Hospital for Sick Children

About: Hospital for Sick Children is a healthcare organization based out in Toronto, Ontario, Canada. It is known for research contribution in the topics: Population & Medicine. The organization has 4097 authors who have published 3746 publications receiving 129066 citations. The organization is also known as: Sick Kids Hospital & SickKids.

Clinical Aspects of Urinary, Genital and Lower Bowel Anomalies and Ambiguous Genitalia

Abstract: This chapter endeavors to provide the necessary background in congenital anomalies of the urogenital system and lower bowel for the pelvic surgeon. Incorporated in this synopsis is a brief review of embryology, sexual development, and intersex disorders. Surgical principles in restoring anatomy are discussed.

Micronutrient Deficiencies: Impact on Therapeutic Outcomes

Abstract: Stemming from an interplay of socioeconomic disparity, poverty, chronic food insecurity, poor feeding practices, and illness, more than two billion individuals worldwide are chronically malnourished and suffer from micronutrient deficiencies. Malnutrition is directly or indirectly responsible for 45 % of global deaths among children under 5 years of age. In early childhood, chronic malnutrition resulting in micronutrient deficiencies may significantly impact motor and cognitive development. Micronutrient deficiencies which have a notably increased prevalence in children of developing countries are vitamin A, zinc, and iron. The authors provide an overview of the role of these essential nutrients in health and illness and discuss various strategies which have been studied and implemented in order to improve the nutritional status of children in the developing world.

Design of Peptide Molecules to Mimic the Metal Binding Sites of Proteins

Abstract: The molecular design to mimic the metal-binding site of a protein molecule entails abstracting the minimum requirements which must be retained in a molecule in order to maintain parameters controling the geometry, metal-binding ligands and microenvironment at the metal-binding site. A linear peptide may be designed to mimic a site which is located on a short linear amino acid sequence. However, when the metal-binding ligands originate from different parts of the polypeptide backbone, a cyclic peptide should be designed with amino acid residues having appropriate side chains. For the purpose of the design, building of suitable molecular models are essential. This can be supplemented by conformational calculations. Three examples are presented for the molecular design of the metal-binding sites: Copper(II)-transport site of human albumin, Zn(II)-binding sites of two metalloenzymes: carboxypeptidase and carbonic anhydrase.