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Institution

Hong Kong Baptist University

EducationHong Kong, China
About: Hong Kong Baptist University is a education organization based out in Hong Kong, China. It is known for research contribution in the topics: Population & China. The organization has 7811 authors who have published 18919 publications receiving 555274 citations. The organization is also known as: Hong Kong Baptist College & HKBU.


Papers
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Journal ArticleDOI
TL;DR: Copper, Pb and Zn in the non-residual fractions noticeably increased in the contaminated sediments compared to those in the uncontaminated sediments, indicating a genuine concern is associated with potential transport of the contaminated Sediments downstream and enhanced solubility and mobility of trace metals in theNon-resIDual fractions.

307 citations

Journal ArticleDOI
TL;DR: In this article, the authors report the recent developments of heterogeneous catalysts for the synthesis of cyclic and dimethyl carbonates from CO 2 through various routes, including metal oxides, zeolites, smectite, supported organic bases, metal complexes, and ionic liquids.
Abstract: In this review article, we report the recent developments of heterogeneous catalysts for the synthesis of cyclic and dimethyl carbonates from CO 2 through various routes. The synthesis of cyclic carbonates via cycloaddition of CO 2 to epoxides is one of the few processes that have been commercialized. Compared to the many effective homogeneous catalysts, the heterogeneous catalysts have the advantages of being superior in stability and reusability. However, of the reported catalysts including metal oxides, zeolites, smectite, supported organic bases, metal complexes, and ionic liquids, none can be considered as highly active and selective under mild conditions. Also, heterogeneous catalysts used in other routes do not perform satisfactorily. The supported ionic liquids have attracted much more attention and are worthy of further research for the cycloaddition reaction. We predict that the mechanisms of acid–base or electrophile–nucleophile catalysis proposed in the literature will be valuable for the design and fabrication of high-performance catalysts.

305 citations

Journal ArticleDOI
TL;DR: DFT calculations indicate that the enantioselectivity originates from the CH/π attraction between the η(6)-arene ligand in the Ru-complex and the fused phenyl ring of dihydroquinoline via a 10-membered ring transition state with the participation of TfO(-) anion.
Abstract: Asymmetric hydrogenation of quinolines catalyzed by chiral cationic η6-arene–N-tosylethylenediamine–Ru(II) complexes have been investigated. A wide range of quinoline derivatives, including 2-alkylquinolines, 2-arylquinolines, and 2-functionalized and 2,3-disubstituted quinoline derivatives, were efficiently hydrogenated to give 1,2,3,4-tetrahydroquinolines with up to >99% ee and full conversions. This catalytic protocol is applicable to the gram-scale synthesis of some biologically active tetrahydroquinolines, such as (−)-angustureine, and 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline, a key intermediate for the preparation of the antibacterial agent (S)-flumequine. The catalytic pathway of this reaction has been investigated in detail using a combination of stoichiometric reaction, intermediate characterization, and isotope labeling patterns. The evidence obtained from these experiments revealed that quinoline is reduced via an ionic and cascade reaction pathway, including 1,4-hydride addition, isomeriz...

304 citations

Journal ArticleDOI
TL;DR: The present study explains the ambiguity about the effects of ginseng in vascular pathophysiology based on the existence of opposing active principles in the extract and proposes that Rg1 could be a prototype for a novel group of nonpeptide molecules that can induce therapeutic angiogenesis, such as in wound healing.
Abstract: Background-Ginseng is a commonly used nutraceutical. Intriguingly, existing literature reports both wound-healing and antitumor effects of ginseng extract through opposing activities on the vascular system. To elucidate this perplexity, we merged a chemical fingerprinting approach with a deconstructional study of the effects of pure molecules from ginseng extract on angiogenesis. Methods and Results-A mass spectrometric compositional analysis of American, Chinese and Korean, and Sanqi ginseng revealed distinct "sterol ginsenoside" fingerprints, especially in the ratio between a triol, Rg1, and a diol, Rb1, the 2 most prevalent constituents. Using a Matrigel implant model and reconstituting the extracts using distinct ratios of the 2 ginsenosides, we demonstrate that the dominance of Rg1 leads to angiogenesis, whereas Rb1 exerts an opposing effect. Rg1 also promoted functional neovascularization into a polymer scaffold in vivo and the proliferation of, chemoinvasion of, and tubulogenesis by endothelial cells in vitro, an effect mediated through the expression of nitric oxide synthase and the phosphatidylinositol-3 kinase→Akt pathway. In contrast, Rb1 inhibited the earliest step in angiogenesis, the chemoinvasion of endothelial cells. Conclusions-The present study explains, for the first time, the ambiguity about the effects of ginseng in vascular pathophysiology based on the existence of opposing active principles in the extract. We also unraveled a speciogeographic variation impinging on the compositional fingerprint that may modulate the final phenotype. This emphasizes the need for regulations standardizing herbal therapy, currently under the Dietary Supplement and Health Education Act. Furthermore, we propose that Rg1 could be a prototype for a novel group of nonpeptide molecules that can induce therapeutic angiogenesis, such as in wound healing. Chemicals / CAS: nitric oxide synthase, 125978-95-2; phosphatidylinositol 3 kinase, 115926-52-8; protein kinase B, 148640-14-6; 1-Phosphatidylinositol 3-Kinase, EC 2.7.1.137; Angiogenesis Inducing Agents; Angiogenesis Inhibitors; Drug Implants; Enzyme Inhibitors; ginsenoside Rb1; ginsenoside Rg1, 22427-39-0; Ginsenosides; NG-Nitroarginine Methyl Ester, 50903-99-6

303 citations


Authors

Showing all 7946 results

NameH-indexPapersCitations
Weihong Tan14089267151
Bin Liu138218187085
Jun Lu135152699767
John P. Giesy114116262790
Qiang Yang112111771540
Ming Hung Wong10371039738
Wei Wang95354459660
Jianhua Zhang9241528085
Xiaojun Wu91108831687
Guibin Jiang8885034633
Shu Tao8763927304
Paul K.S. Lam8748525614
Cheng-Yong Su8758132322
Hai-Long Jiang8619830946
Baowen Li8347723080
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202346
2022246
20211,655
20201,479
20191,244
20181,093