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ICM Partners

About: ICM Partners is a based out in . It is known for research contribution in the topics: Population & Breast cancer. The organization has 1311 authors who have published 1521 publications receiving 33745 citations. The organization is also known as: International Creative Management Partners.


Papers
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Journal ArticleDOI
Serena Nik-Zainal1, Serena Nik-Zainal2, Helen Davies1, Johan Staaf3, Manasa Ramakrishna1, Dominik Glodzik1, Xueqing Zou1, Inigo Martincorena1, Ludmil B. Alexandrov1, Sancha Martin1, David C. Wedge1, Peter Van Loo1, Young Seok Ju1, Michiel M. Smid4, Arie B. Brinkman5, Sandro Morganella6, Miriam Ragle Aure7, Ole Christian Lingjærde7, Anita Langerød8, Markus Ringnér3, Sung-Min Ahn9, Sandrine Boyault, Jane E. Brock, Annegien Broeks10, Adam Butler1, Christine Desmedt11, Luc Dirix12, Serge Dronov1, Aquila Fatima13, John A. Foekens4, Moritz Gerstung1, Gerrit Gk Hooijer14, Se Jin Jang15, David Jones1, Hyung-Yong Kim16, Tari Ta King17, Savitri Krishnamurthy18, Hee Jin Lee15, Jeong-Yeon Lee16, Yang Li1, Stuart McLaren1, Andrew Menzies1, Ville Mustonen1, Sarah O’Meara1, Iris Pauporté, Xavier Pivot19, Colin Ca Purdie20, Keiran Raine1, Kamna Ramakrishnan1, Germán Fg Rodríguez-González4, Gilles Romieu21, Anieta M. Sieuwerts4, Peter Pt Simpson22, Rebecca Shepherd1, Lucy Stebbings1, Olafur Oa Stefansson23, Jon W. Teague1, Stefania Tommasi, Isabelle Treilleux, Gert Van den Eynden12, Peter B. Vermeulen12, Anne Vincent-Salomon24, Lucy R. Yates1, Carlos Caldas25, Laura Van't Veer10, Andrew Tutt26, Andrew Tutt27, Stian Knappskog28, Benita Kiat Tee Bk Tan29, Jos Jonkers10, Åke Borg3, Naoto T. Ueno18, Christos Sotiriou11, Alain Viari, P. Andrew Futreal1, Peter J. Campbell1, Paul N. Span5, Steven Van Laere12, Sunil R. Lakhani22, Jorunn E. Eyfjord23, Alastair M Thompson, Ewan Birney6, Hendrik G. Stunnenberg5, Marc J. van de Vijver14, John W.M. Martens4, Anne Lise Børresen-Dale8, Andrea L. Richardson13, Gu Kong16, Gilles Thomas, Michael R. Stratton1 
02 Jun 2016-Nature
TL;DR: This analysis of all classes of somatic mutation across exons, introns and intergenic regions highlights the repertoire of cancer genes and mutational processes operative, and progresses towards a comprehensive account of the somatic genetic basis of breast cancer.
Abstract: We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding cancer genes carried probable driver mutations. Some non-coding regions exhibited high mutation frequencies, but most have distinctive structural features probably causing elevated mutation rates and do not contain driver mutations. Mutational signature analysis was extended to genome rearrangements and revealed twelve base substitution and six rearrangement signatures. Three rearrangement signatures, characterized by tandem duplications or deletions, appear associated with defective homologous-recombination-based DNA repair: one with deficient BRCA1 function, another with deficient BRCA1 or BRCA2 function, the cause of the third is unknown. This analysis of all classes of somatic mutation across exons, introns and intergenic regions highlights the repertoire of cancer genes and mutational processes operating, and progresses towards a comprehensive account of the somatic genetic basis of breast cancer.

1,696 citations

Journal ArticleDOI
Andrew I R Maas1, David K. Menon2, P. David Adelson3, Nada Andelic4  +339 moreInstitutions (110)
TL;DR: The InTBIR Participants and Investigators have provided informed consent for the study to take place in Poland.
Abstract: Additional co-authors: Endre Czeiter, Marek Czosnyka, Ramon Diaz-Arrastia, Jens P Dreier, Ann-Christine Duhaime, Ari Ercole, Thomas A van Essen, Valery L Feigin, Guoyi Gao, Joseph Giacino, Laura E Gonzalez-Lara, Russell L Gruen, Deepak Gupta, Jed A Hartings, Sean Hill, Ji-yao Jiang, Naomi Ketharanathan, Erwin J O Kompanje, Linda Lanyon, Steven Laureys, Fiona Lecky, Harvey Levin, Hester F Lingsma, Marc Maegele, Marek Majdan, Geoffrey Manley, Jill Marsteller, Luciana Mascia, Charles McFadyen, Stefania Mondello, Virginia Newcombe, Aarno Palotie, Paul M Parizel, Wilco Peul, James Piercy, Suzanne Polinder, Louis Puybasset, Todd E Rasmussen, Rolf Rossaint, Peter Smielewski, Jeannette Soderberg, Simon J Stanworth, Murray B Stein, Nicole von Steinbuchel, William Stewart, Ewout W Steyerberg, Nino Stocchetti, Anneliese Synnot, Braden Te Ao, Olli Tenovuo, Alice Theadom, Dick Tibboel, Walter Videtta, Kevin K W Wang, W Huw Williams, Kristine Yaffe for the InTBIR Participants and Investigators

1,354 citations

Journal ArticleDOI
TL;DR: An updated review of the literature and evidence on the definitions and lexicon, the limits, the natural history, the markers of progression, and the ethical consequence of detecting the disease at this asymptomatic stage of Alzheimer's disease are provided.
Abstract: During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker research and substantial discoveries, it is now possible to identify the disease even at the preclinical stage before the occurrence of the first clinical symptoms. This preclinical stage of AD has become a major research focus as the field postulates that early intervention may offer the best chance of therapeutic success. To date, very little evidence is established on this "silent" stage of the disease. A clarification is needed about the definitions and lexicon, the limits, the natural history, the markers of progression, and the ethical consequence of detecting the disease at this asymptomatic stage. This article is aimed at addressing all the different issues by providing for each of them an updated review of the literature and evidence, with practical recommendations.

1,235 citations

Journal ArticleDOI
TL;DR: It is argued that existing evidence is sufficiently strong to warrant engineering controls targeting airborne transmission as part of an overall strategy to limit infection risk indoors, and that the use of engineering controls in public buildings would be an additional important measure globally to reduce the likelihood of transmission.

924 citations

Journal ArticleDOI
TL;DR: In patients with Parkinson's disease the loss of dopamine is predominantly in the posterior putamen, a region of the basal ganglia associated with the control of habitual behaviour, and patients may be forced into a progressive reliance on the goal-directed mode of action control that is mediated by comparatively preserved processing in the rostromedial striatum.
Abstract: Progressive loss of the ascending dopaminergic projection in the basal ganglia is a fundamental pathological feature of Parkinson's disease. Studies in animals and humans have identified spatially segregated functional territories in the basal ganglia for the control of goal-directed and habitual actions. In patients with Parkinson's disease the loss of dopamine is predominantly in the posterior putamen, a region of the basal ganglia associated with the control of habitual behaviour. These patients may therefore be forced into a progressive reliance on the goal-directed mode of action control that is mediated by comparatively preserved processing in the rostromedial striatum. Thus, many of their behavioural difficulties may reflect a loss of normal automatic control owing to distorting output signals from habitual control circuits, which impede the expression of goal-directed action.

914 citations


Authors

Showing all 1311 results

NameH-indexPapersCitations
Alexis Brice13587083466
Bruno Dubois12464678784
Harald Hampel10960165160
Alexandra Durr10459447018
Laurent D. Cohen9441742709
Jürgen Eckert92136842119
Stéphane Lehéricy8933227214
Antoine Danchin8048330219
Marie Vidailhet7939121836
Josep M. Gasol7731322638
Mélanie Boly7623221552
Etienne C. Hirsch7521822591
Måns Ehrenberg7423417637
Elizabeth M. C. Fisher7429821150
Isabelle Arnulf7333118456
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20223
2021141
2020171
2019167
2018160
2017172