Indian Institute of Technology Guwahati

About: Indian Institute of Technology Guwahati is a education organization based out in Guwahati, Assam, India. It is known for research contribution in the topics: Catalysis & Computer science. The organization has 6933 authors who have published 17102 publications receiving 257351 citations.

Measurement of γγ *→π0 transition form factor at Belle

Abstract: We report a measurement of the process gamma gamma* -> pi(0) with a 759 fb(-1) data sample recorded with the Belle detector at the KEKB asymmetric-energy e(+)e(-) collider. The pion transition form factor, F(Q(2)), is measured for the kinematical region 4 GeV2 <= Q(2) <= 40 GeV2, where -Q(2) is the invariant-mass squared of a virtual photon. The measured values of Q(2)vertical bar F(Q(2))vertical bar agree well with the previous measurements below Q(2) similar or equal to 9 GeV2 but do not exhibit the rapid growth in the higher Q(2) region seen in another recent measurement, which exceeds the asymptotic QCD expectation by as much as 50%.

Implications of silver nanoparticle induced cell apoptosis for in vitro gene therapy

Abstract: The impact of manufactured nanomaterials on human health and the environment is a major concern for commercial use of nanotechnology based products. A judicious choice of selective usage, lower nanomaterial concentration and use in combination with conventional therapeutic materials may provide the best solution. For example, silver nanoparticles (Ag NPs) are known to be bactericidal and also cytotoxic to mammalian cells. Herein, we investigate the molecular mechanism of Ag NP mediated cytotoxicity in both cancer and non-cancer cells and find that optimum particle concentration leads to programmed cell death in vitro. Also, the benefit of the cytotoxic effects of Ag NPs was tested for therapeutic use in conjunction with conventional gene therapy. The synergistic effect of Ag NPs on the uracil phosphoribosyltransferase expression system sensitized the cells more towards treatment with the drug 5-fluorouracil. Induction of the apoptotic pathway makes Ag NPs a representative of a new chemosensitization strategy for future application in gene therapy.

Prosody modification using instants of significant excitation

Abstract: Prosody modification involves changing the pitch and duration of speech without affecting the message and naturalness. This paper proposes a method for prosody (pitch and duration) modification using the instants of significant excitation of the vocal tract system during the production of speech. The instants of significant excitation correspond to the instants of glottal closure (epochs) in the case of voiced speech, and to some random excitations like onset of burst in the case of nonvoiced speech. Instants of significant excitation are computed from the linear prediction (LP) residual of speech signals by using the property of average group-delay of minimum phase signals. The modification of pitch and duration is achieved by manipulating the LP residual with the help of the knowledge of the instants of significant excitation. The modified residual is used to excite the time-varying filter, whose parameters are derived from the original speech signal. Perceptual quality of the synthesized speech is good and is without any significant distortion. The proposed method is evaluated using waveforms, spectrograms, and listening tests. The performance of the method is compared with linear prediction pitch synchronous overlap and add (LP-PSOLA) method, which is another method for prosody manipulation based on the modification of the LP residual. The original and the synthesized speech signals obtained by the proposed method and by the LP-PSOLA method are available for listening at http://speech.cs.iitm.ernet.in/Main/result/prosody.html.