Showing papers by "Howard Hughes Medical Institute published in 1975"
TL;DR: The tumor was responsive to physiologic stimuli known to affect glucagon secretion, elevations of plasma glucagon levels with oral and dietary glucose suggest regulation of secretion by intestinal factors, and improvement of glucose tolerance with alpha adrenergic blockade may be related to increased insulin secretion.
90 citations
TL;DR: It is demonstrated that the short-term administration of furosemide in large doses does not improve renal hemodynamics or alter the clinical course of patients with established acute oliguric renal failure.
64 citations
TL;DR: Soluble enzyme-carbohydrate conjugates have been prepared by coupling trypsin, α-amylase, and β-amymylase to cyanogen bromide activated dextran, which are more stable to heat than the respective native enzymes.
64 citations
TL;DR: Observations show that M-proteins may interfere with lipid transport by at least two mechanisms and illustrate the clinical diversity of xanthomatous myeloma.
34 citations
TL;DR: In vitro analysis of the enzymes participating directly in the two biosynthetic pathways for which IMP is a substrate proposes that the intracellular level of GTP may be more critical than previously recognized.
Abstract: In the present discussion we have presented our views on how purine biosynthesis de novo is regulated in man. The rate of the initital step unique to purine ribonucleotide biosynthesis de novo is controlled by the intracellular concentration of PP-ribose-P and purine ribonucleotides. This critical interaction of PP-ribose-P and purine ribonucleotides may be explained by a change in the physical properties of the enzyme that catalyzes this reaction. The first branch point in the pathway, following this initial step involves the utilization of IMP. Based on an in vitro analysis of the enzymes participating directly in the two biosynthetic pathways for which IMP is a substrate, we propose that the intracellular level of GTP may be more critical than previously recognized.
22 citations
TL;DR: An exo-β-glucan hydrolase, present in the digestive juice of the snail, Helix pomatia, has been purified to homogeneity by chromatography on Bio-Gel P-60, Sephadex G-200, DEAE-cellulose, and DEAE -Sephadesadex as discussed by the authors.
21 citations
Journal Article•
TL;DR: It is postulated that the concentration of colony-stimulating factor in the cell milieu in vivo may play a significnat role in determining the occurrence or degree of leukopenia from some potentially myelotoxic drugs.
19 citations
TL;DR: Fibrinolysin secreted by cultured R2426 rat breast carcinoma cells has been purified and partially characterized and had direct hydrolytic action on plasminogen-free fibrinogen, fibr in, and TAME.
15 citations
TL;DR: The fibrinolysin secreted by the rat tumor cells was immunologically distinct from human, horse, and calf plasmin.
7 citations