Institution
Icahn School of Medicine at Mount Sinai
Education•New York, New York, United States•
About: Icahn School of Medicine at Mount Sinai is a education organization based out in New York, New York, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 37488 authors who have published 76057 publications receiving 3704104 citations. The organization is also known as: Mount Sinai School of Medicine.
Topics: Population, Cancer, Transplantation, Virus, Health care
Papers published on a yearly basis
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Icahn School of Medicine at Mount Sinai1, Pompeu Fabra University2, Autonomous University of Barcelona3, Cornell University4, Harvard University5, University of Barcelona6, Université libre de Bruxelles7, Emory University8, Children's Institute Inc.9, Boston Children's Hospital10, University of Brescia11, University of Freiburg12, University of Paris13
TL;DR: Neutrophils around the marginal zone (MZ) of the spleen, a B cell area specialized in T cell–independent immunoglobulin responses to circulating antigen, are identified, which indicates that neutrophils generate an innate layer of antimicrobial immunoglOBulin defense by interacting with MZ B cells.
Abstract: Follicular T cells provide help to B cells to elicit antibody responses. Cerutti and colleagues show that neutrophils provide help to marginal-zone B cells that produce T cell–independent antibodies.
643 citations
TL;DR: Whereas human and mouse monocyte subsets are far more broadly conserved than currently recognized, important differences between the species deserve consideration when models of human disease are studied in mice.
642 citations
Katholieke Universiteit Leuven1, Beth Israel Medical Center2, French Institute of Health and Medical Research3, Columbia University4, University of Melbourne5, Saint Louis University6, University of Florida7, University of Birmingham8, Boston Children's Hospital9, Cedars-Sinai Medical Center10, University of Groningen11, University of Cambridge12, Kurume University13, Kanazawa University14, University of Western Australia15, Yonsei University16, Indiana University17, Royal Free Hospital18, Icahn School of Medicine at Mount Sinai19, Toronto General Hospital20, New York University21
TL;DR: This international group of liver pathologists and hepatologists seeks to arrive at a consensus on nomenclature for normal human livers and human reactive lesions that can facilitate more rapid advancement of the field.
642 citations
TL;DR: The cosegregation of two related genes with two related syndromes implies that fibrillin mutations are likely to be responsible for different MFS phenotypes.
Abstract: Marfan syndrome (MFS), one of the most common genetic disorders of connective tissue, is characterized by skeletal, cardiovascular and ocular abnormalities. The incidence of the disease is about 1 in 20,000, with life expectancy severely reduced because of cardiovascular complications. As the underlying defect is unknown, MFS diagnosis is based solely on clinical criteria. Certain phenotypic features of MFS are also shared by other conditions, which may be genetically distinct entities although part of a clinical continuum. Immunohistochemical studies have implicated fibrillin, a major component of elastin-associated microfibrils, in MFS aetiology. Genetic linkage analysis with random probes has independently localized the MFS locus to chromosome 15. Here we report that these two experimental approaches converge with the cloning and mapping of the fibrillin gene to chromosome 15q15-21, and with the establishment of linkage to MFS. We also isolated a second fibrillin gene and mapped it to chromosome 5q23-31. We linked this novel gene to a condition, congenital contractural arachnodactyly, that shares some of the features of MFS. Thus, the cosegregation of two related genes with two related syndromes implies that fibrillin mutations are likely to be responsible for different MFS phenotypes.
641 citations
Nicholas J Kassebaum1, Ryan M Barber1, Zulfiqar A Bhutta2, Zulfiqar A Bhutta3 +613 more•Institutions (272)
TL;DR: In this article, the authors quantified maternal mortality throughout the world by underlying cause and age from 1990 to 2015 for ages 10-54 years by systematically compiling and processing all available data sources from 186 of 195 countries and territories.
641 citations
Authors
Showing all 37948 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Robert Langer | 281 | 2324 | 326306 |
| Shizuo Akira | 261 | 1308 | 320561 |
| Gordon H. Guyatt | 231 | 1620 | 228631 |
| Eugene Braunwald | 230 | 1711 | 264576 |
| Bruce S. McEwen | 215 | 1163 | 200638 |
| Robert J. Lefkowitz | 214 | 860 | 147995 |
| Peter Libby | 211 | 932 | 182724 |
| Mark J. Daly | 204 | 763 | 304452 |
| Stuart H. Orkin | 186 | 715 | 112182 |
| Paul G. Richardson | 183 | 1533 | 155912 |
| Alan C. Evans | 183 | 866 | 134642 |
| John C. Morris | 183 | 1441 | 168413 |
| Paul M. Thompson | 183 | 2271 | 146736 |
| Tadamitsu Kishimoto | 181 | 1067 | 130860 |
| Bruce M. Psaty | 181 | 1205 | 138244 |