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Institution

Humboldt University of Berlin

EducationBerlin, Germany
About: Humboldt University of Berlin is a education organization based out in Berlin, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 33671 authors who have published 61781 publications receiving 1908102 citations. The organization is also known as: Humboldt-Universität zu Berlin & Universitas Humboldtiana Berolinensis.


Papers
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Journal ArticleDOI
TL;DR: The data indicate that avoidance measures in the domestic environment aimed at the primary prevention of allergen-driven sensitization should be introduced at the earliest possible stage, if possible during infancy.
Abstract: Background: The purpose of the study was to investigate the influence of environmental allergen exposure on allergic sensitization in infancy and early childhood. Methods: A cohort of 1314 newborns was recruited and followed up prospectively at the ages 12, 24, and 36 months. The levels of major mite (Der p 1 and Der f 1) and cat (Fel d 1) allergens were determined from domestic carpet dust samples by sandwich ELISA. Specific serum IgE antibodies to mite and cat allergens were determined by CAP fluoroimmunoassay (Pharmacia). Logistic regression was used to assess the effects of allergen exposure, age, family history, and cord blood IgE simultaneously on the risk of sensitization. Results: Children, who had been found to be sensitized at least once during the first 3 years of life, were found to be exposed to significantly higher house dust mite (median, 868 ng/gm vs 210 ng/gm; p =0.001) and cat (median, 150 ng/gm vs 64 ng/gm; p =0.011) allergen concentrations in domestic carpet dust compared with the group without sensitization. In homes with low (≤25th percentile) dust concentrations, the risk of sensitization to mite (1.6%) and cat (2.0%) is low, compared with 6.5% for mite and 6.3% for cat if the domestic exposure is above the 75th percentile. The dose-response relationships between allergen levels and sensitization indicate that the increase in sensitization risk at low allergen levels is more pronounced in cat allergy ( p =0.002) than in mite allergy ( p =0.026). In the group with a positive family history, lower mite and cat allergen concentrations are needed to achieve specific sensitization compared with the group with a negative family history. Conclusion: Our data indicate that avoidance measures in the domestic environment aimed at the primary prevention of allergen-driven sensitization should be introduced at the earliest possible stage, if possible during infancy. (J Allergy Clin Immunol 1997;99:763–9.)

567 citations

Journal ArticleDOI
TL;DR: A cation-conducting channelrhodopsin (VChR1) from Volvox carteri that can drive spiking at 589 nm, with excitation maximum red-shifted ∼70 nm compared with ChR2 is described, thereby defining a functionally distinct third category of microbial rhodopin proteins.
Abstract: The introduction of two microbial opsin-based tools, channelrhodopsin-2 (ChR2) and halorhodopsin (NpHR), to neuroscience has generated interest in fast, multimodal, cell type-specific neural circuit control. Here we describe a cation-conducting channelrhodopsin (VChR1) from Volvox carteri that can drive spiking at 589 nm, with excitation maximum red-shifted approximately 70 nm compared with ChR2. These results demonstrate fast photostimulation with yellow light, thereby defining a functionally distinct third category of microbial rhodopsin proteins.

567 citations

Journal ArticleDOI
TL;DR: In this article, a new correspondence between four-dimensional conformal field theories with extended supersymmetry and two-dimensional chiral algebras was described, where the meromorphic correlators of the chiral algebra compute correlators in a protected sector of the fourdimensional theory.
Abstract: We describe a new correspondence between four-dimensional conformal field theories with extended supersymmetry and two-dimensional chiral algebras. The meromorphic correlators of the chiral algebra compute correlators in a protected sector of the four-dimensional theory. Infinite chiral symmetry has far-reaching consequences for the spectral data, correlation functions, and central charges of any four-dimensional theory with $${\mathcal{N}=2}$$ superconformal symmetry.

563 citations

Journal ArticleDOI
TL;DR: This review provides a summary of the different conceptual strategies for addressing molecular switches in the visible and near-infrared regions of the optical spectrum and tremendously extend the scope of photoswitchable systems for future applications and technologies.
Abstract: The ability to influence key properties of molecular systems by using light holds much promise for the fields of materials science and life sciences. The cornerstone of such systems is molecules that are able to reversibly photoisomerize between two states, commonly referred to as photoswitches. One serious restriction to the development of functional photodynamic systems is the necessity to trigger switching in at least one direction by UV light, which is often damaging and penetrates only partially through most media. This review provides a summary of the different conceptual strategies for addressing molecular switches in the visible and near-infrared regions of the optical spectrum. Such visible-light-activated molecular switches tremendously extend the scope of photoswitchable systems for future applications and technologies.

562 citations


Authors

Showing all 34115 results

NameH-indexPapersCitations
Karl J. Friston2171267217169
Peer Bork206697245427
Raymond J. Dolan196919138540
Stefan Schreiber1781233138528
Andreas Pfeiffer1491756131080
Thomas Hebbeker1481984114004
Thomas Lohse1481237101631
Jean Bousquet145128896769
Hermann Kolanoski145127996152
Josh Moss139101989255
R. D. Kass1381920107907
W. Kozanecki138149899758
U. Mallik137162597439
C. Haber135150798014
Christophe Royon134145390249
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023208
2022747
20214,727
20204,083
20193,579
20183,143