Institution
Howard Hughes Medical Institute
Nonprofit•Chevy Chase, Maryland, United States•
About: Howard Hughes Medical Institute is a nonprofit organization based out in Chevy Chase, Maryland, United States. It is known for research contribution in the topics: Gene & RNA. The organization has 20371 authors who have published 34677 publications receiving 5247143 citations. The organization is also known as: HHMI & hhmi.org.
Topics: Gene, RNA, Population, Cellular differentiation, Transcription factor
Papers published on a yearly basis
Papers
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TL;DR: Axin is a novel inhibitor of Wnt signaling and regulates an early step in embryonic axis formation in mammals and amphibians.
925 citations
TL;DR: The site-specific recombination system of the yeast 2 micron plasmid, the FLP recombinase and its recombination targets (FRTs), into the genome of Drosophila, producing white-eyed and dark-red-eyed progeny.
924 citations
TL;DR: PC hydrolysis by PLA2, PLC or PLD is a widespread response elicited by most growth factors, cytokines, neurotransmitters, hormones and other extracellular signals and the mechanisms can involve G-proteins, PKC, Ca2+ and tyrosine kinase activities.
924 citations
TL;DR: Molecular modeling was used to identify the caspase recruitment and WD40 domains within the apoptosome and to infer likely positions of the CED4 homology motif and cytochrome c, suggesting a plausible role for cy tochrome c in apoptosomes assembly.
924 citations
TL;DR: A robust pipeline is established for the discovery of novel gene chimaeras using high-throughput sequencing of cancer cells to discover novel gene fusions resulting in chimaeric transcripts in cancer cell lines and tumours.
Abstract: Recurrent gene fusions, typically associated with haematological malignancies and rare bone and soft-tissue tumours, have recently been described in common solid tumours. Here we use an integrative analysis of high-throughput long- and short-read transcriptome sequencing of cancer cells to discover novel gene fusions. As a proof of concept, we successfully used integrative transcriptome sequencing to 're-discover' the BCR-ABL1 (ref. 10) gene fusion in a chronic myelogenous leukaemia cell line and the TMPRSS2-ERG gene fusion in a prostate cancer cell line and tissues. Additionally, we nominated, and experimentally validated, novel gene fusions resulting in chimaeric transcripts in cancer cell lines and tumours. Taken together, this study establishes a robust pipeline for the discovery of novel gene chimaeras using high-throughput sequencing, opening up an important class of cancer-related mutations for comprehensive characterization.
923 citations
Authors
Showing all 20486 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Bert Vogelstein | 247 | 757 | 332094 |
| Richard A. Flavell | 231 | 1328 | 205119 |
| Steven A. Rosenberg | 218 | 1204 | 199262 |
| Kenneth W. Kinzler | 215 | 640 | 243944 |
| Robert J. Lefkowitz | 214 | 860 | 147995 |
| Rob Knight | 201 | 1061 | 253207 |
| Irving L. Weissman | 201 | 1141 | 172504 |
| Ronald M. Evans | 199 | 708 | 166722 |
| Francis S. Collins | 196 | 743 | 250787 |
| Craig B. Thompson | 195 | 557 | 173172 |
| Thomas C. Südhof | 191 | 653 | 118007 |
| Joan Massagué | 189 | 408 | 149951 |
| Stuart H. Orkin | 186 | 715 | 112182 |
| John P. A. Ioannidis | 185 | 1311 | 193612 |
| Eric R. Kandel | 184 | 603 | 113560 |