Indian Institute of Technology Bombay

About: Indian Institute of Technology Bombay is a education organization based out in Mumbai, India. It is known for research contribution in the topics: Population & Thin film. The organization has 16756 authors who have published 33588 publications receiving 570559 citations.

The Parkinson's disease-associated H50Q mutation accelerates α-Synuclein aggregation in vitro.

Abstract: α-Synuclein (α-Syn) aggregation is directly linked with Parkinson’s disease (PD) pathogenesis. Here, we analyzed the aggregation of newly discovered α-Syn missense mutant H50Q in vitro and found that this mutation significantly accelerates the aggregation and amyloid formation of α-Syn. This mutation, however, did not alter the overall secondary structure as suggested by two-dimensional nuclear magnetic resonance and circular dichroism spectroscopy. The initial oligomerization study by cross-linking and chromatographic techniques suggested that this mutant oligomerizes to an extent similar to that of the wild-type α-Syn protein. Understanding the aggregation mechanism of this H50Q mutant may help to establish the aggregation and phenotypic relationship of this novel mutant in PD.

Direct observation of dijets in central Au+Au collisions at sNN=200GeV

Abstract: The STAR Collaboration at the Relativistic Heavy Ion Collider reports measurements of azimuthal correlations of high transverse momentum (p(T)) charged hadrons in Au+Au collisions at higher p(T) than reported previously. As p(T) is increased, a narrow, back-to-back peak emerges above the decreasing background, providing a clear dijet signal for all collision centralities studied. Using these correlations, we perform a systematic study of dijet production and suppression in nuclear collisions, providing new constraints on the mechanisms underlying partonic energy loss in dense matter.

Rapidity and transverse-momentum dependence of the inclusive J/psi nuclear modification factor in p-Pb collisions at root s(NN)=5.02 TeV

Abstract: We have studied the transverse-momentum (pT) dependence of the inclusive J/ψ production in p-Pb collisions at √sNN = 5.02 TeV, in three center-of-mass rapidity (ycms) regions, down to zero pT. Results in the forward and backward rapidity ranges (2.03 < ycms < 3.53 and −4.46 < ycms < −2.96) are obtained by studying the J/ψ decay to µ +µ −, while the mid-rapidity region (−1.37 < ycms < 0.43) is investigated by measuring the e+e − decay channel. The pT dependence of the J/ψ production cross section and nuclear modification factor are presented for each of the rapidity intervals, as well as the J/ψ mean pT values. Forward and mid-rapidity results show a suppression of the J/ψ yield, with respect to pp collisions, which decreases with increasing pT. At backward rapidity no significant J/ψ suppression is observed. Theoretical models including a combination of cold nuclear matter effects such as shadowing and partonic energy loss, are in fair agreement with the data, except at forward rapidity and low transverse momentum. The implications of the p-Pb results for the evaluation of cold nuclear matter effects on J/ψ production in Pb-Pb collisions are also discussed.

Minijet deformation and charge-independent angular correlations on momentum subspace (eta, phi) in Au-Au collisions at root S-NN=130 GeV

Abstract: Measurements of two-particle correlations on angular difference variables η1 − η2 (pseudorapidity) and φ1 − φ2 (azimuth) are presented for all primary charged hadrons with transverse momentum 0.15 ≤ p_t ≤ 2 GeV/c and |η| ≤ 1.3 from Au-Au collisions at √s_(NN) = 130 GeV. Large-amplitude correlations are observed over a broad range in relative angles where distinct structures appear on the same-side and away-side (i.e., relative azimuth less than π/2 or greater than π/2). The principal correlation structures include that associated with elliptic flow plus a strong, same-side peak. It is hypothesized that the latter results from correlated hadrons associated with semi-hard parton scattering in the early stage of the heavy-ion collision which produces a jet-like correlation peak at small relative angles. The width of the jet-like peak on η1 − η2 increases by a factor 2.3 from peripheral to central collisions, suggesting strong coupling of semi-hard scattered partons to a longitudinally-expanding medium. The new methods of jet analysis introduced here provide access to scattered partons at low transverse momentum well below the kinematic range where perturbative quantum chromodynamics and standard fragmentation models are applicable.