Institution
Icahn School of Medicine at Mount Sinai
Education•New York, New York, United States•
About: Icahn School of Medicine at Mount Sinai is a education organization based out in New York, New York, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 37488 authors who have published 76057 publications receiving 3704104 citations. The organization is also known as: Mount Sinai School of Medicine.
Topics: Population, Cancer, Transplantation, Virus, Health care
Papers published on a yearly basis
Papers
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TL;DR: Recommendations for the establishment and operation of primary stroke centers are developed as an approach to improve the medical care of patients with stroke and suggest that several elements of a stroke center would improve patient care and outcomes.
Abstract: ObjectiveTo develop recommendations for the establishment and operation of primary
stroke centers as an approach to improve the medical care of patients with
stroke.ParticipantsMembers of the Brain Attack Coalition (BAC), a multidisciplinary group
of representatives from major professional organizations involved with delivering
stroke care. Supplemental input was obtained from other experts involved in
acute stroke care.EvidenceA review of literature published from 1966 to March 2000 was performed
using MEDLINE. More than 600 English-language articles that had evidence from
randomized clinical trials, meta-analyses, care guidelines, or other appropriate
methods supporting specific care recommendations for patients with acute stroke
that could be incorporated into a stroke center model were selected.Consensus ProcessArticles were reviewed initially by 1 author (M.J.A.). Members of the
BAC reviewed each recommendation in the context of current practice parameters,
with special attention to improving the delivery of care to patients with
acute stroke, cost-effectiveness, and logistical issues related to the establishment
of primary stroke centers. Consensus was reached among all BAC participants
before an element was added to the list of recommendations.ConclusionsRandomized clinical trials and observational studies suggest that several
elements of a stroke center would improve patient care and outcomes. Key elements
of primary stroke centers include acute stroke teams, stroke units, written
care protocols, and an integrated emergency response system. Important support
services include availability and interpretation of computed tomography scans
24 hours everyday and rapid laboratory testing. Administrative support, strong
leadership, and continuing education are also important elements for stroke
centers. Adoption of these recommendations may increase the use of appropriate
diagnostic and therapeutic modalities and reduce peristroke complications.
The establishment of primary stroke centers has the potential to improve the
care of patients with stroke.
725 citations
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TL;DR: Data indicate that aminoacridines, as a class of compounds, have a statistically significant effect to diminish, slightly, some of the cognitive symptoms of Alzheimer's Disease, and encourage the use of drugs that will reverse multiple neurotransmitter deficits.
724 citations
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TL;DR: Different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis, and studies with FGFs and their specific inhibitors showed that FGF8 contributes to the morphogenetic outgrowth of the hepatic endoderm.
Abstract: The signaling molecules that elicit embryonic induction of the liver from the mammalian gut endoderm or induction of other gut-derived organs are unknown. Close proximity of cardiac mesoderm, which expresses fibroblast growth factors (FGFs) 1, 2, and 8, causes the foregut endoderm to develop into the liver. Treatment of isolated foregut endoderm from mouse embryos with FGF1 or FGF2, but not FGF8, was sufficient to replace cardiac mesoderm as an inducer of the liver gene expression program, the latter being the first step of hepatogenesis. The hepatogenic response was restricted to endoderm tissue, which selectively coexpresses FGF receptors 1 and 4. Further studies with FGFs and their specific inhibitors showed that FGF8 contributes to the morphogenetic outgrowth of the hepatic endoderm. Thus, different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis.
724 citations
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TL;DR: A quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells reveals dramatic rewiring of phosphorylation on host and viral proteins, revealing potential COVID-19 therapies.
723 citations
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TL;DR: Treatment with subcutaneous golimumab induces clinical response, remission, and mucosal healing, and increases quality of life in larger percentages of patients with active UC than placebo.
722 citations
Authors
Showing all 37948 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert Langer | 281 | 2324 | 326306 |
Shizuo Akira | 261 | 1308 | 320561 |
Gordon H. Guyatt | 231 | 1620 | 228631 |
Eugene Braunwald | 230 | 1711 | 264576 |
Bruce S. McEwen | 215 | 1163 | 200638 |
Robert J. Lefkowitz | 214 | 860 | 147995 |
Peter Libby | 211 | 932 | 182724 |
Mark J. Daly | 204 | 763 | 304452 |
Stuart H. Orkin | 186 | 715 | 112182 |
Paul G. Richardson | 183 | 1533 | 155912 |
Alan C. Evans | 183 | 866 | 134642 |
John C. Morris | 183 | 1441 | 168413 |
Paul M. Thompson | 183 | 2271 | 146736 |
Tadamitsu Kishimoto | 181 | 1067 | 130860 |
Bruce M. Psaty | 181 | 1205 | 138244 |