Institution
Hospital General Universitario Gregorio Marañón
Healthcare•Madrid, Spain•
About: Hospital General Universitario Gregorio Marañón is a healthcare organization based out in Madrid, Spain. It is known for research contribution in the topics: Population & Transplantation. The organization has 11975 authors who have published 12386 publications receiving 244847 citations.
Topics: Population, Transplantation, Medicine, Myocardial infarction, Cancer
Papers published on a yearly basis
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TL;DR: During induced AF, SI shortening after either drift or acceleration of a source results in intermittent fibrillatory conduction and formation of fractionated electrograms at the PLAW.
106 citations
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TL;DR: One third of cancers developed by patients with primary SjS are B-cell lymphomas, which is also associated with the development of some non-hematological cancers (thyroid, oral cavity, and stomach).
Abstract: The purpose of this study is to characterize the risk of cancer in a large cohort of patients with primary Sjogren syndrome (SjS). We had analyzed the development of cancer in 1300 consecutive patients fulfilling the 2002 SjS classification criteria. The baseline clinical and immunological characteristics and systemic activity (ESSDAI scores) were assessed at diagnosis as predictors of cancer using Cox proportional hazards regression analysis adjusted for age at diagnosis and gender. The sex-and age-specific standardized incidence ratios (SIR) of cancer were estimated from 2012 Spanish mortality data. After a mean follow-up of 91 months, 127 (9.8%) patients developed 133 cancers. The most frequent type of cancer was B-cell lymphoma (including 27 MALT and 19 non-MALT B-cell lymphomas). Systemic activity at diagnosis of primary SjS correlated with the risk of hematological neoplasia and cryoglobulins with a high risk of either B-cell or non-B-cell lymphoma subtypes. Patients with cytopenias had a high risk of non-MALT B-cell and non-B-cell cancer, while those with low C3 levels had a high risk of MALT lymphomas and those with monoclonal gammopathy and low C4 levels had a high risk of non-MALT lymphomas. The estimated SIR for solid cancer was 1.13 and 11.02 for hematological cancer. SIRs for specific cancers were 36.17 for multiple myeloma and immunoproliferative diseases, 19.41 for Hodgkin lymphoma, 6.04 for other non-Hodgkin lymphomas, 5.17 for thyroid cancer, 4.81 for cancers of the lip and oral cavity, and 2.53 for stomach cancer. One third of cancers developed by patients with primary SjS are B-cell lymphomas. The prognostic factors identified at SjS diagnosis differed according to the subtype of B-cell lymphoma developed. Primary SjS is also associated with the development of some non-hematological cancers (thyroid, oral cavity, and stomach).
106 citations
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University of Pennsylvania1, University of Maryland, Baltimore2, Neuroscience Research Australia3, University of New South Wales4, State University of New York Upstate Medical University5, University of Marburg6, University of Newcastle7, University of Melbourne8, University of Queensland9, University of New Mexico10, National University of Singapore11, Nanyang Technological University12, Baylor College of Medicine13, International University Of Catalonia14, Casa Sollievo della Sofferenza15, University of Bari16, Goethe University Frankfurt17, University of Basel18, Stellenbosch University19, New Generation University College20, Seoul National University Hospital21, UPRRP College of Natural Sciences22, University of Münster23, Hospital General Universitario Gregorio Marañón24, Georgia State University25, Georgia Institute of Technology26, Dresden University of Technology27, Johns Hopkins University28, University of Toyama29, Montreal Neurological Institute and Hospital30, University of Zurich31, Charles University in Prague32, National Institutes of Health33, Czech Technical University in Prague34, Academy of Sciences of the Czech Republic35, Maastricht University36, University of Oxford37, University of California, Irvine38, University of Cape Town39, University of Antioquia40, University of Barcelona41, University of Southern California42, Boston Children's Hospital43, Harvard University44, Hartford Hospital45, Yale University46, Monash University47, Geneva College48
TL;DR: Whether the batch adjustment method, ComBat, can further reduce site-related heterogeneity and thus increase statistical power and recommend applying the ComBat function to attenuate potential effects of site in ENIGMA projects and other multi-site structural imaging work.
106 citations
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TL;DR: It is concluded that leg training accelerates the speed of re-oxygenation of the vastus lateralis muscle after exercise and is correlated to changes in the oxidative enzymes.
Abstract: We studied 21 patients with chronic obstructive pulmonary disease aged [mean (SD)] 63 (10) years, with a mean forced expiratory volume in 1 s of 40 (6)% and a peak oxygen uptake of 67 (11)% of predicted values. Patients trained for 6 weeks on a cycle ergometer at high work-rates (WR). Near-infrared spectroscopy was used to obtain the time-constant of the deoxygenation recovery signal (τHbO2) during three constant WR exercise tests, one below and two above the lactic acidosis threshold (θL). Glycolytic and oxidative enzymes and lactate concentrations were assessed in muscle biopsies. The τHbO2 decreased significantly in all three constant WR tests: –18 (24)s, –20 (23) s and –13 (22) s, respectively. Endurance time increased in the higher WR tests, by 5.7 (4.8) min and 3.6 (2.7) min, respectively. The activity of citrate-synthase (CS) and creatine-kinase changed significantly from 20 (10) to 30 (13) µmol·min–1·g–1 and from 3.825 (950) to 3.402 (526) µmol·min–1·g–1, respectively. Training also improved significantly the mean response time of the on-transient of oxygen uptake (τ'V˙O2) of the below-θL test. We found significant correlations between changes in CS and changes in τHbO2, τ'V˙O2 and endurance time. We conclude that leg training accelerates the speed of re-oxygenation of the vastus lateralis muscle after exercise. This improvement is correlated to changes in the oxidative enzymes.
105 citations
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TL;DR: Evaluated the safety and efficacy of six cycles of R‐CHOP in patients with HIV‐related DLBCL and to determine whether response to highly active antiretroviral therapy (HAART) had prognostic impact, IPI score and virological response to HAART were the prognostic parameters for response and survival.
Abstract: Immunochemotherapy with cyclophosphamide, adriamycin, vincristine, prednisone and rituximab (R-CHOP) is the standard treatment in non-immunosuppressed patients with diffuse large B-cell lymphoma (DLBCL), but its adequacy has not been definitively established in patients with human immunodeficiency virus (HIV)-related lymphoma. This phase II trial aimed to evaluate the safety and efficacy of six cycles of R-CHOP in patients with HIV-related DLBCL and to determine whether response to highly active antiretroviral therapy (HAART) had prognostic impact. Patients were eligible if they had performance status <3 and absence of active opportunistic infections. Eighty-one patients were enrolled, 57 in stages III or IV, International Prognostic Index (IPI) 0 or 1 (n = 26), 2 (n = 19), 3 (n = 20) and 4 or 5 (n = 16), and median CD4 lymphocyte count of 0.158 x 10(9)/l. The main adverse events were neutropenia (48% of cycles) and infections (10% of cycles), which were fatal in seven patients. Complete response was achieved in 55 (69%) patients, with an estimated 3-year disease-free survival of 77% and 3-year overall survival of 56%. IPI score and virological response to HAART were the prognostic parameters for response and survival. In HIV-related DLBCL R-CHOP is feasible, safe and effective. The prognosis depends on lymphoma-related parameters and on the response to HAART.
105 citations
Authors
Showing all 12014 results
Name | H-index | Papers | Citations |
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David H. Adams | 155 | 1613 | 117783 |
Stefanie Dimmeler | 147 | 574 | 81658 |
Stuart J. Pocock | 145 | 684 | 143547 |
M. I. Martínez | 134 | 1251 | 79885 |
Guy A. Rouleau | 129 | 884 | 65892 |
Jose L. Jimenez | 124 | 654 | 64226 |
Antoni Torres | 120 | 1238 | 65049 |
Paul P. Tak | 112 | 591 | 57689 |
Luis A. Diaz | 111 | 596 | 75036 |
Frans Van de Werf | 109 | 747 | 63537 |
José Luis Zamorano | 105 | 695 | 133396 |
Francisco Sánchez-Madrid | 102 | 527 | 43418 |
Francesco Locatelli | 99 | 820 | 42454 |
Roberto M. Lang | 96 | 823 | 56638 |
Carlos Simón | 95 | 589 | 31147 |