Showing papers by "Howard Hughes Medical Institute published in 1973"
TL;DR: A comparative metabolic study indicates that both chloramphenicol and thiAMPhenicol are potent inhibitors of mitochondrial protein synthesis and that in contrast to chlorampshenicol which at high concentrations inhibits DNA synthesis, thiampenicol had little effect on DNA synthesis.
48 citations
TL;DR: 3-Hydroxybenzoate 4-hydroxylase has been purified to homogeneity from extracts from extracts pf Ps .
44 citations
TL;DR: 3-hydroxybenzoate 6-hydroxylase thus resembles other flavoprotein hydroxylases in the general regulatory properties dictated by their aromatic substrates, pseudosubstrates or effectors.
42 citations
TL;DR: It is concluded that autoregulation in peripheral vascular beds could result in autoreGulation of total peripheral flow after simple baroreceptor denervation, however, the barore receptor reflexes normally achieved regulation of aortic pressure by inhibiting autore gulation in much of the peripheral circulation.
Abstract: Although many organs maintain constant blood flow despite changes in perfusion pressure, autoregulation in the total systemic circulation has only been reported in animals after destruction of the central nervous system. The present study examined the role of the baroreceptors in this autoregulatory response in open-chest dogs anesthetized with chloralose-urethane. Cardiac output was varied over nearly a twofold range by altering myocardial contractility with either inotropic agents or controlled myocardial ischemia. Cardiac output, determined by dye dilution, and mean aortic pressure stabilized within 3 minutes after the start of infusions of calcium (15-62 mg/min) into the cannulated left coronary artery or the reduction of coronary flow. With bilateral vagotomy and carotid sinus denervation, autoregulation of total peripheral flow was observed. Thus, changes in cardiac output evoked parallel changes in total peripheral resistance and wide variations in aortic pressure. However, with the baroreceptors intact, changes in cardiac output evoked inverse changes in total peripheral resistance which resulted in regulation of aortic pressure. We concluded that autoregulation in peripheral vascular beds could result in autoregulation of total peripheral flow after simple baroreceptor denervation. However, the baroreceptor reflexes normally achieved regulation of aortic pressure by inhibiting autoregulation in much of the peripheral circulation.
35 citations
TL;DR: Rat ovarian tumor cells grown in culture secrete a fibrinolysin which can be obtained in highly purified form from conditioned serum-free medium and may be a property associated with neoplasia and is currently under active investigation.
14 citations
TL;DR: The extensive studies on rabbit glycogen phosphorylase pioneered by the Cork and extended by many investigators in the field have served as the cornerstone for the present understanding of the structure-function relationship of the phosphoryLase molecule.
Abstract: The extensive studies on rabbit glycogen phosphorylase pioneered by the Cork and extended by many investigators in the field have served as the cornerstone for our present understanding of the structure-function relationship of the phosphorylase molecule. Although great similarities have been observed among the many phosphorylases studied, some major differences have also been found among muscle phosphorylases of different species,I-'; as well as among phosphorylases from different tissues of the same species, for example rabbit muscle versus rabbit liver,s bovine muscle versus bovine corpus luteum,l\" human muscle
8 citations