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Institution

Hong Kong Baptist University

EducationHong Kong, China
About: Hong Kong Baptist University is a education organization based out in Hong Kong, China. It is known for research contribution in the topics: Population & China. The organization has 7811 authors who have published 18919 publications receiving 555274 citations. The organization is also known as: Hong Kong Baptist College & HKBU.


Papers
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Journal ArticleDOI
TL;DR: This paper proposes to further advance the literature by developing a smoothly weighted estimator for the sample standard deviation that fully utilizes the sample size information and shows that the new estimator provides a more accurate estimate for normal data and also performs favorably for non-normal data.
Abstract: When reporting the results of clinical studies, some researchers may choose the five-number summary (including the sample median, the first and third quartiles, and the minimum and maximum values) rather than the sample mean and standard deviation (SD), particularly for skewed data For these studies, when included in a meta-analysis, it is often desired to convert the five-number summary back to the sample mean and SD For this purpose, several methods have been proposed in the recent literature and they are increasingly used nowadays In this article, we propose to further advance the literature by developing a smoothly weighted estimator for the sample SD that fully utilizes the sample size information For ease of implementation, we also derive an approximation formula for the optimal weight, as well as a shortcut formula for the sample SD Numerical results show that our new estimator provides a more accurate estimate for normal data and also performs favorably for non-normal data Together with the optimal sample mean estimator in Luo et al, our new methods have dramatically improved the existing methods for data transformation, and they are capable to serve as "rules of thumb" in meta-analysis for studies reported with the five-number summary Finally for practical use, an Excel spreadsheet and an online calculator are also provided for implementing our optimal estimators

146 citations

Journal ArticleDOI
TL;DR: In this paper, the feasibility of using sub-surface horizontal flow constructed wetlands to treat municipal wastewater in Hong Kong was investigated and two different hydraulic retention times and different types of treatments (with and without vegetation) were investigated.

146 citations

Journal ArticleDOI
TL;DR: A detailed understanding of the mechanism of action of Ssd is provided, as a novel autophagic inducer, which has the potential of being developed into an anti-cancer agent for targeting apoptosis-resistant cancer cells.
Abstract: Autophagy is an important cellular process that controls cells in a normal homeostatic state by recycling nutrients to maintain cellular energy levels for cell survival via the turnover of proteins and damaged organelles. However, persistent activation of autophagy can lead to excessive depletion of cellular organelles and essential proteins, leading to caspase-independent autophagic cell death. As such, inducing cell death through this autophagic mechanism could be an alternative approach to the treatment of cancers. Recently, we have identified a novel autophagic inducer, saikosaponin-d (Ssd), from a medicinal plant that induces autophagy in various types of cancer cells through the formation of autophagosomes as measured by GFP-LC3 puncta formation. By computational virtual docking analysis, biochemical assays and advanced live-cell imaging techniques, Ssd was shown to increase cytosolic calcium level via direct inhibition of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase pump, leading to autophagy induction through the activation of the Ca2+/calmodulin-dependent kinase kinase–AMP-activated protein kinase–mammalian target of rapamycin pathway. In addition, Ssd treatment causes the disruption of calcium homeostasis, which induces endoplasmic reticulum stress as well as the unfolded protein responses pathway. Ssd also proved to be a potent cytotoxic agent in apoptosis-defective or apoptosis-resistant mouse embryonic fibroblast cells, which either lack caspases 3, 7 or 8 or had the Bax-Bak double knockout. These results provide a detailed understanding of the mechanism of action of Ssd, as a novel autophagic inducer, which has the potential of being developed into an anti-cancer agent for targeting apoptosis-resistant cancer cells.

145 citations

Journal ArticleDOI
TL;DR: What service-quality attributes must Internet banks offer to induce consumers to switch to online transactions and keep using them to be able to justify charging for them.
Abstract: What service-quality attributes must Internet banks offer to induce consumers to switch to online transactions and keep using them?

145 citations

Journal ArticleDOI
TL;DR: Two classes of one-dimensional nonintegrable systems represented by the Fermi-Pasta-Ulam (FPU) model and the discrete straight phi(4) model are studied to seek a generic mechanism of energy transport on a microscopic level sustaining macroscopic behaviors.
Abstract: Two classes of one-dimensional nonintegrable systems represented by the Fermi-Pasta-Ulam (FPU) model and the discrete ${\ensuremath{\varphi}}^{4}$ model are studied to seek a generic mechanism of energy transport on a microscopic level sustaining macroscopic behaviors. The results enable us to understand why the class represented by the ${\ensuremath{\varphi}}^{4}$ model has a normal thermal conductivity and the class represented by the FPU model does not even though the temperature gradient can be established.

145 citations


Authors

Showing all 7946 results

NameH-indexPapersCitations
Weihong Tan14089267151
Bin Liu138218187085
Jun Lu135152699767
John P. Giesy114116262790
Qiang Yang112111771540
Ming Hung Wong10371039738
Wei Wang95354459660
Jianhua Zhang9241528085
Xiaojun Wu91108831687
Guibin Jiang8885034633
Shu Tao8763927304
Paul K.S. Lam8748525614
Cheng-Yong Su8758132322
Hai-Long Jiang8619830946
Baowen Li8347723080
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202346
2022246
20211,655
20201,479
20191,244
20181,093