Indian Institute of Technology Guwahati

About: Indian Institute of Technology Guwahati is a education organization based out in Guwahati, Assam, India. It is known for research contribution in the topics: Adsorption & Catalysis. The organization has 6933 authors who have published 17102 publications receiving 257351 citations.

Applications of Cucurbiturils in Medicinal Chemistry and Chemical Biology.

Abstract: The supramolecular chemistry of cucurbit[n]urils (CBn) has been rapidly developing to encompass diverse medicinal applications, including drug formulation and delivery, controlled drug release, and sensing for bioanalytical purposes. This is made possible by their unique recognition properties and very low cytotoxicity. In this review, we summarize the host-guest complexation of biologically important molecules with CBn, and highlight their implementation in medicinal chemistry and chemical biology.

Liquid–liquid equilibrium for ionic liquid systems using COSMO‐RS: Effect of cation and anion dissociation

Abstract: Ionic liquids with their limitless combination of cations and anions can offer an optimal solvent for a specific purpose. But not all corresponding experimental studies are possible as they will be time consuming and expensive. A judicious screening of the various possible solvents is required to select the proper ionic liquid. Conductor-like screening model (COSMO) along with its extension to real solvents can be used for these predictions. In this work, modified version COSMO_LL has been used to predict the liquid–liquid equilibria (LLE) for 32 ternary systems, available in literature, each having an ionic liquid. A complete dissociation of cations and anions of the ionic liquid has been assumed. The root mean square deviation for all these systems is ∼9% which is excellent when compared with ∼50% obtained for predictions using the nondissociated composite molecule. Additionally, experimental LLE data has been collected for four ternary systems, namely: (a) 1-ethyl-3-methylimidazolium ethylsulphate [Emim] [EtSO4] – Ethanol-Hexene, (b) 1-ethyl-3-methylimidazolium ethylsulphate [Emim] [EtSO4] – Ethanol-Heptene, (c) 1,2-dimethyl-3-ethylimidazolium ethylsulphate [E-2,3-dmim] [EtSO4] – Ethanol-Hexene, and (d) 1,2-dimethyl-3-ethylimidazolium ethylsulphate [E-2,3-dmim] [EtSO4] – Ethanol-Heptene. The tie lines have been estimated using NMR and these have been compared with COSMO_LL predictions giving an average rmsd of ∼6%. © 2008 American Institute of Chemical Engineers AIChE J, 2008