Indian Institute of Technology Bombay

About: Indian Institute of Technology Bombay is a education organization based out in Mumbai, India. It is known for research contribution in the topics: Population & Thin film. The organization has 16756 authors who have published 33588 publications receiving 570559 citations.

Longitudinal double-spin asymmetry and cross section for inclusive jet production in polarized proton collisions at s=200GeV

Abstract: We report a measurement of the longitudinal double-spin asymmetry A(LL) and the differential cross section for inclusive midrapidity jet production in polarized proton collisions at s=200 GeV. The cross section data cover transverse momenta 5 < p(T)< 50 GeV/c and agree with next-to-leading order perturbative QCD evaluations. The A(LL) data cover 5 < p(T)< 17 GeV/c and disfavor at 98% C.L. maximal positive gluon polarization in the polarized nucleon.

A Global Snapshot of Computer Science Education in K-12 Schools

Abstract: In two special issues of the ACM journal "Transactions on Computing Education" (TOCE), 14 extensive case studies about the various situations of Computer Science Education (CSE) in K-12 schools in 12 countries (respectively states) were collected. During the work at the ITiCSE 2015, we have performed a deductive qualitative text analysis on these case studies in order to extract the most useful information. As a category system, we applied some selected categories of the Darmstadt Model that was developed by the working group "Computer Science/Informatics in Secondary Schools" at the ITiCSE 2011. Based on the coding results, we summarized information about the different fields of Computing Education at schools, the intended goals and competencies, the taught content, the applied programming languages and tools and the different forms of assessment and teacher education. Despite the limitations of the analyzed articles, representing just snapshots of complex situations from the specific viewpoint of the respective authors, we were able to collect some interesting results.

Islet-Like Cell Aggregates Generated from Human Adipose Tissue Derived Stem Cells Ameliorate Experimental Diabetes in Mice

Abstract: Background Type 1 Diabetes Mellitus is caused by auto immune destruction of insulin producing beta cells in the pancreas. Currently available treatments include transplantation of isolated islets from donor pancreas to the patient. However, this method is limited by inadequate means of immuno-suppression to prevent islet rejection and importantly, limited supply of islets for transplantation. Autologous adult stem cells are now considered for cell replacement therapy in diabetes as it has the potential to generate neo-islets which are genetically part of the treated individual. Adopting methods of islet encapsulation in immuno-isolatory devices would eliminate the need for immuno-suppressants. Methodology/Principal Findings In the present study we explore the potential of human adipose tissue derived adult stem cells (h-ASCs) to differentiate into functional islet like cell aggregates (ICAs). Our stage specific differentiation protocol permit the conversion of mesodermic h-ASCs to definitive endoderm (Hnf3β, TCF2 and Sox17) and to PDX1, Ngn3, NeuroD, Pax4 positive pancreatic endoderm which further matures in vitro to secrete insulin. These ICAs are shown to produce human C-peptide in a glucose dependent manner exhibiting in-vitro functionality. Transplantation of mature ICAs, packed in immuno-isolatory biocompatible capsules to STZ induced diabetic mice restored near normoglycemia within 3–4 weeks. The detection of human C-peptide, 1155±165 pM in blood serum of experimental mice demonstrate the efficacy of our differentiation approach. Conclusions h-ASC is an ideal population of personal stem cells for cell replacement therapy, given that they are abundant, easily available and autologous in origin. Our findings present evidence that h-ASCs could be induced to differentiate into physiologically competent functional islet like cell aggregates, which may provide as a source of alternative islets for cell replacement therapy in type 1 diabetes.