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Institution

Icahn School of Medicine at Mount Sinai

EducationNew York, New York, United States
About: Icahn School of Medicine at Mount Sinai is a education organization based out in New York, New York, United States. It is known for research contribution in the topics: Population & Cancer. The organization has 37488 authors who have published 76057 publications receiving 3704104 citations. The organization is also known as: Mount Sinai School of Medicine.


Papers
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Journal ArticleDOI
TL;DR: It has been determined that SARS-CoV open reading frame (ORF) 3b, ORF 6, and N proteins antagonize interferon, a key component of the innate immune response.
Abstract: The severe acute respiratory syndrome coronavirus (SARS-CoV) is highly pathogenic in humans, with a death rate near 10%. This high pathogenicity suggests that SARS-CoV has developed mechanisms to overcome the host innate immune response. It has now been determined that SARS-CoV open reading frame (ORF) 3b, ORF 6, and N proteins antagonize interferon, a key component of the innate immune response. All three proteins inhibit the expression of beta interferon (IFN-beta), and further examination revealed that these SARS-CoV proteins inhibit a key protein necessary for the expression of IFN-beta, IRF-3. N protein dramatically inhibited expression from an NF-kappaB-responsive promoter. All three proteins were able to inhibit expression from an interferon-stimulated response element (ISRE) promoter after infection with Sendai virus, while only ORF 3b and ORF 6 proteins were able to inhibit expression from the ISRE promoter after treatment with interferon. This indicates that N protein inhibits only the synthesis of interferon, while ORF 3b and ORF 6 proteins inhibit both interferon synthesis and signaling. ORF 6 protein, but not ORF 3b or N protein, inhibited nuclear translocation but not phosphorylation of STAT1. Thus, it appears that these three interferon antagonists of SARS-CoV inhibit the interferon response by different mechanisms.

628 citations

Journal ArticleDOI
Roby Joehanes, Allan C. Just1, Riccardo E. Marioni2, Luke C. Pilling1, Lindsay M. Reynolds1, Pooja R. Mandaviya3, Weihua Guan, Tao Xu2, Cathy E. Elks2, Stella Aslibekyan1, Hortensia Moreno-Macías4, Jennifer A. Smith3, Jennifer A. Brody3, Radhika Dhingra3, Paul Yousefi5, James S. Pankow, Sonja Kunze, Sonia Shah6, Allan F. McRae6, Kurt Lohman6, Jin Sha7, Jin Sha8, Devin Absher8, Luigi Ferrucci8, Wei Zhao9, Ellen W. Demerath7, Jan Bressler6, Megan L. Grove8, Tianxiao Huan9, Tianxiao Huan10, Chunyu Liu5, Chunyu Liu2, Chunyu Liu3, Michael M. Mendelson, Chen Yao1, Douglas P. Kiel4, Annette Peters11, Rui Wang-Sattler, Peter M. Visscher12, Naomi R. Wray, John M. Starr13, Jingzhong Ding3, Carlos J. Rodriguez1, Nicholas J. Wareham, Marguerite R. Irvin2, Degui Zhi2, Myrto Barrdahl2, Paolo Vineis1, Srikant Ambatipudi, André G. Uitterlinden2, Albert Hofman14, Joel Schwartz10, Elena Colicino15, Lifang Hou3, Pantel S. Vokonas2, D. Hernandez16, Andrew B. Singleton, Stefania Bandinelli17, Stephen Turner, Erin B. Ware, Alicia K. Smith, Torsten Klengel18, Elisabeth B. Binder19, Bruce M. Psaty20, Kent D. Taylor, Sina A. Gharib1, Brenton R. Swenson21, Liming Liang22, Dawn L. DeMeo, George T. O'Connor, Zdenko Herceg1, Kerry J. Ressler23, Karen N. Conneely11, N. Sotoodehnia24, Sharon L.R. Kardia2, David Melzer17, Andrea A. Baccarelli1, Joyce B. J. van Meurs1, Isabelle Romieu3, Donna K. Arnett, Ken K. Ong, Yongmei Liu19, M. Waldenberger25, Ian J. Deary1, Myriam Fornage26, Daniel Levy, Stephanie J. London11 
TL;DR: Cigarette smoking has a broad impact on genome-wide methylation that, at many loci, persists many years aftersmoking cessation, indicating a pattern of persistent altered methylation, with attenuation, after smoking cessation.
Abstract: Background —DNA methylation leaves a long-term signature of smoking exposure and is one potential mechanism by which tobacco exposure predisposes to adverse health outcomes, such as cancers, osteoporosis, lung, and cardiovascular disorders. Methods and Results —To comprehensively determine the association between cigarette smoking and DNA methylation, we conducted a meta-analysis of genome-wide DNA methylation assessed using the Illumina BeadChip 450K array on 15,907 blood derived DNA samples from participants in 16 cohorts (including 2,433 current, 6,518 former, and 6,956 never smokers). Comparing current versus never smokers, 2,623 CpG sites (CpGs), annotated to 1,405 genes, were statistically significantly differentially methylated at Bonferroni threshold of p<1×10-7 (18,760 CpGs at False Discovery Rate (FDR)<0.05). Genes annotated to these CpGs were enriched for associations with several smoking-related traits in genome-wide studies including pulmonary function, cancers, inflammatory diseases and heart disease. Comparing former versus never smokers, 185 of the CpGs that differed between current and never smokers were significant p<1×10-7 (2,623 CpGs at FDR<0.05), indicating a pattern of persistent altered methylation, with attenuation, after smoking cessation. Transcriptomic integration identified effects on gene expression at many differentially methylated CpGs. Conclusions —Cigarette smoking has a broad impact on genome-wide methylation that, at many loci, persists many years after smoking cessation. Many of the differentially methylated genes were novel genes with respect to biologic effects of smoking, and might represent therapeutic targets for prevention or treatment of tobacco-related diseases. Methylation at these sites could also serve as sensitive and stable biomarkers of lifetime exposure to tobacco smoke.

628 citations

Journal ArticleDOI
TL;DR: Among high-risk patients who underwent PCI and completed 3 months of dual antiplatelet therapy, ticagrelor monotherapy was associated with a lower incidence of clinically relevant bleeding than ticagerelor plus aspirin, with no higher risk of death, myocardial infarction, or stroke.
Abstract: Background Monotherapy with a P2Y12 inhibitor after a minimum period of dual antiplatelet therapy is an emerging approach to reduce the risk of bleeding after percutaneous coronary interve...

626 citations

Journal ArticleDOI
TL;DR: A comprehensive molecular portrait of genomic changes in progressive HCV‐related HCC is provided, using quantitative real‐time reverse‐transcription PCR to identify new biomarkers for early HCC diagnosis.

626 citations

Journal ArticleDOI
TL;DR: A transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens is identified and predicted regulators of DC functional diversity in tissues are predicted.
Abstract: Although much progress has been made in the understanding of the ontogeny and function of dendritic cells (DCs), the transcriptional regulation of the lineage commitment and functional specialization of DCs in vivo remains poorly understood. We made a comprehensive comparative analysis of CD8 + , CD103 + , CD11b + and plasmacytoid DC subsets, as well as macrophage DC precursors and common DC precursors, across the entire immune system. Here we characterized candidate transcriptional activators involved in the commitment of myeloid progenitor cells to the DC lineage and predicted regulators of DC functional diversity in tissues. We identified a molecular signature that distinguished tissue DCs from macrophages. We also identified a transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens.

626 citations


Authors

Showing all 37948 results

NameH-indexPapersCitations
Robert Langer2812324326306
Shizuo Akira2611308320561
Gordon H. Guyatt2311620228631
Eugene Braunwald2301711264576
Bruce S. McEwen2151163200638
Robert J. Lefkowitz214860147995
Peter Libby211932182724
Mark J. Daly204763304452
Stuart H. Orkin186715112182
Paul G. Richardson1831533155912
Alan C. Evans183866134642
John C. Morris1831441168413
Paul M. Thompson1832271146736
Tadamitsu Kishimoto1811067130860
Bruce M. Psaty1811205138244
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023157
2022844
20217,117
20206,224
20195,200
20184,505