Institution
Imperial College Healthcare
Healthcare•London, England, United Kingdom•
About: Imperial College Healthcare is a healthcare organization based out in London, England, United Kingdom. It is known for research contribution in the topics: Population & Intensive care. The organization has 5984 authors who have published 7565 publications receiving 183414 citations.
Papers published on a yearly basis
Papers
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TL;DR: Implementation of the checklist was associated with concomitant reductions in the rates of death and complications among patients at least 16 years of age who were undergoing noncardiac surgery in a diverse group of hospitals.
Abstract: The rate of death was 1.5% before the checklist was introduced and declined to 0.8% afterward (P = 0.003). Inpatient complications occurred in 11.0% of patients at baseline and in 7.0% after introduction of the checklist (P<0.001). Conclusions Implementation of the checklist was associated with concomitant reductions in the rates of death and complications among patients at least 16 years of age who were undergoing noncardiac surgery in a diverse group of hospitals.
4,764 citations
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TL;DR: The socio-economic effects of COVID-19 on individual aspects of the world economy are summarised to show the need for medical supplies has significantly increased and the food sector has seen a great demand due to panic-buying and stockpiling of food products.
4,060 citations
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Katholieke Universiteit Leuven1, University of Valencia2, Radboud University Nijmegen3, Sheba Medical Center4, University of Turin5, Hospital Clínico San Carlos6, Université Paris-Saclay7, University of Pisa8, Mayo Clinic9, University of São Paulo10, The Chinese University of Hong Kong11, University of Oxford12, University of Helsinki13, Helsinki University Central Hospital14, Institute of Cancer Research15, Bank of Cyprus16, University of Ioannina17, Odense University Hospital18, University of Amsterdam19, Otto-von-Guericke University Magdeburg20, Geneva College21, Medical University of Vienna22, Martin Luther University of Halle-Wittenberg23, Hebron University24, Imperial College Healthcare25
TL;DR: These ESMO consensus guidelines have been developed based on the current available evidence to provide a series of evidence-based recommendations to assist in the treatment and management of patients with mCRC in this rapidly evolving treatment setting.
2,382 citations
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TL;DR: A hitherto underappreciated role of type I IFN-αβ signalling in the pathogenesis of TB is demonstrated, which has implications for vaccine and therapeutic development and a broad range of transcriptional biomarkers with potential as diagnostic and prognostic tools to combat the TB epidemic are provided.
Abstract: Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with diagnosis, prevention and treatment. Most people infected with M. tuberculosis remain asymptomatic, termed latent TB, with a 10% lifetime risk of developing active TB disease. Current tests, however, cannot identify which individuals will develop disease. The immune response to M. tuberculosis is complex and incompletely characterized, hindering development of new diagnostics, therapies and vaccines. Here we identify a whole-blood 393 transcript signature for active TB in intermediate and high-burden settings, correlating with radiological extent of disease and reverting to that of healthy controls after treatment. A subset of patients with latent TB had signatures similar to those in patients with active TB. We also identify a specific 86-transcript signature that discriminates active TB from other inflammatory and infectious diseases. Modular and pathway analysis revealed that the TB signature was dominated by a neutrophil-driven interferon (IFN)-inducible gene profile, consisting of both IFN-gamma and type I IFN-alphabeta signalling. Comparison with transcriptional signatures in purified cells and flow cytometric analysis suggest that this TB signature reflects changes in cellular composition and altered gene expression. Although an IFN-inducible signature was also observed in whole blood of patients with systemic lupus erythematosus (SLE), their complete modular signature differed from TB, with increased abundance of plasma cell transcripts. Our studies demonstrate a hitherto underappreciated role of type I IFN-alphabeta signalling in the pathogenesis of TB, which has implications for vaccine and therapeutic development. Our study also provides a broad range of transcriptional biomarkers with potential as diagnostic and prognostic tools to combat the TB epidemic.
1,588 citations
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Chelsea and Westminster Hospital NHS Foundation Trust1, Public Health England2, Central and North West London NHS Foundation Trust3, University College London4, Brighton and Sussex University Hospitals NHS Trust5, Central Manchester University Hospitals NHS Foundation Trust6, Imperial College Healthcare7, Hull York Medical School8, Barts Health NHS Trust9, University of Cambridge10, Guy's and St Thomas' NHS Foundation Trust11, Heart of England NHS Foundation Trust12, University of Liverpool13
TL;DR: In this high incidence population, daily tenofovir–emtricitabine conferred even higher protection against HIV than in placebo-controlled trials, refuting concerns that effectiveness would be less in a real-world setting.
1,472 citations
Authors
Showing all 6027 results
Name | H-index | Papers | Citations |
---|---|---|---|
Nicholas G. Martin | 192 | 1770 | 161952 |
Elio Riboli | 158 | 1136 | 110499 |
Paul Elliott | 153 | 773 | 103839 |
Timothy P. Hughes | 145 | 831 | 91357 |
Paul M. Matthews | 140 | 617 | 88802 |
David A. Jackson | 136 | 1095 | 68352 |
Torben Jørgensen | 135 | 883 | 86822 |
Stephen R. Bloom | 134 | 747 | 71493 |
Majid Ezzati | 133 | 443 | 137171 |
Ara Darzi | 123 | 1613 | 64907 |
John C. Chambers | 122 | 645 | 71028 |
Gareth J. Barker | 122 | 800 | 54466 |
Francesco Muntoni | 115 | 963 | 52629 |
Paul Turner | 114 | 1099 | 61390 |
Paul J. Martin | 113 | 818 | 59882 |