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Institution

Hood College

EducationFrederick, Maryland, United States
About: Hood College is a education organization based out in Frederick, Maryland, United States. It is known for research contribution in the topics: Social work & Population. The organization has 325 authors who have published 463 publications receiving 10391 citations. The organization is also known as: Hood.
Topics: Social work, Population, Grief, Gene, Poison control


Papers
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Journal ArticleDOI
09 Oct 2008-Nature
TL;DR: The synteny and isochore structure of P. vivax chromosomes are described, and it is shown that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously.
Abstract: The human malaria parasite Plasmodium vivax is responsible for 25-40% of the approximately 515 million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe and incapacitating clinical symptoms and often causes relapses months after a primary infection has cleared. Despite its importance as a major human pathogen, P. vivax is little studied because it cannot be propagated continuously in the laboratory except in non-human primates. We sequenced the genome of P. vivax to shed light on its distinctive biological features, and as a means to drive development of new drugs and vaccines. Here we describe the synteny and isochore structure of P. vivax chromosomes, and show that the parasite resembles other malaria parasites in gene content and metabolic potential, but possesses novel gene families and potential alternative invasion pathways not recognized previously. Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species.

787 citations

Journal ArticleDOI
27 Nov 1992-Science
TL;DR: Nuclear microinjection of cells constitutively expressing SV40 large T antigen with either a 15-mer or 20-mer PNA targeted to the T Ag messenger RNA suppressed T Ag expression, and Binding of PNAs to RNA resulted in site-specific termination of both reverse transcription and in vitro translation.
Abstract: Peptide nucleic acids (PNAs) are polyamide oligomers that can strand invade duplex DNA, causing displacement of one DNA strand and formation of a D-loop. Binding of either a T10 PNA or a mixed sequence 15-mer PNA to the transcribed strand of a G-free transcription cassette caused 90 to 100 percent site-specific termination of pol II transcription elongation. When a T10 PNA was bound on the nontranscribed strand, site-specific inhibition never exceeded 50 percent. Binding of PNAs to RNA resulted in site-specific termination of both reverse transcription and in vitro translation, precisely at the position of the PNA.RNA heteroduplex. Nuclear microinjection of cells constitutively expressing SV40 large T antigen (T Ag) with either a 15-mer or 20-mer PNA targeted to the T Ag messenger RNA suppressed T Ag expression. This effect was specific in that there was no reduction in beta-galactosidase expression from a coinjected expression vector and no inhibition of T Ag expression after microinjection of a 10-mer PNA.

624 citations

Journal ArticleDOI
TL;DR: While human language skills transfer easily to human-chatbot communication, there are notable differences in the content and quality of such conversations.

509 citations

Journal ArticleDOI
Anita Jose1, Shang-Mei Lee1
TL;DR: The authors analyzed the content of corporate environmental disclosures with respect to the following seven areas: environmental planning considerations, top management support to the institutionalization of environmental concerns, environmental structures and organizing specifics, environmental leadership activities, environmental control, external validations or certifications of environmental programs, and forms of corporate Environmental disclosures.
Abstract: Today, more corporations disclose information about their environmental performance in response to stakeholder demands of environmental responsibility and accountability. What information do corporations disclose on their websites? This paper investigates the environmental management policies and practices of the 200 largest corporations in the world. Based on a content analysis of the environmental reports of Fortune’s Global 200 companies, this research analyzes the content of corporate environmental disclosures with respect to the following seven areas: environmental planning considerations, top management support to the institutionalization of environmental concerns, environmental structures and organizing specifics, environmental leadership activities, environmental control, external validations or certifications of environmental programs, and forms of corporate environmental disclosures.

479 citations

Journal ArticleDOI
TL;DR: The authors conducted a series of cross-country regression tests using four different corruption datasets and found that corruption slows growth and/or reduces investment in most developing countries, particularly small developing countries but increases growth in the large East Asian newly industrializing economies.

392 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20232
20226
202124
202022
201934
201829