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Institution

Hotel Dieu Hospital

HealthcareKingston, Ontario, Canada
About: Hotel Dieu Hospital is a healthcare organization based out in Kingston, Ontario, Canada. It is known for research contribution in the topics: Population & Blood pressure. The organization has 1507 authors who have published 1294 publications receiving 50201 citations.


Papers
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Journal ArticleDOI
TL;DR: The results of a comprehensive and systematic clinical study of 324 patients with hereditary hemorrhagic telangiectasia selected from a total of 1,270 cases recruited by epidemiological survey suggested autosomal dominant inheritance.
Abstract: We report the results of a comprehensive and systematic clinical study of 324 patients with hereditary hemorrhagic telangiectasia, selected from a total of 1,270 cases recruited by epidemiological survey. In 94% of the cases, familial occurrence suggested autosomal dominant inheritance; maximum penetrance for at least one manifestation was 97%. Epistaxis was reported by 96% of the patients and, in more than 50%, developed before age 20. Heavy and frequent bleeding occurred mainly in middle-aged patients. Telangiectasia was documented in 74% of cases, half of whom were younger than 30 years. The frequency of involvement of the hands and wrists was 41%, and for the face, 33%. Visceral involvement was present in 25% of patients, with affected lungs and CNS in the young and gastrointestinal tract and liver in older patients. Symptomatic urinary tract involvement was seen in only two/324 patients. Involvement of other internal sites was not observed.

543 citations

Journal ArticleDOI
TL;DR: In this article, the structural and dynamic changes occurring during fibrinolysis of cross-linked plasma fibrin were analyzed using colloidal gold particles and confocal microscopy, showing that thin fibers were cleaved at a faster rate than thick ones.
Abstract: Abnormal fibrin architecture is thought to be a determinant factor of hypofibrinolysis. However, because of the lack of structural knowledge of the process of fibrin digestion, relationships between fibrin architecture and hypofibrinolysis remain controversial. To elucidate further structural and dynamic changes occurring during fibrinolysis, cross-linked plasma fibrin was labeled with colloidal gold particles, and fibrinolysis was followed by confocal microscopy. Morphological changes were characterized at fibrin network and fiber levels. The observation of a progressive disaggregation of the fibrin fibers emphasizes that fibrinolysis proceeds by transverse cutting rather than by progressive cleavage uniformly around the fiber. Plasma fibrin clots with a tight fibrin conformation made of thin fibers were dissolved at a slower rate than those with a loose fibrin conformation made of thicker (coarse) fibers, although the overall fibrin content remained constant. Unexpectedly, thin fibers were cleaved at a faster rate than thick ones. A dynamic study of FITC-recombinant tissue plasminogen activator distribution within the fibrin matrix during the course of fibrinolysis showed that the binding front was broader in coarse fibrin clots and moved more rapidly than that of fine plasma fibrin clots. These dynamic and structural approaches to fibrin digestion at the network and the fiber levels reveal aspects of the physical process of clot lysis. Furthermore, these results provide a clear explanation for the hypofibrinolysis related to a defective fibrin architecture as described in venous thromboembolism and in premature coronary artery disease.

477 citations

Journal ArticleDOI
TL;DR: A new simple and rapid method for quantitative semimicro determination of blood urea is presented, with a maximum adsorption at 530 mµ stable at room temperature and requiring 0.2 ml.
Abstract: A new simple and rapid method for quantitative semimicro determination of blood urea is presented. Diacetyl monoxime and thiosemicarbazide form in acid medium with urea a red color complex with a maximum adsorption at 530 mµ stable at room temperature and requiring 0.2 ml. of 1:10 blood filtrate.

476 citations

Journal ArticleDOI
TL;DR: Very-low-dose warfarin is a safe and effective method for prevention of thromboembolism in patients with metastatic breast cancer who are receiving chemotherapy.

476 citations

Journal ArticleDOI
TL;DR: Chronic infection by HCV is associated with an allostimulatory defect of monocyte-derived DC, possibly because these cells constitute an extrahepatic reservoir for the virus, which argues against an active immunosuppression-based mechanism.

428 citations


Authors

Showing all 1507 results

NameH-indexPapersCitations
Philippe Froguel166820118816
Claude Bouchard1531076115307
Jean-Pierre Després13473690118
Peter M. Nilsson124114182565
Jacob Selhub10635144698
Philippe Ravaud10161841409
Fabien Zoulim9664135807
Serge Gauthier9363752775
Michel E. Safar9054732590
Angelo Tremblay8646632751
Dominique Costagliola8659430289
Denis E. O'Donnell8140626131
Patrick Levy7838825755
Christian Trepo7841728322
Raphaël Porcher7849520708
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20231
20221
202145
202044
201955
201847