemistry, physics, and device engineering) have joined together to provide a state-of-the-art overview and future prospects of metalhalide nanocrystal research.
Abstract: Metal-halide perovskites have rapidly emerged as one of the most promising materials of the 21st century, with many exciting properties and great potential for a broad range of applications, from photovoltaics to optoelectronics and photocatalysis. The ease with which metal-halide perovskites can be synthesized in the form of brightly luminescent colloidal nanocrystals, as well as their tunable and intriguing optical and electronic properties, has attracted researchers from different disciplines of science and technology. In the last few years, there has been a significant progress in the shape-controlled synthesis of perovskite nanocrystals and understanding of their properties and applications. In this comprehensive review, researchers having expertise in different fields (chemistry, physics, and device engineering) of metal-halide perovskite nanocrystals have joined together to provide a state of the art overview and future prospects of metal-halide perovskite nanocrystal research.
471 citations
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TL;DR: The findings provide evidence for an association between levels of a biomarker, osteopontin, and ovarian cancer and suggest that future research assessing its clinical usefulness would be worthwhile.
Abstract: ContextDevelopment of new biomarkers for ovarian cancer is needed for early
detection and disease monitoring. Analyses involving complementary DNA (cDNA)
microarray data can be used to identify up-regulated genes in cancer cells,
whose products may then be further validated as potential biomarkers.ObjectiveTo describe validation studies of an up-regulated gene known as osteopontin,
previously identified using a cDNA microarray system.Design, Setting, and ParticipantsExperimental and cross-sectional studies were conducted involving ovarian
cancer and healthy human ovarian surface epithelial cell lines and cultures,
archival paraffin-embedded ovarian tissue collected between June 1992 and
June 2001, and fresh tissue and preoperative plasma from 144 patients evaluated
for a pelvic mass between June 1992 and June 2001 in gynecologic oncology
services at 2 US academic institutions. Plasma samples from 107 women selected
from an epidemiologic study of ovarian cancer initiated between May 1992 and
March 1997 were used as healthy controls.Main Outcome MeasuresRelative messenger RNA expression in cancer cells and fresh ovarian
tissue, measured by real-time polymerase chain reaction as 2−ΔΔCT(a quantitative value representing the amount of osteopontin expression);
osteopontin production, localized and scored in ovarian healthy and tumor
tissue with immunohistochemical studies; and amount of osteopontin in patient
vs control plasma, measured using an enzyme-linked immunoassay.ResultsThe geometric mean for 2−ΔΔCTfor osteopontin
expression in 5 healthy ovarian epithelial cell cultures was 4.1 compared
with 270.4 in 14 ovarian cancer cell lines (P = .03).
The geometric mean 2−ΔΔCTfor osteopontin expression
in tissue from 2 healthy ovarian epithelial samples was 9.0 compared with
164.0 in 27 microdissected ovarian tumor tissue samples (P = .06). Immunolocalization of osteopontin showed that tissue samples
from 61 patients with invasive ovarian cancer and 29 patients with borderline
ovarian tumors expressed higher levels of osteopontin than tissue samples
from 6 patients with benign tumors and samples of healthy ovarian epithelium
from 3 patients (P = .03). Osteopontin levels in
plasma were significantly higher (P<.001) in 51
patients with epithelial ovarian cancer (486.5 ng/mL) compared with those
of 107 healthy controls (147.1 ng/mL), 46 patients with benign ovarian disease
(254.4 ng/mL), and 47 patients with other gynecologic cancers (260.9 ng/mL).ConclusionsOur findings provide evidence for an association between levels of a
biomarker, osteopontin, and ovarian cancer and suggest that future research
assessing its clinical usefulness would be worthwhile.
471 citations
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TL;DR: It is proposed that different lamins are organized into separate, but interacting, microdomains and that LB1 is essential for their organization and the organization and regulation of chromatin are influenced by interconnections between these laminmicrodomains.
Abstract: The nuclear lamins function in the regulation of replication, transcription, and epigenetic modifications of chromatin. However, the mechanisms responsible for these lamin functions are poorly understood. We demonstrate that A- and B-type lamins form separate, but interacting, stable meshworks in the lamina and have different mobilities in the nucleoplasm as determined by fluorescence correlation spectroscopy (FCS). Silencing lamin B1 (LB1) expression dramatically increases the lamina meshwork size and the mobility of nucleoplasmic lamin A (LA). The changes in lamina mesh size are coupled to the formation of LA/C-rich nuclear envelope blebs deficient in LB2. Comparative genomic hybridization (CGH) analyses of microdissected blebs, fluorescence in situ hybridization (FISH), and immunofluorescence localization of modified histones demonstrate that gene-rich euchromatin associates with the LA/C blebs. Enrichment of hyperphosphorylated RNA polymerase II (Pol II) and histone marks for active transcription suggest that blebs are transcriptionally active. However, in vivo labeling of RNA indicates that transcription is decreased, suggesting that the LA/C-rich microenvironment induces promoter proximal stalling of Pol II. We propose that different lamins are organized into separate, but interacting, microdomains and that LB1 is essential for their organization. Our evidence suggests that the organization and regulation of chromatin are influenced by interconnections between these lamin microdomains.
471 citations
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TL;DR: In the case of the Tat, FHV, and octaarginine peptides, N-terminal stearylation of the peptides increases the transfection efficiency by approximately 100 times to reach the same order of magnitude as that of LipofectAMINE, one of the most efficient commercially available transfections agents.
470 citations
Authors
Showing all 54156 results
Name | H-index | Papers | Citations |
---|---|---|---|
Shizuo Akira | 261 | 1308 | 320561 |
Yi Cui | 220 | 1015 | 199725 |
John F. Hartwig | 145 | 714 | 66472 |
Yoshihiro Kawaoka | 139 | 883 | 75087 |
David Y. Graham | 138 | 1047 | 80886 |
Takashi Kadowaki | 137 | 873 | 89729 |
Kazunari Domen | 130 | 908 | 77964 |
Susumu Kitagawa | 125 | 809 | 69594 |
Toshikazu Nakamura | 121 | 732 | 51374 |
Toshio Hirano | 120 | 401 | 55721 |
Li-Jun Wan | 113 | 639 | 52128 |
Wenbin Lin | 113 | 474 | 56786 |
Xiaoming Li | 113 | 1932 | 72445 |
Jinhua Ye | 112 | 658 | 49496 |
Terence Tao | 111 | 606 | 94316 |