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Institution

Hokkaido University

EducationSapporo, Hokkaidô, Japan
About: Hokkaido University is a education organization based out in Sapporo, Hokkaidô, Japan. It is known for research contribution in the topics: Population & Catalysis. The organization has 53925 authors who have published 115403 publications receiving 2651647 citations. The organization is also known as: Hokudai & Hokkaidō daigaku.
Topics: Population, Catalysis, Gene, Transplantation, Virus


Papers
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Journal ArticleDOI
TL;DR: A pair of thick birefringent retarders is incorporated into the spectroscopic polarimeter, so the generated channeled spectrum is composed of three quasi-cosinusoidal components carrying the information about the SOP of the light that is being measured.
Abstract: We describe a novel method for the spectroscopic measurement of the state of polarization (SOP) of light. A pair of thick birefringent retarders is incorporated into the spectroscopic polarimeter, so the generated channeled spectrum is composed of three quasi-cosinusoidal components carrying the information about the SOP of the light that is being measured. Fourier inversion of the channeled spectrum provides significant parameters for determination of the spectrally resolved Stokes parameters of light. No mechanically movable components for polarization control or active devices for polarization modulation are used, and all the Stokes parameters can be determined at once from only the single spectrum. The effectiveness of this method is demonstrated by the generation of elliptically polarized light whose SOP varies with wave number.

397 citations

Journal ArticleDOI
TL;DR: In this article, a porosity model based on N-body simulations of aggregate collisions is applied to study the porosity change upon collision for a wide range of impact energies. But the authors neglect collisional fragmentation and instead focus on dust evolution outside the snow line, where the fragmentation has been suggested to be less significant than inside the snowline because of the high sticking efficiency of icy particles.
Abstract: Rapid orbital drift of macroscopic dust particles is one of the major obstacles to planetesimal formation in protoplanetary disks. We re-examine this problem by considering the porosity evolution of dust aggregates. We apply a porosity model based on recent N-body simulations of aggregate collisions, which allows us to study the porosity change upon collision for a wide range of impact energies. As a first step, we neglect collisional fragmentation and instead focus on dust evolution outside the snow line, where the fragmentation has been suggested to be less significant than inside the snow line because of the high sticking efficiency of icy particles. We show that dust particles can evolve into highly porous aggregates (with internal densities of much less than 0.1 g cm–3) even if collisional compression is taken into account. We also show that the high porosity triggers significant acceleration in collisional growth. This acceleration is a natural consequence of the particles' aerodynamical properties at low Knudsen numbers, i.e., at particle radii larger than the mean free path of the gas molecules. Thanks to this rapid growth, the highly porous aggregates are found to overcome the radial drift barrier at orbital radii less than 10 AU (assuming the minimum-mass solar nebula model). This suggests that, if collisional fragmentation is truly insignificant, formation of icy planetesimals is possible via direct collisional growth of submicron-sized icy particles.

397 citations

Journal ArticleDOI
TL;DR: This report describes the study design and profile of BBJ participants who were registered during the first 5-year period of the project, and concludes that the BBJ Project has constructed the infrastructure for genomic research for various common diseases.

397 citations

Journal ArticleDOI
TL;DR: It is demonstrated that a chlorophyll a oxygenase is involved inchlorophyll b formation and that an overlapping region of a nuclear genome was deleted in all mutants and that this encodes a protein whose sequence is similar to those of methyl monooxygenases.
Abstract: Chlorophyll b is an ubiquitous accessory pigment in land plants, green algae, and prochlorophytes. Its biosynthesis plays a key role in the adaptation to various light environments. We isolated six chlorophyll b-less mutants by insertional mutagenesis by using the nitrate reductase or argininosuccinate lyase genes as tags and examined the rearrangement of mutant genomes. We found that an overlapping region of a nuclear genome was deleted in all mutants and that this encodes a protein whose sequence is similar to those of methyl monooxygenases. This coding sequence also contains putative binding domains for a [2Fe-2S] Rieske center and for a mononuclear iron. The results demonstrate that a chlorophyll a oxygenase is involved in chlorophyll b formation. The reaction mechanism of chlorophyll b formation is discussed.

396 citations

Journal ArticleDOI
TL;DR: The committee of the Japanese Society for Helicobacter Research has revised the guidelines for diagnosis and treatment of H. pylori infection in Japan, finding the relationship between H.pylori and gastric cancer has been demonstrated more clearly.
Abstract: Background: Over the past few years, the profile of Helicobacter pylori infection has changed in Japan. In particular, the relationship between H. pylori and gastric cancer has been demonstrated more clearly. Accordingly, the committee of the Japanese Society for Helicobacter Research has revised the guidelines for diagnosis and treatment of H. pylori infection in Japan. Materials and Methods: Four meetings of guidelines preparation committee were held from July 2007 to December 2008. In the new guidelines, recommendations for treatment have been classified into five grades according to the Minds Recommendation Grades, while the level of evidence has been classified into six grades. The Japanese national health insurance system was not taken into consideration when preparing these guidelines. Results: Helicobacter pylori eradication therapy achieved a Grade A recommendation, being useful for the treatment of gastric or duodenal ulcer, for the treatment and prevention of H. pylori-associated diseases such as gastric cancer, and for inhibiting the spread of H. pylori infection. Levels of evidence were determined for each disease associated with H. pylori infection. For the diagnosis of H. pylori infection, measurement of H. pylori antigen in the feces was added to the tests not requiring biopsy. One week of proton-pump inhibitor-based triple therapy (including amoxicillin and metronidazole) was recommended as second-line therapy after failure of first-line eradication therapy. Conclusion: The revised Japanese guidelines for H. pylori are based on scientific evidence and avoid the administrative restraints that applied to earlier versions.

396 citations


Authors

Showing all 54156 results

NameH-indexPapersCitations
Shizuo Akira2611308320561
Yi Cui2201015199725
John F. Hartwig14571466472
Yoshihiro Kawaoka13988375087
David Y. Graham138104780886
Takashi Kadowaki13787389729
Kazunari Domen13090877964
Susumu Kitagawa12580969594
Toshikazu Nakamura12173251374
Toshio Hirano12040155721
Li-Jun Wan11363952128
Wenbin Lin11347456786
Xiaoming Li113193272445
Jinhua Ye11265849496
Terence Tao11160694316
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023127
2022427
20214,743
20204,805
20194,363
20184,112