Hospital General Universitario Gregorio Marañón

About: Hospital General Universitario Gregorio Marañón is a healthcare organization based out in Madrid, Spain. It is known for research contribution in the topics: Population & Transplantation. The organization has 11975 authors who have published 12386 publications receiving 244847 citations.

Definitions for the Sonographic Features of Joints in Healthy Children

Abstract: Objective Musculoskeletal ultrasonography (US) has potential in the assessment of disease activity and structural damage in childhood arthritides In order to assess pathology, the US characteristics of joints in healthy children need to be defined first The aim of this study was to develop definitions for the various components of the normal pediatric joint Methods The definitions were developed by an expert group and applicability was assessed on a collection of standardized scans of the knee and ankle joints by scoring the scans on a Likert scale The definitions were then modified and applicability was reassessed before sending the definitions for approval to a larger panel of experts A final scoring on stored images of all relevant joints at different ages followed Results Five definitions were developed addressing the articular bone, cartilage, joint capsule, epiphyseal ossification center, and synovial membrane In total, 224 US images of knees and ankles were acquired, of which 172 were selected for scoring An agreement of ≥80% was not met for any of the definitions, but after modifications, 81–97% agreement was reached This version of the definitions was approved by 15 US experts In the final validation exercise, all definitions reached an agreement of ≥80% for the shoulder, elbow, wrist, metacarpophalangeal hip, knee, ankle and metatarsophalangeal joint Conclusion US definitions for the normal pediatric joint were successfully developed through a Delphi process and validated in a practical exercise These results provide the basis to develop definitions for pathology and to support the standardized use of US in pediatric rheumatology

Consensus conference on chronic viral hepatitis and HIV infection: updated Spanish recommendations.

Abstract: Chronic hepatitis B and C represent a leading cause of morbidity and mortality among human immunodeficiency virus (HIV)-infected patients worldwide. New treatment options against both hepatitis B (HBV) and C (HCV) viruses have prompted us to update previous recommendations for the management of coinfected individuals. Fifteen topics (nine related to HCV, five to HBV and one to both viruses) were selected for this purpose. A panel of Spanish experts in the field was invited to review these areas and propose specific recommendations, which were scored according to the Infectious Disease Society of America (IDSA) grading system. These guidelines represent a comprehensive and updated overview on the management of hepatitis B and C in HIV-infected patients.