Institution
Hospital General Universitario Gregorio Marañón
Healthcare•Madrid, Spain•
About: Hospital General Universitario Gregorio Marañón is a healthcare organization based out in Madrid, Spain. It is known for research contribution in the topics: Population & Transplantation. The organization has 11975 authors who have published 12386 publications receiving 244847 citations.
Topics: Population, Transplantation, Medicine, Myocardial infarction, Cancer
Papers published on a yearly basis
Papers
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TL;DR: A gene mutation is described that modulates touch sensitivity in mice and humans and KCNQ4 is established as a specific molecular marker for rapidly adapting Meissner and a subset of hair follicle afferents.
Abstract: Mutations inactivating the potassium channel KCNQ4 (K(v)7.4) lead to deafness in humans and mice. In addition to its expression in mechanosensitive hair cells of the inner ear, KCNQ4 is found in the auditory pathway and in trigeminal nuclei that convey somatosensory information. We have now detected KCNQ4 in the peripheral nerve endings of cutaneous rapidly adapting hair follicle and Meissner corpuscle mechanoreceptors from mice and humans. Electrophysiological recordings from single afferents from Kcnq4(-/-) mice and mice carrying a KCNQ4 mutation found in DFNA2-type monogenic dominant human hearing loss showed elevated mechanosensitivity and altered frequency response of rapidly adapting, but not of slowly adapting nor of D-hair, mechanoreceptor neurons. Human subjects from independent DFNA2 pedigrees outperformed age-matched control subjects when tested for vibrotactile acuity at low frequencies. This work describes a gene mutation that modulates touch sensitivity in mice and humans and establishes KCNQ4 as a specific molecular marker for rapidly adapting Meissner and a subset of hair follicle afferents.
98 citations
TL;DR: The difficulties of prosthetic rehabilitation are discussed, along with the individualized solutions applied, the repercussions on the temporomandibular joint, and the management protocol adopted by the service.
97 citations
TL;DR: The findings confirm those from previous reports suggesting that bed rest has no influence on the risk of developing PE among patients with acute DVT of the lower limbs and show for the first time the lack of influence of bed rest even in patients presenting with acute submassive PE.
97 citations
TL;DR: This study shows that the introduction of a CRRT device into the ECMO circuit is a safe and effective technique that improves fluid balance, increases filter life, and does not cause complications.
96 citations
TL;DR: The high prevalence of anticardiolipin antibodies in patients with vaso-occlusive retinopathy exempt from conventional risk factors, and the relevant diagnostic and therapeutic implications, lead us to recommend a systematic search for specific antiphospholipid antibodies in such patients.
96 citations
Authors
Showing all 12014 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| David H. Adams | 155 | 1613 | 117783 |
| Stefanie Dimmeler | 147 | 574 | 81658 |
| Stuart J. Pocock | 145 | 684 | 143547 |
| M. I. Martínez | 134 | 1251 | 79885 |
| Guy A. Rouleau | 129 | 884 | 65892 |
| Jose L. Jimenez | 124 | 654 | 64226 |
| Antoni Torres | 120 | 1238 | 65049 |
| Paul P. Tak | 112 | 591 | 57689 |
| Luis A. Diaz | 111 | 596 | 75036 |
| Frans Van de Werf | 109 | 747 | 63537 |
| José Luis Zamorano | 105 | 695 | 133396 |
| Francisco Sánchez-Madrid | 102 | 527 | 43418 |
| Francesco Locatelli | 99 | 820 | 42454 |
| Roberto M. Lang | 96 | 823 | 56638 |
| Carlos Simón | 95 | 589 | 31147 |