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Institution

Humboldt University of Berlin

EducationBerlin, Germany
About: Humboldt University of Berlin is a education organization based out in Berlin, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 33671 authors who have published 61781 publications receiving 1908102 citations. The organization is also known as: Humboldt-Universität zu Berlin & Universitas Humboldtiana Berolinensis.


Papers
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Journal ArticleDOI
Justin Albert1, E. Aliu, H. Anderhub, P. Antoranz2, A. Armada, M. Asensio2, C. Baixeras3, Juan Abel Barrio2, M. Bartelt4, H. Bartko5, Denis Bastieri6, S. R. Bavikadi7, W. Bednarek8, K. Berger1, Ciro Bigongiari6, Adrian Biland, E. Bisesi7, R. K. Bock5, Pol Bordas9, Valentí Bosch-Ramon9, Thomas Bretz1, I. Britvitch, M. Camara2, E. Carmona5, Ashot Chilingarian10, Stefano Ciprini, J. A. Coarasa5, S. Commichau, Jose Luis Contreras2, Juan Cortina, V. Curtef4, V. Danielyan10, Francesco Dazzi6, A. De Angelis7, R. de los Reyes2, B. De Lotto7, E. Domingo-Santamaría, Daniela Dorner1, Michele Doro6, Manel Errando, Michela Fagiolini11, Daniel Ferenc12, E. Fernandez, R. Firpo, Jose Flix, M. V. Fonseca2, Ll. Font3, M. Fuchs5, Nicola Galante11, M. Garczarczyk5, Markus Gaug6, Maria Giller8, Florian Goebel5, D. Hakobyan10, Masaaki Hayashida5, T. Hengstebeck13, D. Höhne1, J. Hose5, C. C. Hsu5, Paula Gina Isar5, P. Jacon8, O. Kalekin13, R. Kosyra5, D. Kranich1, D. Kranich12, M. Laatiaoui5, A. Laille12, T. Lenisa7, P. Liebing5, Elina Lindfors, S. Lombardi6, Francesco Longo14, Josue J. Lopez, M. López2, E. Lorenz5, F. Lucarelli2, P. Majumdar5, G. Maneva, K. Mannheim1, Oriana Mansutti7, Mosè Mariotti6, M. I. Martínez, K. Mase5, Daniel Mazin5, C. Merck5, Mario Meucci11, M. Meyer1, Jose Miguel Miranda2, R. Mirzoyan5, S. Mizobuchi5, Abelardo Moralejo, K. Nilsson, E. Oña-Wilhelmi, R. Orduña3, N. Otte5, I. Oya2, David Paneque5, Riccardo Paoletti11, Josep M. Paredes9, M. Pasanen, D. Pascoli6, F. Pauss, N. Pavel13, R. Pegna11, Massimo Persic, L. Peruzzo6, A. Piccioli11, M. Poller1, Guy G. Pooley15, Elisa Prandini6, A. Raymers10, Wolfgang Rhode4, Marc Ribó9, J. Rico, B. Riegel1, M. Rissi, A. Robert3, Gustavo E. Romero16, S. Rügamer1, A. Saggion6, Alvaro Sanchez3, P. Sartori6, V. Scalzotto6, V. Scapin6, R. Schmitt1, T. Schweizer13, M. Shayduk13, K. Shinozaki5, Steven N. Shore17, N. Sidro, A. Sillanpää, Dorota Sobczyńska8, Antonio Stamerra11, L. S. Stark, L. O. Takalo, Petar Temnikov, D. Tescaro, Masahiro Teshima5, N. Tonello5, A. Torres3, Diego F. Torres18, Nicola Turini11, H. Vankov, V. Vitale7, Robert Wagner5, Tadeusz Wibig8, W. Wittek5, R. Zanin6, J. Zapatero3 
23 Jun 2006-Science
TL;DR: The detection of variable gamma-ray emission above 100 gigaelectron volts from the microquasar LS I 61 + 303 is reported, which suggests that the emission is periodic.
Abstract: Microquasars are binary star systems with relativistic radio-emitting jets. They are potential sources of cosmic rays and can be used to elucidate the physics of relativistic jets. We report the detection of variable gamma-ray emission above 100 gigaelectron volts from the microquasar LS I 61 + 303. Six orbital cycles were recorded. Several detections occur at a similar orbital phase, which suggests that the emission is periodic. The strongest gamma-ray emission is not observed when the two stars are closest to one another, implying a strong orbital modulation of the emission or absorption processes.

433 citations

Journal ArticleDOI
01 Apr 2003-Diabetes
TL;DR: The data suggest a transcriptional mechanism leading to decreased adiponectin plasma levels in obese women and demonstrate that low levels of adiponECTin are associated with higher levels of hs-CRP and IL-6, two inflammatory mediators and markers of increased cardiovascular risk.
Abstract: Low plasma levels of the anti-inflammatory factor adiponectin characterize obesity and insulin resistance. To elucidate the relationship between plasma levels of adiponectin, adiponectin gene expression in adipose tissue, and markers of inflammation, we obtained blood samples, anthropometric measures, and subcutaneous adipose tissue samples from 65 postmenopausal healthy women. Adiponectin plasma levels and adipose-tissue gene expression were significantly lower in obese subjects and inversely correlated with obesity-associated variables, including high-sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6). Despite adjustment for obesity-associated variables, plasma levels of adiponectin were significantly correlated to adiponectin gene expression (partial r = 0.38, P < 0.05). Furthermore, the inverse correlation between plasma levels of hs-CRP and plasma adiponectin remained significant despite correction for obesity-associated variables (partial r = -0.32, P < 0.05), whereas the inverse correlation between adiponectin plasma levels or adiponectin gene expression in adipose tissue with plasma IL-6 were largely dependent on the clustering of obesity-associated variables. In conclusion, our data suggest a transcriptional mechanism leading to decreased adiponectin plasma levels in obese women and demonstrate that low levels of adiponectin are associated with higher levels of hs-CRP and IL-6, two inflammatory mediators and markers of increased cardiovascular risk.

432 citations

Journal ArticleDOI
TL;DR: It is demonstrated that G SDMD is activated in neutrophils, during the generation of neutrophil extracellular traps (NETs), and proposed that GSDMD also plays an essential function in NETosis.
Abstract: The death of a cell is an inevitable part of its biology. During homeostasis, most cells die through apoptosis. If homeostasis is disturbed, cell death can switch to proinflammatory forms of death, such as necroptosis, pyroptosis, or NETosis. We demonstrate that the formation of neutrophil extracellular traps (NETs), a special form of neutrophil cell death that releases chromatin structures to the extracellular space, is dependent on gasdermin D (GSDMD). GSDMD is a pore-forming protein and an executor of pyroptosis. We screened a chemical library and found a small molecule based on the pyrazolo-oxazepine scaffold that efficiently blocks NET formation and GSDMD-mediated pyroptotic cell death in human cells. During NETosis, GSDMD is proteolytically activated by neutrophil proteases and, in turn, affects protease activation and nuclear expansion in a feed-forward loop. In addition to the central role of GSDMD in pyroptosis, we propose that GSDMD also plays an essential function in NETosis.

431 citations

Journal ArticleDOI
13 Sep 2001-Neuron
TL;DR: In this article, it was shown that axons of hippocampal principal cells are electrically coupled, with prepotentials or spikelets forming the physiological substrate of electrical coupling as observed in cell somata.

431 citations

Journal ArticleDOI
TL;DR: In patients with reperfused MI, CMR visualizes both reversible and irreversible injury, which allows for quantifying the extent of the salvaged area after revascularization as an important parameter for clinical decision-making and research.

431 citations


Authors

Showing all 34115 results

NameH-indexPapersCitations
Karl J. Friston2171267217169
Peer Bork206697245427
Raymond J. Dolan196919138540
Stefan Schreiber1781233138528
Andreas Pfeiffer1491756131080
Thomas Hebbeker1481984114004
Thomas Lohse1481237101631
Jean Bousquet145128896769
Hermann Kolanoski145127996152
Josh Moss139101989255
R. D. Kass1381920107907
W. Kozanecki138149899758
U. Mallik137162597439
C. Haber135150798014
Christophe Royon134145390249
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023208
2022747
20214,727
20204,083
20193,579
20183,143