Institution
Hospital General Universitario Gregorio Marañón
Healthcare•Madrid, Spain•
About: Hospital General Universitario Gregorio Marañón is a healthcare organization based out in Madrid, Spain. It is known for research contribution in the topics: Population & Transplantation. The organization has 11975 authors who have published 12386 publications receiving 244847 citations.
Topics: Population, Transplantation, Myocardial infarction, Intensive care, COPD
Papers published on a yearly basis
Papers
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TL;DR: The available scientific evidence is reviewed and the most appropriate scales for the measurement and assessment of frailty are highlighted, some of which are more useful and have better predictive capacity than others, depending on the clinical context.
Abstract: Frailty is an age-associated clinical syndrome characterized by a decrease in physiological reserve in situations of stress, constituting a state of vulnerability that involves a higher risk of adverse events. Its prevalence in Spain is high, especially in elderly individuals with comorbidity and chronic diseases. In cardiovascular disease, frailty is associated worse clinical outcomes and higher morbidity and mortality in all scenarios, in both acute and chronic settings, and could consequently influence diagnosis and treatment. However, frailty is often not addressed or included when planning the management of elderly patients with heart disease. In this article, we review the available scientific evidence and highlight the most appropriate scales for the measurement and assessment of frailty, some of which are more useful and have better predictive capacity than others, depending on the clinical context. We also underline the importance of properly identifying and assessing frailty in order to include it in the treatment and care plan that best suits each patient.
73 citations
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TL;DR: The study underscores the value of CXCR4 expression as a useful marker for predicting outcome in patients with localized melanoma and supports that, among chemokine receptors, CX CR4 might be an appropriate therapeutic target for adjuvant therapy in patients at risk for metastatic disease.
Abstract: Tumor cell migration involved in metastases is a tightly regulated, nonrandom process. Chemokines have been identified as critical molecules guiding cell migration. We performed a prospective study to analyze a possible association between the expression of chemokine receptors CXCR3 and CXCR4 by primary melanoma and clinical outcome. Forty primary melanomas were available for analysis; 57% of the tumors expressed CXCR3 and 35% expressed CXCR4 by melanoma cells. At initial diagnosis, 5 patients had subclinical lymph node involvement and after a median follow-up time of 32 months, 2 additional patients developed regional lymph node metastases and 5 patients developed distant metastases. The expression of CXCR4, but not CXCR3, by melanoma cells in primary lesions was significantly associated with the presence of ulceration, increased tumor thickness, a greater risk of developing regional and distant metastases and a higher mortality rate. Our study underscores the value of CXCR4 expression as a useful marker for predicting outcome in patients with localized melanoma. In addition, our findings support that, among chemokine receptors, CXCR4 might be an appropriate therapeutic target for adjuvant therapy in patients at risk for metastatic disease.
72 citations
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TL;DR: Results suggest that abnormal growth (or more pronounced shrinkage during adolescence) of the frontal cortex represents a shared endophenotype for psychosis in adolescents with schizophrenia and bipolar disorder with psychotic symptoms.
72 citations
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TL;DR: Different approaches where light-sheet microscopy can achieve single-cell and subcellular resolution within microdevices are explored, and a few pointers on how these experiments may be improved are provided.
Abstract: JR acknowledges funding from EU H2020 FET Open project SENSITIVE, ID 801347 and Spanish Ministry of Economy and Competitiveness (MINECO) Grant FIS2016-77892-R. AM-B acknowledges funding from the MINECO (TEC2013-48552-C2-1-R, TEC2015-73064-EXP, TEC2016-78052-R), Beca Leonardo a Investigadores y Creadores Culturales 2017, Fundacion BBVA and EU Open project SENSITIVE. The CNIC is supported by the Ministerio de Ciencia, Innovacion y Universidades and the ProCNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505).
72 citations
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TL;DR: In patients with alcoholic fatty liver, metadoxine accelerates the normalization of liver function tests and the ultrasonographic changes, even in those who do not completely abstain from alcohol intake, and could be useful in the treatment of the early stages of alcoholic liver disease.
72 citations
Authors
Showing all 12014 results
Name | H-index | Papers | Citations |
---|---|---|---|
David H. Adams | 155 | 1613 | 117783 |
Stefanie Dimmeler | 147 | 574 | 81658 |
Stuart J. Pocock | 145 | 684 | 143547 |
M. I. Martínez | 134 | 1251 | 79885 |
Guy A. Rouleau | 129 | 884 | 65892 |
Jose L. Jimenez | 124 | 654 | 64226 |
Antoni Torres | 120 | 1238 | 65049 |
Paul P. Tak | 112 | 591 | 57689 |
Luis A. Diaz | 111 | 596 | 75036 |
Frans Van de Werf | 109 | 747 | 63537 |
José Luis Zamorano | 105 | 695 | 133396 |
Francisco Sánchez-Madrid | 102 | 527 | 43418 |
Francesco Locatelli | 99 | 820 | 42454 |
Roberto M. Lang | 96 | 823 | 56638 |
Carlos Simón | 95 | 589 | 31147 |