Institution
Hospital General Universitario Gregorio Marañón
Healthcare•Madrid, Spain•
About: Hospital General Universitario Gregorio Marañón is a healthcare organization based out in Madrid, Spain. It is known for research contribution in the topics: Population & Transplantation. The organization has 11975 authors who have published 12386 publications receiving 244847 citations.
Topics: Population, Transplantation, Myocardial infarction, Intensive care, COPD
Papers published on a yearly basis
Papers
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TL;DR: Although patients who died presented with worse respiratory situation at admission, this was not significantly different at tocilizumab administration and did not have an impact on outcome in the multivariate analysis.
77 citations
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TL;DR: The presence of MRSA carrying the mecC gene in Spain is confirmed, the ability of this livestock-associated MRSA to cause severe infections in humans and the need to perform culture-based susceptibility testing methods in order to detect these emerging strains is confirmed.
Abstract: Objectives Methicillin-resistant Staphylococcus aureus (MRSA) strains carrying the mecC gene have been reported from humans and animals from several European countries, but never from Spain. We describe the first isolates of mecC-positive MRSA of human origin collected in Spain and report a fatal case of bacteraemia. Methods Isolates were tested for phenotypic resistance using cefoxitin, tested for the mecA/mecC genes and toxin genes by PCR, and typed by staphylococcal cassette chromosome mec (SCCmec), PFGE, spa, multilocus sequence typing and agr. Results During 2008-13 five MRSA isolates showing resistance to cefoxitin and carrying the mecC gene were recovered at one hospital in Spain. In a review of 5505 S. aureus strains received at the Spanish National Reference Centre for Staphylococci from the same period, we found two additional mecC-positive isolates. The isolates were recovered from blood (two), wounds (two), joint fluid (one), urine (one) and a nasal swab (one). All MRSA were mecA negative, presented SCCmecXI, belonged to agr group III and to clonal complex 130, and were negative for the production of the toxin genes tst1, eta, etb, etd and Panton-Valentine leucocidin. Six isolates belonged to spa type t843 (ST130 and ST1945, where ST stands for sequence type) and one to spa type t6220 (ST1945). One patient with mecC-positive MRSA sepsis died in the emergency department. Conclusions We confirm the presence of MRSA carrying the mecC gene in Spain, the ability of this livestock-associated MRSA to cause severe infections in humans and the need to perform culture-based susceptibility testing methods in order to detect these emerging strains.
77 citations
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TL;DR: ASociedad Española de Diabetes (SED), Servicio de Endocrinología y Nutrición (SEEN), yGrupo de Urgencias de the SEMI, Madrid.
Abstract: aSociedad Española de Diabetes (SED). Servicio de Endocrinología y Nutrición. Hospital de la Santa Creu i Sant Pau. Barcelona. CIBER de Diabetes y Enfermedades Metabólicas Asociadas. CIBERDEM. España. bSociedad Española de Medicina Interna (SEMI). Servicio de Medicina Interna. Hospital General Universitario Gregorio Marañón. Madrid. España. cSociedad Española de Cardiología (SEC). Madrid. España. dSociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias (SEMICYUC). España. eGrupo de Urgencias de la SEMI. Madrid. España. fSociedad Española de Endocrinología y Nutrición (SEEN). Madrid. España.
77 citations
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TL;DR: The factors most strongly associated with delayed bleeding were right-sided lesions, aspirin use, and mucosal defects not closed by hemoclips.
77 citations
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TL;DR: Investigation of the frequency and severity of STD in COVID-19 patients and the association with demographic characteristics, hospital admission, symptoms, comorbidities, and blood biomarkers found an older age, being hospitalized and an increased level of C-reactive protein were factors associated with a better sense of smell and/or taste.
Abstract: Background and objective Since the initial anecdotal reports of coronavirus disease 2019 (COVID-19) from China, a growing number of studies have reported on smell and/or taste dysfunction (STD) Objective: The aim of our study was to investigate the frequency and severity of STD in COVID-19 patients and to evaluate the association with demographic characteristics, hospital admission, symptoms, comorbidities, and blood biomarkers Methods We performed a multicenter cross-sectional study on patients who were positive for SARS-CoV-2 (n=846) and controls (n=143) from 15 Spanish hospitals Data on STD were collected prospectively using an in-person survey The severity of STD was categorized using a visual analog scale We analyzed time to onset, recovery rate, time to recovery, hospital admission, pneumonia, comorbidities, smoking, and symptoms Results STD was at least 2-fold more common in COVID-19-positive patients than in controls COVID-19-positive hospitalized patients were older, with a lower frequency of STD, and recovered earlier than outpatients Analysis stratified by severity of STD showed that more than half of COVID-19 patients presented severe loss of smell (537%) or taste (522%); both senses were impaired in >90% In the multivariate analysis, older age (>60 years), being hospitalized, and increased C-reactive protein were associated with a better sense of smell and/or taste COVID-19-positive patients reported improvement in smell (456%) and taste (461%) at the time of the survey; in 906% this was within 2 weeks of infection Conclusion STD is a common symptom in COVID-19 and presents mainly in young and nonhospitalized patients More studies are needed to evaluate follow-up of chemosensory impairment
77 citations
Authors
Showing all 12014 results
Name | H-index | Papers | Citations |
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David H. Adams | 155 | 1613 | 117783 |
Stefanie Dimmeler | 147 | 574 | 81658 |
Stuart J. Pocock | 145 | 684 | 143547 |
M. I. Martínez | 134 | 1251 | 79885 |
Guy A. Rouleau | 129 | 884 | 65892 |
Jose L. Jimenez | 124 | 654 | 64226 |
Antoni Torres | 120 | 1238 | 65049 |
Paul P. Tak | 112 | 591 | 57689 |
Luis A. Diaz | 111 | 596 | 75036 |
Frans Van de Werf | 109 | 747 | 63537 |
José Luis Zamorano | 105 | 695 | 133396 |
Francisco Sánchez-Madrid | 102 | 527 | 43418 |
Francesco Locatelli | 99 | 820 | 42454 |
Roberto M. Lang | 96 | 823 | 56638 |
Carlos Simón | 95 | 589 | 31147 |