Institution
Hong Kong Baptist University
Education•Hong Kong, China•
About: Hong Kong Baptist University is a education organization based out in Hong Kong, China. It is known for research contribution in the topics: Population & China. The organization has 7811 authors who have published 18919 publications receiving 555274 citations. The organization is also known as: Hong Kong Baptist College & HKBU.
Topics: Population, China, Catalysis, Cluster analysis, Organic solar cell
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors argue and demonstrate empirically that success in implementing an ERP system and in gaining performance improvement should be conceptualised as two separate dependent variables, the former aspect is based upon project delivery outcomes, while the latter assesses post-ERP project performance.
234 citations
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TL;DR: PAH concentrations in the Guiyu soil were affected by the primitive E-waste recycling activities, which indicated that PAHs were mainly distributed into three groups in accordance with their ring numbers and biological and anthropogenic source.
234 citations
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TL;DR: More evidence-based research and chemical optimization of these compounds could further enhance the effectiveness of these plant-based medicines in angiotherapy.
233 citations
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TL;DR: This paper considers the linearly constrained separable convex programming, whose objective function is separable into m individual convex functions without coupled variables, and shows the global convergence of this extension when the involved functions are further assumed to be strongly convex.
Abstract: We consider the linearly constrained separable convex programming, whose objective function is separable into m individual convex functions without coupled variables. The alternating direction method of multipliers has been well studied in the literature for the special case m=2, while it remains open whether its convergence can be extended to the general case m≥3. This note shows the global convergence of this extension when the involved functions are further assumed to be strongly convex.
233 citations
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TL;DR: The results indicate that osteoblast-specific aptamer-functionalized LNPs could act as a new RNAi-based bone anabolic strategy, advancing the targeted delivery selectivity of osteogenic siRNAs from the tissue level to the cellular level.
Abstract: Currently, major concerns about the safety and efficacy of RNA interference (RNAi)-based bone anabolic strategies still exist because of the lack of direct osteoblast-specific delivery systems for osteogenic siRNAs. Here we screened the aptamer CH6 by cell-SELEX, specifically targeting both rat and human osteoblasts, and then we developed CH6 aptamer-functionalized lipid nanoparticles (LNPs) encapsulating osteogenic pleckstrin homology domain-containing family O member 1 (Plekho1) siRNA (CH6-LNPs-siRNA). Our results showed that CH6 facilitated in vitro osteoblast-selective uptake of Plekho1 siRNA, mainly via macropinocytosis, and boosted in vivo osteoblast-specific Plekho1 gene silencing, which promoted bone formation, improved bone microarchitecture, increased bone mass and enhanced mechanical properties in both osteopenic and healthy rodents. These results indicate that osteoblast-specific aptamer-functionalized LNPs could act as a new RNAi-based bone anabolic strategy, advancing the targeted delivery selectivity of osteogenic siRNAs from the tissue level to the cellular level.
232 citations
Authors
Showing all 7946 results
Name | H-index | Papers | Citations |
---|---|---|---|
Weihong Tan | 140 | 892 | 67151 |
Bin Liu | 138 | 2181 | 87085 |
Jun Lu | 135 | 1526 | 99767 |
John P. Giesy | 114 | 1162 | 62790 |
Qiang Yang | 112 | 1117 | 71540 |
Ming Hung Wong | 103 | 710 | 39738 |
Wei Wang | 95 | 3544 | 59660 |
Jianhua Zhang | 92 | 415 | 28085 |
Xiaojun Wu | 91 | 1088 | 31687 |
Guibin Jiang | 88 | 850 | 34633 |
Shu Tao | 87 | 639 | 27304 |
Paul K.S. Lam | 87 | 485 | 25614 |
Cheng-Yong Su | 87 | 581 | 32322 |
Hai-Long Jiang | 86 | 198 | 30946 |
Baowen Li | 83 | 477 | 23080 |