Indian Institute of Technology Guwahati

About: Indian Institute of Technology Guwahati is a education organization based out in Guwahati, Assam, India. It is known for research contribution in the topics: Adsorption & Catalysis. The organization has 6933 authors who have published 17102 publications receiving 257351 citations.

Magnolol: A Neolignan from the Magnolia Family for the Prevention and Treatment of Cancer

Abstract: The past few decades have witnessed widespread research to challenge carcinogenesis; however, it remains one of the most important health concerns with the worst prognosis and diagnosis. Increasing lines of evidence clearly show that the rate of cancer incidence will increase in future and will create global havoc, designating it as an epidemic. Conventional chemotherapeutics and treatment with synthetic disciplines are often associated with adverse side effects and development of chemoresistance. Thus, discovering novel economic and patient friendly drugs that are safe and efficacious is warranted. Several natural compounds have proved their potential against this dreadful disease so far. Magnolol is a hydroxylated biphenyl isolated from the root and stem bark of Magnolia tree. Magnolol can efficiently prevent or inhibit the growth of various cancers originating from different organs such as brain, breast, cervical, colon, liver, lung, prostate, skin, etc. Considering these perspectives, the current review primarily focuses on the fascinating role of magnolol against various types of cancers, and the source and chemistry of magnolol and the molecular mechanism underlying the targets of magnolol are discussed. This review proposes magnolol as a suitable candidate that can be appropriately designed and established into a potent anti-cancer drug.

Measurement of e+e- →π+π-ψ (2S) via initial state radiation at Belle

Abstract: We report measurement of the cross section of e(+)e(-) -> pi(+)pi(-)psi(2S) between 4.0 and 5.5 GeV, based on an analysis of initial state radiation events in a 980 fb(-1) data sample recorded with the Belle detector. The properties of the Y(4360) and Y(4660) states are determined. Fitting the mass spectrum of pi(+)pi(-)psi(2S) with two coherent Breit-Wigner functions, we find two solutions with identical mass and width but different couplings to electron-positron pairs: M-Y(4360) = (4347 +/- 6 +/- 3) MeV/c(2), Gamma(Y(4360)) = (103 +/- 9 +/- 5) MeV, M-Y(4660) = (4652 +/- 10 +/- 8) MeV/c(2), Gamma(Y(4660)) = (68 +/- 11 +/- 1) MeV; and B[Y(4360) -> pi(+)pi(-)psi(2S)] . Gamma(e+e-)(Y(4360)) = (10.9 +/- 0.6 +/- 0.7) eV and B[Y(4660) -> pi(+)pi(-)psi(2S)] . Gamma(e+e-)(Y(4660)) = (8.1 +/- 1.1 +/- 0.5) eV for one solution; or B[Y(4360) -> pi(+)pi(-)psi(2S)] . Gamma(e+e-)(Y(4360)) = (9.2 +/- 0.6 +/- 0.6) eV and B[Y(4660) -> pi(+)pi(-)psi(2S)] . Gamma(e+e-)(Y(4660)) = (2.0 +/- 0.3 +/- 0.2) eV for the other. Here, the first errors are statistical and the second systematic. Evidence for a charged charmoniumlike structure at 4.05 GeV/c(2) is observed in the pi(+/-)psi(2S) intermediate state in the Y(4360) decays.

Targeting AKT/mTOR in Oral Cancer: Mechanisms and Advances in Clinical Trials.

Abstract: Oral cancer (OC) is a devastating disease that takes the lives of lots of people globally every year. The current spectrum of treatment modalities does not meet the needs of the patients. The disease heterogeneity demands personalized medicine or targeted therapies. Therefore, there is an urgent need to identify potential targets for the treatment of OC. Abundant evidence has suggested that the components of the protein kinase B (AKT)/ mammalian target of rapamycin (mTOR) pathway are intrinsic factors for carcinogenesis. The AKT protein is central to the proliferation and survival of normal and cancer cells, and its downstream protein, mTOR, also plays an indispensable role in the cellular processes. The wide involvement of the AKT/mTOR pathway has been noted in oral squamous cell carcinoma (OSCC). This axis significantly regulates the various hallmarks of cancer, like proliferation, survival, angiogenesis, invasion, metastasis, autophagy, and epithelial-to-mesenchymal transition (EMT). Activated AKT/mTOR signaling is also associated with circadian signaling, chemoresistance and radio-resistance in OC cells. Several miRNAs, circRNAs and lncRNAs also modulate this pathway. The association of this axis with the process of tumorigenesis has culminated in the identification of its specific inhibitors for the prevention and treatment of OC. In this review, we discussed the significance of AKT/mTOR signaling in OC and its potential as a therapeutic target for the management of OC. This article also provided an update on several AKT/mTOR inhibitors that emerged as promising candidates for therapeutic interventions against OC/head and neck cancer (HNC) in clinical studies.