Institution
Howard Hughes Medical Institute
Nonprofit•Chevy Chase, Maryland, United States•
About: Howard Hughes Medical Institute is a nonprofit organization based out in Chevy Chase, Maryland, United States. It is known for research contribution in the topics: Gene & RNA. The organization has 20371 authors who have published 34677 publications receiving 5247143 citations. The organization is also known as: HHMI & hhmi.org.
Topics: Gene, RNA, Population, Receptor, Cellular differentiation
Papers published on a yearly basis
Papers
More filters
TL;DR: It is shown that proliferating mammalian cells have a cell-cycle checkpoint that responds to glucose availability and is regulated by AMP-activated protein kinase (AMPK), acell-cycle arrest that occurs despite continued amino acid availability and active mTOR.
1,541 citations
TL;DR: The identification of telomerase in HeLa cells with only approximately 100 telomeres indicates that telomersase-mediated telomere maintenance is conserved throughout eukaryotes.
1,538 citations
TL;DR: Methylation patterns at orthologous loci are strongly conserved between human and mouse even though many methylated sites do not show sequence conservation notably higher than background, which suggests that the DNA elements that direct the methylation represent only a small fraction of the region or lie at some distance from the site.
1,536 citations
TL;DR: This work purified an ESC-E(Z) complex from Drosophila embryos and found four major subunits: ESC, E(Z), NURF-55, and the PcG repressor, SU( Z)12, which methylates lysine-27 of histone H3.
1,534 citations
TL;DR: It is anticipated that super-resolution fluorescence microscopy will become a widely used tool for cell and tissue imaging to provide previously unobserved details of biological structures and processes.
Abstract: Achieving a spatial resolution that is not limited by the diffraction of light, recent developments of super-resolution fluorescence microscopy techniques allow the observation of many biological structures not resolvable in conventional fluorescence microscopy. New advances in these techniques now give them the ability to image three-dimensional (3D) structures, measure interactions by multicolor colocalization, and record dynamic processes in living cells at the nanometer scale. It is anticipated that super-resolution fluorescence microscopy will become a widely used tool for cell and tissue imaging to provide previously unobserved details of biological structures and processes.
1,534 citations
Authors
Showing all 20486 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Bert Vogelstein | 247 | 757 | 332094 |
| Richard A. Flavell | 231 | 1328 | 205119 |
| Steven A. Rosenberg | 218 | 1204 | 199262 |
| Kenneth W. Kinzler | 215 | 640 | 243944 |
| Robert J. Lefkowitz | 214 | 860 | 147995 |
| Rob Knight | 201 | 1061 | 253207 |
| Irving L. Weissman | 201 | 1141 | 172504 |
| Ronald M. Evans | 199 | 708 | 166722 |
| Francis S. Collins | 196 | 743 | 250787 |
| Craig B. Thompson | 195 | 557 | 173172 |
| Thomas C. Südhof | 191 | 653 | 118007 |
| Joan Massagué | 189 | 408 | 149951 |
| Stuart H. Orkin | 186 | 715 | 112182 |
| John P. A. Ioannidis | 185 | 1311 | 193612 |
| Eric R. Kandel | 184 | 603 | 113560 |