Showing papers by "Howard Hughes Medical Institute published in 1969"
TL;DR: Although the data suggest that coronary vasoconstriction occurred in patients with atherosclerotic lesions, no significant change in myocardial lactate exchange was noted after administration of propranolol, and beta-adrenergic blockade caused a decline in cardiac filling pressures and volumes at the dose level used in this study.
Abstract: The success of propranolol in treating the symptoms of angina pectoris has raised questions about the effects of beta-adrenergic blockade on the hemodynamic functions, myocardial mechanics, energetics, and metabolic functions. Five milligrams of propranolol was given intravenously to 27 human subjects, 18 with and nine without angiographically proven coronary atherosclerosis. The drug produced a decrease in externally measured indices of myocardial mechanical effort and consequently a fall in myocardial oxygen demands. The hemodynamic changes and resultant increases in myocardial oxygen consumption and coronary flow during supine leg exercise were also attenuated. Propranolol produced different changes in myocardial arteriovenous oxygen extraction depending upon whether the coronary circulation was normal or diseased. Although the data suggest that coronary vasoconstriction occurred in patients with atherosclerotic lesions, no significant change in myocardial lactate exchange was noted after administratio...
167 citations
TL;DR: Evidence was presented which indicated the slowest migrating component was responsible for the inhibitory activity of an inhibitor which was capable of interfering with complement mediated hemolysis of antibody sensitized sheep E.
115 citations
TL;DR: A highly significant correlation has been demonstrated between abnormalities at the interlobar and arcuate artery level in selective renal arteriograms of sixty-six patients with essential hypertension and several clinical indices including the age of the patient and the duration, severity and presence of complications of hypertension.
86 citations
TL;DR: In this article, extracts from human E stromata were found to be capable of causing inhibition of the complement mediated lysis of antibody sensitized sheep red cells, and the inhibition resulted from an increase in the rate of SAbC′la, 4, 2a decay to the SAbc′la 4 state.
85 citations
TL;DR: Renal vein renin activity ratio and absolute renal vein renIn activity from the involved kidney provided the most accurate means of predicting surgical results, and the absolute level correlated correctly in all but one of fourteen patients.
67 citations
TL;DR: A significant increase in renin secretion was found in patients with essential hypertension complicated by moderately severe small artery disease in the kidney and reduced renal blood flow, and the possibility that the increased renin gland secretion contributed to the severity of the hypertension in these patients.
56 citations
2 citations