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Institution

Indian Institute of Technology Guwahati

EducationGuwahati, Assam, India
About: Indian Institute of Technology Guwahati is a education organization based out in Guwahati, Assam, India. It is known for research contribution in the topics: Adsorption & Catalysis. The organization has 6933 authors who have published 17102 publications receiving 257351 citations.


Papers
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Journal ArticleDOI
TL;DR: The developed biphasic scaffold show great promise for improving the current clinical strategies for osteochondral tissue repair, as evidenced by enhanced expression levels of key cartilage and bone specific marker genes.
Abstract: The anatomical complexity and slow regeneration capacity of hyaline cartilage at the osteochondral interface pose a great challenge in the repair of osteochondral defects (OCD). In this study, we utilized the processing feasibility offered by the sol derived 70S bioactive glass and silk fibroin (mulberry Bombyx mori and endemic Indian non-mulberry Antheraea assama), in fabricating a well-integrated, biomimetic scaffolding matrix with a coherent interface. Differences in surface properties such as wettability and amorphousness between the two silk groups resulted in profound variations in cell attachment and extracellular matrix protein deposition. Mechanical assessment showed that the biphasic composites exhibited both an elastic region pertinent for cartilage tissue and a stiff compression resistant region simulating the bone phase. In vitro biological studies revealed that the biphasic mats presented spatial confinement for the growth and maturation of both osteoblasts and chondrocytes, marked by increased alkaline phosphatase (ALP) activity, osteopontin (OPN), sulfated glycosaminoglycan (sGAG) and collagen secretion in the cocultured mats. The non-mulberry silk based biphasic composite mats performed better than their mulberry counterpart, as evidenced by enhanced expression levels of key cartilage and bone specific marker genes. Therefore, the developed biphasic scaffold show great promise for improving the current clinical strategies for osteochondral tissue repair.

83 citations

Journal ArticleDOI
TL;DR: In this paper, a year-long simulation was carried out in India to provide detailed information of spatial and temporal distribution of gas species and particulate matter (PM) and its components in 2015 were predicted using Weather Research Forecasting (WRF) and Community Multiscale Air Quality (CMAQ) models.

83 citations

Journal ArticleDOI
TL;DR: In this article, low cost media based on sugarcane molasses and three different oils, viz. soybean oil, sunflower oil or olive oil, were evaluated for the production of sophorolipids (SLs) from the yeast Candida bombicola in batch shake flasks.

83 citations

Journal ArticleDOI
17 Oct 2019-ACS Nano
TL;DR: Electrophysiological analysis revealed that engineered cardiac tissues matured on CNT-GelMA have increased functionality through integrin-mediated mechanotrasduction (via YAP/TAZ) in contrast to cardiomyocytes cultured on rGO-GELMA.
Abstract: Myocardial microenvironment plays a decisive role in guiding the function and fate of cardiomyocytes, and engineering this extracellular niche holds great promise for cardiac tissue regeneration. Platforms utilizing hybrid hydrogels containing various types of conductive nanoparticles have been a critical tool for constructing engineered cardiac tissues with outstanding mechanical integrity and improved electrophysiological properties. However, there has been no attempt to directly compare the efficacy of these hybrid hydrogels and decipher the mechanisms behind how these platforms differentially regulate cardiomyocyte behavior. Here, we employed gelatin methacryloyl (GelMA) hydrogels containing three different types of carbon-based nanoparticles: carbon nanotubes (CNTs), graphene oxide (GO), and reduced GO (rGO), to investigate the influence of these hybrid scaffolds on the structural organization and functionality of cardiomyocytes. Using immunofluorescent staining for assessing cellular organization and proliferation, we showed that electrically conductive scaffolds (CNT- and rGO-GelMA compared to relatively nonconductive GO-GelMA) played a significant role in promoting desirable morphology of cardiomyocytes and elevated the expression of functional cardiac markers, while maintaining their viability. Electrophysiological analysis revealed that these engineered cardiac tissues showed distinct cardiomyocyte phenotypes and different levels of maturity based on the substrate (CNT-GelMA: ventricular-like, GO-GelMA: atrial-like, and rGO-GelMA: ventricular/atrial mixed phenotypes). Through analysis of gene-expression patterns, we uncovered that the engineered cardiac tissues matured on CNT-GelMA and native cardiac tissues showed comparable expression levels of maturation markers. Furthermore, we demonstrated that engineered cardiac tissues matured on CNT-GelMA have increased functionality through integrin-mediated mechanotransduction (via YAP/TAZ) in contrast to cardiomyocytes cultured on rGO-GelMA.

83 citations

Journal ArticleDOI
TL;DR: In this paper, microfiltration studies of mosambi juice using low-cost ceramic membrane prepared from locally available inorganic precursors were performed by SEM analysis, porosity determination and pure water permeation experiments.

83 citations


Authors

Showing all 7128 results

NameH-indexPapersCitations
Jasvinder A. Singh1762382223370
Dipanwita Dutta1431651103866
Sanjay Gupta9990235039
Santosh Kumar80119629391
Subrata Ghosh7884132147
Rishi Raj7856922423
B. Bhuyan7365821275
Ravi Shankar6667219326
Ashutosh Sharma6657016100
Gautam Biswas6372116146
Sam P. de Visser6225613820
Surendra Nadh Somala6114428273
Manish Kumar61142521762
Mihir Kumar Purkait572679812
Ajaikumar B. Kunnumakkara5720120025
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023118
2022365
20212,032
20201,947
20191,866
20181,647