Hong Kong Baptist University

About: Hong Kong Baptist University is a education organization based out in Hong Kong, China. It is known for research contribution in the topics: Population & China. The organization has 7811 authors who have published 18919 publications receiving 555274 citations. The organization is also known as: Hong Kong Baptist College & HKBU.

ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties

Abstract: Because undesirable pharmacokinetics and toxicity of candidate compounds are the main reasons for the failure of drug development, it has been widely recognized that absorption, distribution, metabolism, excretion and toxicity (ADMET) should be evaluated as early as possible. In silico ADMET evaluation models have been developed as an additional tool to assist medicinal chemists in the design and optimization of leads. Here, we announced the release of ADMETlab 2.0, a completely redesigned version of the widely used AMDETlab web server for the predictions of pharmacokinetics and toxicity properties of chemicals, of which the supported ADMET-related endpoints are approximately twice the number of the endpoints in the previous version, including 17 physicochemical properties, 13 medicinal chemistry properties, 23 ADME properties, 27 toxicity endpoints and 8 toxicophore rules (751 substructures). A multi-task graph attention framework was employed to develop the robust and accurate models in ADMETlab 2.0. The batch computation module was provided in response to numerous requests from users, and the representation of the results was further optimized. The ADMETlab 2.0 server is freely available, without registration, at https://admetmesh.scbdd.com/.

Global Matrix 3.0 Physical Activity Report Card Grades for Children and Youth: Results and Analysis From 49 Countries

Abstract: Background: Accumulating sufficient moderate to vigorous physical activity is recognized as a key determinant of physical, physiological, developmental, mental, cognitive, and social health among children and youth (aged 5–17 y). The Global Matrix 3.0ofReportCardgradesonphysicalactivitywasdevelopedtoachieveabetterunderstandingoftheglobalvariationinchildand youth physical activity and associated supports. Methods: Work groups from 49 countries followed harmonized procedures to develop their Report Cards by grading 10 common indicators using the best available data. The participating countries were divided into 3 categories using the United Nations’ human development index (HDI) classification (low or medium, high, and very high HDI). Results: A total of 490 grades, including 369 letter grades and 121 incomplete grades, were assigned by the 49 work groups. Overall, an average grade of “C−,”“D+,” and “C−” was obtained for the low and medium HDI countries, high HDI countries, and very high HDI countries, respectively. Conclusions: The present study provides rich new evidence showing that the situation regarding the physical activity of children and youth is a concern worldwide. Strategic public investments to implement effective interventions to increase physical activity opportunities are needed.

Functional metallophosphors for effective charge carrier injection/transport: New robust OLED materials with emerging applications

Abstract: Organic light-emitting diodes (OLEDs) show great promise of revolutionizing display technologies in the scientific community. One successful approach for improved device efficiency has been to maximize the electron-hole recombination using dopants that emit from the triplet excited state. In this context, heavy transition metal complexes have recently gained tremendous academic and industrial research interest for fabricating highly efficient phosphorescent OLEDs by taking advantage of the 1:3 exciton singlet/triplet ratio predicted by simple spin statistics. Traditional room-temperature phosphorescent dyes are monofunctional materials working only as light-emitting centres but other key issues including charge generation and transport remain to be addressed in the electroluminescence. This Feature Article highlights recent and current advances in developing new synthetic strategies for multifunctional organometallic phosphors, which integrate both luminescent and charge carrier injection/transport functions into the same molecules so that they perform most, if not all, of the necessary functional roles (viz. photoexcitation, charge injection and transport as well as recombination) for achieving high-efficiency devices. Considerable focus is placed on the design concepts towards the tuning capability of charge-transport characteristics and phosphorescence emission colour of this prominent class of metallophosphors. In particular, the latest research endeavor in accomplishing novel triplet emitters with enhanced charge injection/charge transport of both hole and electron carriers is criticially discussed, which can provide good implications regarding their possible routes for future research development in the field.

Tunneling, Propping, and Expropriation: Evidence from Connected Party Transactions in Hong Kong

Abstract: We examine a sample of 328 filings of "connected transactions" between Hong Kong listed companies and their controlling shareholders during 1998-2000. We address three questions: What types of connected transactions are likely to lead to expropriation of minority shareholders? Which firms are more likely to expropriate? Does the market anticipate the expropriation? On average, firms earn significant negative excess returns both around the initial announcement of the connected transactions (from -2.5 per cent for firms making cash payments to directors to -5.9 per cent for firms selling equity stakes to their controlling shareholders) and during the 12-month period following the announcement (from -7.2 per cent for firms acquiring assets from their substantial shareholders to -21.9 per cent for firms selling assets to them). Excess returns are significantly negatively related to percentage ownership by the controlling shareholder. They are also significantly negatively related to proxies for information disclosure. The likelihood of undertaking connected transactions is higher for firms whose ultimate owners can be traced to mainland China. Finally, we find limited evidence that the market anticipates the expropriation by discounting firms that undertake connected transactions.