Institution
Hospital for Sick Children
Healthcare•Toronto, Ontario, Canada•
About: Hospital for Sick Children is a healthcare organization based out in Toronto, Ontario, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 4097 authors who have published 3746 publications receiving 129066 citations. The organization is also known as: Sick Kids Hospital & SickKids.
Papers published on a yearly basis
Papers
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Verneri Anttila1, Verneri Anttila2, Brendan Bulik-Sullivan2, Brendan Bulik-Sullivan1 +717 more•Institutions (270)
TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
Abstract: Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.
1,357 citations
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TL;DR: This article found that impulsive people respond more slowly to signals to inhibit (stop signals) than non-impulsive people when they hear a stop signal, and that the delay between the go signal and the stop signal was determined by a tracking procedure designed to allow subjects to inhibit on 50% of the trials.
Abstract: We report an experiment testing the hypothesis that impulsive behavior reflects a deficit in the ability to inhibit prepotent responses Specifically, we examined whether impulsive people respond more slowly to signals to inhibit (stop signals) than non-impulsive people In this experiment, 136 undergraduate students completed an impulsivity questionnaire and then participated in a stop-signal experiment, in which they performed a choice reaction time (go) task and were asked to inhibit their responses to the go task when they heard a stop signal The delay between the go signal and the stop signal was determined by a tracking procedure designed to allow subjects to inhibit on 50% of the stop-signal trials Reaction time to the go signal did not vary with impulsivity, but estimated stop-signal reaction time was longer in more impulsive subjects, consistent with the hypothesis and consistent with results from populations with pathological problems with impulse control
1,350 citations
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James Bentham1, Mariachiara Di Cesare2, Mariachiara Di Cesare1, Gretchen A Stevens3 +787 more•Institutions (246)
TL;DR: The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
Abstract: Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3–19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8–144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
1,348 citations
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TL;DR: It is demonstrated that the DASH had validity and responsiveness in both proximal and distal disorders, confirming its usefulness across the whole extremity.
1,268 citations
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TL;DR: This largest longitudinal pediatric neuroimaging study reported to date demonstrates the importance of examining size-by-age trajectories of brain development rather than group averages across broad age ranges when assessing sexual dimorphism and finds robust male/female differences in the shapes of trajectories.
1,208 citations
Authors
Showing all 4166 results
Name | H-index | Papers | Citations |
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David L. Kaplan | 177 | 1944 | 146082 |
Zulfiqar A Bhutta | 165 | 1231 | 169329 |
Marco A. Marra | 153 | 620 | 184684 |
Janet Rossant | 138 | 416 | 71913 |
Stephen W. Scherer | 135 | 685 | 85752 |
Gideon Koren | 129 | 1994 | 81718 |
Lewis E. Kay | 120 | 452 | 51031 |
Sergio Grinstein | 118 | 533 | 51452 |
James M. Swanson | 117 | 415 | 47131 |
Edwin K. Silverman | 115 | 670 | 43901 |
Kevin C. Jones | 114 | 744 | 50207 |
Andrew W. Howard | 112 | 866 | 55716 |
David B. Dunger | 110 | 703 | 55784 |
Stefan M. Pfister | 109 | 567 | 54981 |
Gareth J. Morgan | 109 | 1019 | 52957 |