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Institution

Humboldt University of Berlin

EducationBerlin, Germany
About: Humboldt University of Berlin is a education organization based out in Berlin, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 33671 authors who have published 61781 publications receiving 1908102 citations. The organization is also known as: Humboldt-Universität zu Berlin & Universitas Humboldtiana Berolinensis.


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Journal ArticleDOI
TL;DR: The experiments present the first evidence that the amount of proteasomes in mammalia is regulated at the transcriptional level and that there exists an autoregulatory feedback mechanism that allows the compensation of reduced proteasome activity.

290 citations

Journal ArticleDOI
TL;DR: An embodied emotion regulation framework is proposed as a multilevel approach for understanding psychobiological changes due to mindfulness meditation regarding its effect on emotion regulation.
Abstract: There is increasing interest in the beneficial clinical effects of mindfulness-based interventions (MBIs). Research has demonstrated their efficacy in a wide range of psychological conditions characterized by emotion dysregulation. Neuroimaging studies have evidenced functional and structural changes in a myriad of brain regions mainly involved in attention systems, emotion regulation and self-referential processing. In this article we review studies on psychological and neurobiological correlates across different empirically derived models of research, including dispositional mindfulness, mindfulness induction, MBIs and expert meditators in relation to emotion regulation. From the perspective of recent findings in the neuroscience of emotion regulation, we discuss the interplay of top-down and bottom-up emotion regulation mechanisms associated with different mindfulness models. From a phenomenological and cognitive perspective, authors have argued that mindfulness elicits a “mindful emotion regulation” strategy; however, from a clinical perspective, this construct has not been properly differentiated from other strategies and interventions within MBIs. In this context we propose the distinction between top-down and bottom-up mindfulness based emotion regulation strategies. Furthermore, we propose an embodied emotion regulation framework as a multilevel approach for understanding psychobiological changes due to mindfulness meditation regarding its effect on emotion regulation. Finally, based on clinical neuroscientific evidence on mindfulness, we open perspectives and dialogues regarding commonalities and differences between MBIs and other psychotherapeutic strategies for emotion regulation.

290 citations

Journal ArticleDOI
TL;DR: This review summarizes recent progress on the identification and characterization of the various flippases and the demonstration of their biological functions.
Abstract: The typically distinct phospholipid composition of the two leaflets of a membrane bilayer is generated and maintained by bi-directional transport (flip-flop) of lipids between the leaflets. Specific membrane proteins, termed lipid flippases, play an essential role in this transport process. Energy-independent flippases allow common phospholipids to equilibrate rapidly between the two monolayers and also play a role in the biosynthesis of a variety of glycoconjugates such as glycosphingolipids, N-glycoproteins, and glycosylphosphatidylinositol (GPI)-anchored proteins. ATP-dependent flippases, including members of a conserved subfamily of P-type ATPases and ATP-binding cassette transporters, mediate the net transfer of specific phospholipids to one leaflet of a membrane and are involved in the creation and maintenance of transbilayer lipid asymmetry of membranes such as the plasma membrane of eukaryotes. Energy-dependent flippases also play a role in the biosynthesis of glycoconjugates such as bacterial lipopolysaccharide. This review summarizes recent progress on the identification and characterization of the various flippases and the demonstration of their biological functions.

290 citations

Journal ArticleDOI
TL;DR: The Jena Experiment as discussed by the authors investigated the link between plant diversity and soil carbon storage and found that higher diversity might lead to higher soil carbon sequestration in the long-term and therefore the conservation of biodiversity might play a role in greenhouse gas mitigation.
Abstract: Increasing atmospheric CO 2 concentration and related climate change have stimulated much interest in the potential of soils to sequester carbon. In 'The Jena Experiment', a managed grassland experiment on a former agricultural field, we investigated the link between plant diversity and soil carbon storage. The biodiversity gradient ranged from one to 60 species belonging to four functional groups. Stratified soil samples were taken to 30 cm depth from 86 plots in 2002, 2004 and 2006, and organic carbon contents were determined. Soil organic carbon stocks in 0-30 cm decreased from 7.3 kg C m -2 in 2002 to 6.9 kg C m -2 2 in 2004, but had recovered to 7.8 kg C m 2 by 2006. During the first 2 years, carbon storage was limited to the top 5 cm of soil while below 10 cm depth, carbon was lost probably as short-term effect of the land use change. After 4 years, carbon stocks significantly increased within the top 20 cm. More importantly, carbon storage significantly increased with sown species richness (log-transformed) in all depth segments and even carbon losses were significantly smaller with higher species richness. Although increasing species diversity increased root biomass production, statistical analyses revealed that species diversity per se was more important than biomass production for changes in soil carbon. Below 20 cm depth, the presence of one functional group, tall herbs, significantly reduced carbon losses in the beginning of the experiment. Our analysis indicates that plant species richness and certain plant functional traits accelerate the build-up of new carbon pools within 4 years. Additionally, higher plant diversity mitigated soil carbon losses in deeper horizons. This suggests that higher biodiversity might lead to higher soil carbon sequestration in the long-term and therefore the conservation of biodiversity might play a role in greenhouse gas mitigation.

290 citations

Journal ArticleDOI
Felix Aharonian1, A. G. Akhperjanian1, A. R. Bazer-Bachi, M. Beilicke1, Wystan Benbow1, David Berge1, Konrad Bernlöhr1, C. Boisson, O. Bolz1, V. Borrel, Ilana M. Braun1, F. Breitling2, A. M. Brown2, Rolf Bühler1, I. Büsching3, Svenja Carrigan1, P. M. Chadwick2, L.-M. Chounet, R. Cornils1, Luigi Costamante1, B. Degrange, Hugh Dickinson2, A. Djannati-Ataï, L. O'c. Drury4, Guillaume Dubus, Kathrin Egberts1, Dimitrios Emmanoulopoulos5, P. Espigat, F. Feinstein, E. Ferrero5, G. Fontaine, Seb. Funk6, Stefan Funk1, Y. A. Gallant, B. Giebels, J. F. Glicenstein, P. Goret, C. Hadjichristidis2, D. Hauser1, M. Hauser5, G. Heinzelmann7, Gilles Henri, G. Hermann1, Jim Hinton1, Werner Hofmann1, M. Holleran3, Dieter Horns1, A. Jacholkowska, O. C. de Jager3, B. Khélifi, Nu. Komin8, A. Konopelko1, I. J. Latham2, R. Le Gallou2, Anne Lemiere, M. Lemoine-Goumard, Thomas Lohse6, Jean Michel Martin9, O. Martineau-Huynh9, A. Marcowith, Conor Masterson1, T. J. L. McComb2, M. de Naurois1, D. Nedbal1, S. J. Nolan2, A. Noutsos2, K. J. Orford1, J. L. Osborne1, M. Ouchrif9, M. Panter1, G. Pelletier, S. Pita, Gerd Pühlhofer1, Michael Punch, B. C. Raubenheimer3, Martin Raue1, S. M. Rayner2, A. Reimer10, Olaf Reimer10, J. Ripken7, L. Rob11, L. Rolland12, Gavin Rowell1, V. Sahakian13, L. Saugé, S. Schlenker6, Reinhard Schlickeiser10, Ullrich Schwanke6, Helene Sol, D. Spangler2, Felix Spanier10, R. Steenkamp14, C. Stegmann15, G. Superina, J.-P. Tavernet9, Regis Terrier, C. G. Théoret, M. Tluczykont, C. van Eldik1, G. Vasileiadis, Christo Venter3, P. Vincent9, Heinrich J. Völk1, Stefan Wagner5, Martin Ward2 
TL;DR: In this article, a high-energy Stereoscopic system of Cherenkov Telescopes (H.E.S.S) was used to observe LS 5039, a High Mass X-ray Binary comprising a massive star and a compact object.
Abstract: New observations of LS 5039, a High Mass X-ray Binary comprising a massive star and compact object, were carried out with the High Energy Stereoscopic System of Cherenkov Telescopes (H.E.S.S.) in 2005 at very high energy (VHE) gamma-ray energies. These observations reveal that its flux and energy spectrum are modulated with the 3.9 day orbital period of the binary system. This is the first time in gamma-ray astronomy that orbital modulation has been observed, and periodicity clearly established using ground-based gamma-ray detectors. The VHE gamma-ray emission is largely confined to half of the orbit, peaking around the inferior conjunction epoch of the compact object. For this epoch, there is also a hardening of the energy spectrum in the energy range between 0.2 TeV and a few TeV. The flux vs. orbital phase profile provides the first clear indication of gamma-ray absorption via pair production within an astrophysical source, a process which is expected to occur if the gamma-ray production site is situated within ~1 AU of the compact object. Moreover the production region size must be not significantly greater than the binary separation (~0.15 AU). Notably, these constraints are also considerably smaller than the collimated outflows or jets (extending out to ~1000 AU) observed in LS 5039. The spectral hardening could arise from variations with phase in the maximum electron energies, and/or the dominant VHE gamma-ray production mechanism.

290 citations


Authors

Showing all 34115 results

NameH-indexPapersCitations
Karl J. Friston2171267217169
Peer Bork206697245427
Raymond J. Dolan196919138540
Stefan Schreiber1781233138528
Andreas Pfeiffer1491756131080
Thomas Hebbeker1481984114004
Thomas Lohse1481237101631
Jean Bousquet145128896769
Hermann Kolanoski145127996152
Josh Moss139101989255
R. D. Kass1381920107907
W. Kozanecki138149899758
U. Mallik137162597439
C. Haber135150798014
Christophe Royon134145390249
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023208
2022747
20214,727
20204,083
20193,579
20183,143