Indian Institute of Technology Bombay

About: Indian Institute of Technology Bombay is a education organization based out in Mumbai, India. It is known for research contribution in the topics: Catalysis & Computer science. The organization has 16756 authors who have published 33588 publications receiving 570559 citations.

Radial segregation of granular mixtures in rotating cylinders

Abstract: Simultaneous mixing and segregation of granular materials is of considerable practical importance; the interplay among both processes is, however, poorly understood from a fundamental viewpoint. The focus of this work is radial segregation—core formation—due to density in a rotating cylinder. The flow regime considered is the cascading or continuous flow regime where a thin layer of solids flows along a nearly flat free surface, while the remaining particles rotate as a fixed bed along with the cylinder. The essence of the formation of a central segregated core of the more dense particles lies in the flow, mixing, and segregation in the cascading layer. The work involves experiments and analysis. A constitutive model for the segregation flux in cascading layers is proposed and validated by particle dynamics and Monte Carlo simulations for steady flow down an inclined plane. The model contains a single parameter, the dimensionless segregation velocity (β), which is treated as a fitting parameter here. Expe...

Hierarchical Coded Caching

Abstract: caching of popular content during off-peak hours is a strategy to reduce network loads during peak hours. Recent work has shown significant benefits of designing such caching strategies not only to locally deliver the part of the content, but also to provide coded multicasting opportunities even among users with different demands. Exploiting both of these gains was shown to be approximately optimal for caching systems with a single layer of caches. Motivated by practical scenarios, we consider, in this paper, a hierarchical content delivery network with two layers of caches. We propose a new caching scheme that combines two basic approaches. The first approach provides coded multicasting opportunities within each layer; the second approach provides coded multicasting opportunities across multiple layers. By striking the right balance between these two approaches, we show that the proposed scheme achieves the optimal communication rates to within a constant multiplicative and additive gap. We further show that there is no tension between the rates in each of the two layers up to the aforementioned gap. Thus, both the layers can simultaneously operate at approximately the minimum rate.

Weld bead modeling and process optimization in Hybrid Layered Manufacturing

Abstract: Hybrid Layered Manufacturing is a Rapid Manufacturing process in which the metallic object is built in layers using weld deposition. Each layer built through overlapping beads is face milled to remove the scales and scallops and ensure Z-accuracy. The formations of single beads and overlapping multiple beads are modeled in this paper. While the individual bead's geometry is influenced by the size of the filler wire and the speeds of the wire and torch, the step over increment between the consecutive beads additionally comes into the picture for the multiple bead deposition. These models were validated experimentally. They are useful not only to predict the bead's shape but also to optimize the three process parameters.

Stereochemistry of actinomycin--DNA binding.

Abstract: The three dimensional structure of a crystalline complex containing actino-mycin D and deoxyguanosine has shed light on the stereochemistry of actino-mycin binding to DNA. The phenoxa-zone ring system of actinomycin intercalates into the DNA helix, while deoxyguanosine residues interact with both cyclic peptides through specific hydrogen bonds.

Palladium-catalyzed aryl C-H olefination with unactivated, aliphatic alkenes.

Abstract: Palladium-catalyzed coupling between aryl halides and alkenes (Mizoroki–Heck reaction) is one of the most popular reactions for synthesizing complex organic molecules. The limited availability, problematic synthesis, and higher cost of aryl halide precursors (or their equivalents) have encouraged exploration of direct olefination of aryl carbon–hydrogen (C–H) bonds (Fujiwara–Moritani reaction). Despite significant progress, the restricted substrate scope, in particular noncompliance of unactivated aliphatic olefins, has discouraged the use of this greener alternative. Overcoming this serious limitation, we report here a palladium-catalyzed chelation-assisted ortho C–H bond olefination of phenylacetic acid derivatives with unactivated, aliphatic alkenes in good to excellent yields with high regio- and stereoselectivities. The versatility of this operationally simple method has been demonstrated through drug diversification and sequential C–H olefination for synthesizing divinylbenzene derivatives.