Hong Kong Polytechnic University

About: Hong Kong Polytechnic University is a education organization based out in Hong Kong, China. It is known for research contribution in the topics: Tourism & Population. The organization has 29633 authors who have published 72136 publications receiving 1956312 citations. The organization is also known as: HKPU & PolyU.

Muscle damage in mdx (dystrophic) mice: role of calcium and reactive oxygen species.

Abstract: 1. Duchenne muscular dystrophy (DMD) is a lethal, degenerative muscle disease caused by a genetic mutation that leads to the complete absence of the cytoskeletal protein dystrophin in muscle fibres. 2. The present review provides an overview of some of the physiological pathways that may contribute to muscle damage and degeneration in DMD, based primarily on experimental findings in the mdx mouse, an animal model of this disease. 3. A rise in intracellular calcium is widely thought to be an important initiating event in the dystrophic pathogenesis. The pathway(s) leading to increased intracellular calcium in dystrophin deficient muscle is uncertain, but recent work from our laboratory provides evidence that stretch-activated channels are an important source of the calcium influx. Other possible routes of calcium entry are also discussed. 4. The consequences of elevated cytosolic calcium may include activation of proteases, such as calpain, and increased production of reactive oxygen species (ROS), which can cause protein and membrane damage. 5. Another possible cause of damage in dystrophic muscle involves inflammatory pathways, such as those mediated by neutrophils, macrophages and associated cytokines. There is recent evidence that increased ROS may be important in both the activation of and the damage caused by this inflammatory pathway in mdx muscle.

Lower Bound Theory of Nonzero Entries in Solutions of $\ell_2$-$\ell_p$ Minimization

Abstract: Recently, variable selection and sparse reconstruction are solved by finding an optimal solution of a minimization model, where the objective function is the sum of a data-fitting term in $\ell_2$ norm and a regularization term in $\ell_p$ norm $(0

Major Barriers to Off-Site Construction: The Developer’s Perspective in China

Abstract: Off-site construction (OSC) has been regarded as an effective means of improving construction quality and efficiency. The adoption of OSC has been slower in developing countries such as China than in developed countries, and research on the barriers inhibiting the sector’s growth is inadequate. This paper aims to investigate the major factors inhibiting the adoption of OSC with reference to the Chinese construction market. Thirty factors influencing the use of OSC were identified through a literature review, questionnaire survey, and face-to-face interview with professionals in the construction industry. A questionnaire was sent out to developers in China, and 83 completed questionnaires were retrieved. Ranking analysis was used to identify 18 critical factors. The top three barriers are “absence of government regulations and incentives,” “high initial cost,” and “dependence on traditional construction methods.” Factor analysis enables grouping of the 18 critical factors into five categories, name...