scispace - formally typeset
Search or ask a question
Institution

Humboldt University of Berlin

EducationBerlin, Germany
About: Humboldt University of Berlin is a education organization based out in Berlin, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 33671 authors who have published 61781 publications receiving 1908102 citations. The organization is also known as: Humboldt-Universität zu Berlin & Universitas Humboldtiana Berolinensis.


Papers
More filters
Journal ArticleDOI
TL;DR: IL-15 is a potent, general inhibitor of apoptosis in vitro and in vivo with intriguing therapeutic potential and is completely protected from lethal hepatic failure.
Abstract: Interleukin-15 shares many biological activities with IL-2 and signals through the IL-2 receptor β and γ chains1–3. However, IL-15 and IL-2 differ in their controls of expression and secretion, their range of target cells and their functional activities3–7. These dissimilarities may include differential effects on apoptosis. For example, IL-2 induces or inhibits T-cell apoptosis in vitro, depending on T-cell activation8, whereas IL-15 inhibits cytokine deprivation-induced apoptosis in activated T cells9. Studying whether and how IL-15 modulates distinct apoptosis pathways10–12, we show here that apoptosis induced by anti-Fas, anti-CD3, dexamethasone, and/or anti-IgM in activated human T and B cells in vitro is inhibited by IL-15 in a manner dependent on RNA synthesis. In vivo, anti-Fas-induced lethal multisystem apoptosis in mice is suppressed by a novel IL-15–lgG2b fusion protein. Only IL-15, but not IL-2, completely protected from lethal hepatic failure. Thus, IL-15 is a potent, general inhibitor of apoptosis in vitro and in vivo with intriguing therapeutic potential.

328 citations

Journal ArticleDOI
TL;DR: A study is presented in which manipulation of music synchrony significantly altered subjects' perceptions of music quality, and in which subjects’ perceptions ofMusic quality were correlated with their perceptions of coalition quality, supporting the hypothesis that music and dance may have evolved as a coalition signaling system that could credibly communicate coalition quality.
Abstract: Evidence suggests that humans might have neurological specializations for music processing, but a compelling adaptationist account of music and dance is lacking The sexual selection hypothesis cannot easily account for the widespread performance of music and dance in groups (especially synchronized performances), and the social bonding hypothesis has severe theoretical difficulties Humans are unique among the primates in their ability to form cooperative alliances between groups in the absence of consanguineal ties We propose that this unique form of social organization is predicated on music and dance Music and dance may have evolved as a coalition signaling system that could, among other things, credibly communicate coalition quality, thus permitting meaningful cooperative relationships between groups This capability may have evolved from coordinated territorial defense signals that are common in many social species, including chimpanzees We present a study in which manipulation of music synchrony significantly altered subjects’ perceptions of music quality, and in which subjects’ perceptions of music quality were correlated with their perceptions of coalition quality, supporting our hypothesis Our hypothesis also has implications for the evolution of psychological mechanisms underlying cultural production in other domains such as food preparation, clothing and body decoration, storytelling and ritual, and tools and other artifacts

327 citations

Journal ArticleDOI
TL;DR: It is demonstrated that default-mode network NBRs are reduced in MDD and modulate these patients' abnormally negative emotions.

327 citations

Journal ArticleDOI
TL;DR: It was concluded that plain chest radiographs can essentially be used to assess clavicular ossification and if overlap in posterior-anterior views impedes evaluation, a lateral view should also be taken to facilitate age estimation.
Abstract: Radiological assessment of the degree of ossification of the medial clavicular epiphyseal cartilage plays a vital part in forensic age diagnosis of living adolescents and young adults. A total of 873 plain chest radiographs requested by the staff medical officer for members of staff aged 16–30 at the University Hospital Charite were evaluated retrospectively. Of these X-rays 699 permitted an assessment of ossification of at least 1 side of the clavicle. In addition to the customary stages (1: non-ossified epiphysis, 2: discernible ossification centre, 3: partial fusion, 4: total fusion) a stage 5 was also defined, characterised by the disappearance of the epiphyseal scar following total fusion. The earliest age at which stage 3 was detected in either gender was 16 years. Stage 4 was first observed in women at 20 years and in men at 21 years. In both genders, the earliest observation of stage 5 was at 26 years. It was concluded that plain chest radiographs can essentially be used to assess clavicular ossification. In practice, if overlap in posterior-anterior views impedes evaluation, a lateral view should also be taken to facilitate age estimation. In forensic practice the reference values of the present paper should be applied.

326 citations

Journal ArticleDOI
TL;DR: The role of perceived risk of COVID-19 (i.e., perceived likelihood of infection, perceived disease severity, and disease-related worry) and perceived safety of a prospective vaccine against COvid-19 in predicting intentions to accept a CO VID-19 vaccine is investigated.

326 citations


Authors

Showing all 34115 results

NameH-indexPapersCitations
Karl J. Friston2171267217169
Peer Bork206697245427
Raymond J. Dolan196919138540
Stefan Schreiber1781233138528
Andreas Pfeiffer1491756131080
Thomas Hebbeker1481984114004
Thomas Lohse1481237101631
Jean Bousquet145128896769
Hermann Kolanoski145127996152
Josh Moss139101989255
R. D. Kass1381920107907
W. Kozanecki138149899758
U. Mallik137162597439
C. Haber135150798014
Christophe Royon134145390249
Network Information
Related Institutions (5)
Ludwig Maximilian University of Munich
161.5K papers, 5.7M citations

96% related

Heidelberg University
119.1K papers, 4.6M citations

94% related

Technische Universität München
123.4K papers, 4M citations

94% related

Radboud University Nijmegen
83K papers, 3.2M citations

93% related

University of Zurich
124K papers, 5.3M citations

93% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023208
2022747
20214,727
20204,083
20193,579
20183,143